Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Patients with obesity showed elevated levels of C-reactive protein and lipopolysaccharide-binding protein as compared to non-obese subjects, but no differences were noted for gut permeability between these two groups.
|
30903427 |
2019 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our study suggested that elevated plasma LBP was associated with metabolic syndrome and obesity.
|
30219816 |
2019 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this study we show that mice fed HFD over 8 weeks become obese and show elevated plasma LPS binding protein, yet body weight gain and adiposity is not attenuated in mice lacking Tlr4 or its co-receptor Cd14.
|
30353127 |
2018 |
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Toll-like receptor signaling and serum levels of interferon β and lipopolysaccharide binding protein are related to abdominal obesity: a case-control study between metabolically healthy and metabolically unhealthy obese individuals.
|
29914624 |
2018 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Serum LBP in subjects with obesity was significantly reduced to 26.5±7.1 μg/mL (p-value < 0.001) after one year.
|
30458048 |
2018 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
The trend for increased prevalence of MetS observed with increasing quartiles of LBP seems to be mainly driven by central obesity in our male cohort.
|
30038669 |
2018 |
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In addition, the levels of LBP and FFAs seem to be more related to abdominal obesity than to the presence or absence of metabolic health.
|
28487462 |
2017 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Lipopolysaccharide-binding protein (LBP) has been reported to associate with metabolic diseases, such as obesity, diabetes, and non-alcoholic fatty liver disease.
|
28107471 |
2017 |
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Neuroinflammation in obesity: circulating lipopolysaccharide-binding protein associates with brain structure and cognitive performance.
|
28684860 |
2017 |
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Recent evidence indicates the association of circulating LBP levels with obesity, diabetes, and cardiovascular diseases.
|
28486964 |
2017 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Among metabolic syndrome components, LBP concentrations were independently associated with abdominal obesity (P = 0.002) and low concentrations of HDL-cholesterol (P<0.001).
|
23349936 |
2013 |
Obesity
|
0.600 |
Biomarker
|
disease |
CTD_human |
Serum LBP concentrations increased with age (P<0.001) and were higher in individuals who were overweight or obese than in normal-weight individuals (P<0.001).
|
23349936 |
2013 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
The ob/ob, and high-fat diet-induced obesity mice produced higher amounts of LBP, SAA, and RANTES one day after LPS infusion (1 ng/ml/g body weight) compared with ob/- and normal-fat fed control mice.
|
21239459 |
2012 |
Obesity
|
0.600 |
Therapeutic
|
disease |
RGD |
Dietary supplementation of n-3 PUFA reduces weight gain and improves postprandial lipaemia and the associated inflammatory response in the obese JCR:LA-cp rat.
|
19917068 |
2010 |
Septicemia
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, meta-analysis of four studies (including the present study) confirmed that rs2232618 within LBP increased the risk of sepsis (OR = 1.75, <i>P</i> < 0.001 for the dominant model; OR = 6.08, <i>P</i> = 0.003 for the recessive model; OR = 2.72, <i>P</i> < 0.001 for the allelic model).
|
30479651 |
2018 |
Septicemia
|
0.380 |
Biomarker
|
disease |
BEFREE |
In these patients, median (interquartile range) LBP (41.8 [41.1] µg/dL vs. 26.2 [25] µg/dL), CRP (240 [205] mg/L vs. 160 [148] mg/dL) and PCT (5.19 [13.68] µg/L vs. 0.39 [1.09] µg/L) were significantly higher than in patients classified as not having sepsis ( P < 0.001 for all three biomarkers).
|
28135842 |
2018 |
Sepsis
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, meta-analysis of four studies (including the present study) confirmed that rs2232618 within LBP increased the risk of sepsis (OR = 1.75, <i>P</i> < 0.001 for the dominant model; OR = 6.08, <i>P</i> = 0.003 for the recessive model; OR = 2.72, <i>P</i> < 0.001 for the allelic model).
|
30479651 |
2018 |
Sepsis
|
0.380 |
Biomarker
|
disease |
BEFREE |
In these patients, median (interquartile range) LBP (41.8 [41.1] µg/dL vs. 26.2 [25] µg/dL), CRP (240 [205] mg/L vs. 160 [148] mg/dL) and PCT (5.19 [13.68] µg/L vs. 0.39 [1.09] µg/L) were significantly higher than in patients classified as not having sepsis ( P < 0.001 for all three biomarkers).
|
28135842 |
2018 |
Septicemia
|
0.380 |
Biomarker
|
disease |
CTD_human |
A functional variant of lipopolysaccharide binding protein predisposes to sepsis and organ dysfunction in patients with major trauma.
|
22167001 |
2012 |
Septicemia
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
A functional variant of lipopolysaccharide binding protein predisposes to sepsis and organ dysfunction in patients with major trauma.
|
22167001 |
2012 |
Sepsis
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
A functional variant of lipopolysaccharide binding protein predisposes to sepsis and organ dysfunction in patients with major trauma.
|
22167001 |
2012 |
Sepsis
|
0.380 |
Biomarker
|
disease |
CTD_human |
A functional variant of lipopolysaccharide binding protein predisposes to sepsis and organ dysfunction in patients with major trauma.
|
22167001 |
2012 |
Septicemia
|
0.380 |
Biomarker
|
disease |
BEFREE |
The lipopolysaccharide-binding protein is an acute-phase protein that plays a dominant role in the genesis of sepsis by initiating signal transduction pathways leading to the activation of the inflammatory host response.
|
19707138 |
2009 |
Sepsis
|
0.380 |
Biomarker
|
disease |
BEFREE |
The lipopolysaccharide-binding protein is an acute-phase protein that plays a dominant role in the genesis of sepsis by initiating signal transduction pathways leading to the activation of the inflammatory host response.
|
19707138 |
2009 |
Septicemia
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
Characterization of a single nucleotide polymorphism in the lipopolysaccharide binding protein and its association with sepsis.
|
12615620 |
2003 |