LBP, lipopolysaccharide binding protein, 3929

N. diseases: 156; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity
0.600 AlteredExpression disease BEFREE Patients with obesity showed elevated levels of C-reactive protein and lipopolysaccharide-binding protein as compared to non-obese subjects, but no differences were noted for gut permeability between these two groups. 30903427 2019
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE Our study suggested that elevated plasma LBP was associated with metabolic syndrome and obesity. 30219816 2019
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE In this study we show that mice fed HFD over 8 weeks become obese and show elevated plasma LPS binding protein, yet body weight gain and adiposity is not attenuated in mice lacking Tlr4 or its co-receptor Cd14. 30353127 2018
CUI: C0028754
Disease: Obesity
Obesity
0.600 AlteredExpression disease BEFREE Toll-like receptor signaling and serum levels of interferon β and lipopolysaccharide binding protein are related to abdominal obesity: a case-control study between metabolically healthy and metabolically unhealthy obese individuals. 29914624 2018
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE Serum LBP in subjects with obesity was significantly reduced to 26.5±7.1 μg/mL (p-value < 0.001) after one year. 30458048 2018
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE The trend for increased prevalence of MetS observed with increasing quartiles of LBP seems to be mainly driven by central obesity in our male cohort. 30038669 2018
CUI: C0028754
Disease: Obesity
Obesity
0.600 AlteredExpression disease BEFREE In addition, the levels of LBP and FFAs seem to be more related to abdominal obesity than to the presence or absence of metabolic health. 28487462 2017
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE Lipopolysaccharide-binding protein (LBP) has been reported to associate with metabolic diseases, such as obesity, diabetes, and non-alcoholic fatty liver disease. 28107471 2017
CUI: C0028754
Disease: Obesity
Obesity
0.600 AlteredExpression disease BEFREE Neuroinflammation in obesity: circulating lipopolysaccharide-binding protein associates with brain structure and cognitive performance. 28684860 2017
CUI: C0028754
Disease: Obesity
Obesity
0.600 AlteredExpression disease BEFREE Recent evidence indicates the association of circulating LBP levels with obesity, diabetes, and cardiovascular diseases. 28486964 2017
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE Among metabolic syndrome components, LBP concentrations were independently associated with abdominal obesity (P = 0.002) and low concentrations of HDL-cholesterol (P<0.001). 23349936 2013
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease CTD_human Serum LBP concentrations increased with age (P<0.001) and were higher in individuals who were overweight or obese than in normal-weight individuals (P<0.001). 23349936 2013
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE The ob/ob, and high-fat diet-induced obesity mice produced higher amounts of LBP, SAA, and RANTES one day after LPS infusion (1 ng/ml/g body weight) compared with ob/- and normal-fat fed control mice. 21239459 2012
CUI: C0028754
Disease: Obesity
Obesity
0.600 Therapeutic disease RGD Dietary supplementation of n-3 PUFA reduces weight gain and improves postprandial lipaemia and the associated inflammatory response in the obese JCR:LA-cp rat. 19917068 2010
CUI: C0036690
Disease: Septicemia
Septicemia
0.380 GeneticVariation disease BEFREE Furthermore, meta-analysis of four studies (including the present study) confirmed that rs2232618 within LBP increased the risk of sepsis (OR = 1.75, <i>P</i> < 0.001 for the dominant model; OR = 6.08, <i>P</i> = 0.003 for the recessive model; OR = 2.72, <i>P</i> < 0.001 for the allelic model). 30479651 2018
CUI: C0036690
Disease: Septicemia
Septicemia
0.380 Biomarker disease BEFREE In these patients, median (interquartile range) LBP (41.8 [41.1] µg/dL vs. 26.2 [25] µg/dL), CRP (240 [205] mg/L vs. 160 [148] mg/dL) and PCT (5.19 [13.68] µg/L vs. 0.39 [1.09] µg/L) were significantly higher than in patients classified as not having sepsis ( P < 0.001 for all three biomarkers). 28135842 2018
CUI: C0243026
Disease: Sepsis
Sepsis
0.380 GeneticVariation disease BEFREE Furthermore, meta-analysis of four studies (including the present study) confirmed that rs2232618 within LBP increased the risk of sepsis (OR = 1.75, <i>P</i> < 0.001 for the dominant model; OR = 6.08, <i>P</i> = 0.003 for the recessive model; OR = 2.72, <i>P</i> < 0.001 for the allelic model). 30479651 2018
CUI: C0243026
Disease: Sepsis
Sepsis
0.380 Biomarker disease BEFREE In these patients, median (interquartile range) LBP (41.8 [41.1] µg/dL vs. 26.2 [25] µg/dL), CRP (240 [205] mg/L vs. 160 [148] mg/dL) and PCT (5.19 [13.68] µg/L vs. 0.39 [1.09] µg/L) were significantly higher than in patients classified as not having sepsis ( P < 0.001 for all three biomarkers). 28135842 2018
CUI: C0036690
Disease: Septicemia
Septicemia
0.380 Biomarker disease CTD_human A functional variant of lipopolysaccharide binding protein predisposes to sepsis and organ dysfunction in patients with major trauma. 22167001 2012
CUI: C0036690
Disease: Septicemia
Septicemia
0.380 GeneticVariation disease BEFREE A functional variant of lipopolysaccharide binding protein predisposes to sepsis and organ dysfunction in patients with major trauma. 22167001 2012
CUI: C0243026
Disease: Sepsis
Sepsis
0.380 GeneticVariation disease BEFREE A functional variant of lipopolysaccharide binding protein predisposes to sepsis and organ dysfunction in patients with major trauma. 22167001 2012
CUI: C0243026
Disease: Sepsis
Sepsis
0.380 Biomarker disease CTD_human A functional variant of lipopolysaccharide binding protein predisposes to sepsis and organ dysfunction in patients with major trauma. 22167001 2012
CUI: C0036690
Disease: Septicemia
Septicemia
0.380 Biomarker disease BEFREE The lipopolysaccharide-binding protein is an acute-phase protein that plays a dominant role in the genesis of sepsis by initiating signal transduction pathways leading to the activation of the inflammatory host response. 19707138 2009
CUI: C0243026
Disease: Sepsis
Sepsis
0.380 Biomarker disease BEFREE The lipopolysaccharide-binding protein is an acute-phase protein that plays a dominant role in the genesis of sepsis by initiating signal transduction pathways leading to the activation of the inflammatory host response. 19707138 2009
CUI: C0036690
Disease: Septicemia
Septicemia
0.380 GeneticVariation disease BEFREE Characterization of a single nucleotide polymorphism in the lipopolysaccharide binding protein and its association with sepsis. 12615620 2003