LBP, lipopolysaccharide binding protein, 3929

N. diseases: 156; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0243026
Disease: Sepsis
Sepsis
0.380 GeneticVariation disease BEFREE Furthermore, meta-analysis of four studies (including the present study) confirmed that rs2232618 within LBP increased the risk of sepsis (OR = 1.75, <i>P</i> < 0.001 for the dominant model; OR = 6.08, <i>P</i> = 0.003 for the recessive model; OR = 2.72, <i>P</i> < 0.001 for the allelic model). 30479651 2018
CUI: C0243026
Disease: Sepsis
Sepsis
0.380 Biomarker disease BEFREE In these patients, median (interquartile range) LBP (41.8 [41.1] µg/dL vs. 26.2 [25] µg/dL), CRP (240 [205] mg/L vs. 160 [148] mg/dL) and PCT (5.19 [13.68] µg/L vs. 0.39 [1.09] µg/L) were significantly higher than in patients classified as not having sepsis ( P < 0.001 for all three biomarkers). 28135842 2018
CUI: C0243026
Disease: Sepsis
Sepsis
0.380 GeneticVariation disease BEFREE A functional variant of lipopolysaccharide binding protein predisposes to sepsis and organ dysfunction in patients with major trauma. 22167001 2012
CUI: C0243026
Disease: Sepsis
Sepsis
0.380 Biomarker disease CTD_human A functional variant of lipopolysaccharide binding protein predisposes to sepsis and organ dysfunction in patients with major trauma. 22167001 2012
CUI: C0243026
Disease: Sepsis
Sepsis
0.380 Biomarker disease BEFREE The lipopolysaccharide-binding protein is an acute-phase protein that plays a dominant role in the genesis of sepsis by initiating signal transduction pathways leading to the activation of the inflammatory host response. 19707138 2009
CUI: C0243026
Disease: Sepsis
Sepsis
0.380 GeneticVariation disease BEFREE Characterization of a single nucleotide polymorphism in the lipopolysaccharide binding protein and its association with sepsis. 12615620 2003
CUI: C0243026
Disease: Sepsis
Sepsis
0.380 GeneticVariation disease BEFREE The presence of LBP genotypes with the less frequent Gly98 allele was found to be associated with sepsis (p < .02) in male patients, but not in females. 11373419 2001
CUI: C0243026
Disease: Sepsis
Sepsis
0.380 AlteredExpression disease BEFREE Unraveling of the mechanism of transcriptional activation of the LBP gene, involving three known transcription factors, may contribute to our understanding of the acute-phase response and the pathophysiology of sepsis and septic shock. 8668165 1996
CUI: C0243026
Disease: Sepsis
Sepsis
0.380 Biomarker disease BEFREE Thus, lipopolysaccharide-induced activation of monocytes from patients with sepsis may occur through direct binding of lipopolysaccharide to the CD11-CD18 complex or other lipopolysaccharide receptors, whereas binding of the lipopolysaccharide-lipopolysaccharide-binding protein complex to the CD14 receptor may not play a pivotal role in sepsis. 7688151 1993