|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
To assess the effects of a new thiazolidine compound-GQ-11-on obesity and insulin resistance induced by a diabetogenic diet in LDL receptor-deficient (LDLr<sup>-/-</sup>) mice.
|
29453462 |
2018 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Extended characterization of the LDL receptor/LCAT double knockout (Ldlr/Lcat-DKO or DKO) mice had led to the discovery of a number of novel protective metabolic phenotypes, including resistance to obesity, nonalcoholic steatohepatitis (NASH) and insulin resistance.
|
29369831 |
2018 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Ten-week-old male LDL receptor-deficient (Ldlr-/-) mice were fed a high-fat, high-sucrose diet (HFHS; 36% lard fat, 36.2% sucrose + 0.15% cholesterol) for 12 wk (baseline), then switched to the HFHS diet alone (obese control), HFHS + 1% c9,t11-CLA (obese fatty acid control), HFHS + 1% t10,c12-CLA (weight-loss-inducing fatty acid), or HFHS + FR (weight-loss control group with 75-85% ad libitum HFHS food intake) for a further 8 wk.
|
29659960 |
2018 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Naringin Activates AMPK Resulting in Altered Expression of SREBPs, PCSK9, and LDLR To Reduce Body Weight in Obese C57BL/6J Mice.
|
30092639 |
2018 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These results implied that the enhanced effect of the combination of berberine with resveratrol on lipid-lowering may be associated with upregulation of low-density-lipoprotein receptor, and could be an effective therapy for hyperlipidemia in some obese-associated disease, such as type II diabetes and metabolic syndrome.
|
30563192 |
2018 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Overall, our results highlight the importance of the LDLR in the growth of triple-negative and HER2-overexpressing breast cancers in the setting of elevated circulating LDL-C, which may be important contributing factors to the increased recurrence and mortality in obese women with breast cancer.
|
28759039 |
2017 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
For the evaluation of biological activity of GQ-177, low-density lipoprotein receptor-deficient (LDLr(-/-)) C57/BL6 mice were fed either a high fat diabetogenic diet (diet-induced obesity), or a high fat atherogenic diet, and treated with vehicle, GQ-177 (20mg/kg/day), pioglitazone (20mg/kg/day, diet-induced obesity model) or rosiglitazone (15mg/kg/day, atherosclerosis model) for 28 days.
|
26706782 |
2016 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
CTD_human |
Stevia-derived compounds attenuate the toxic effects of ectopic lipid accumulation in the liver of obese mice: a transcriptomic and metabolomic study.
|
25554529 |
2015 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Low-density lipoprotein receptor mutant (LDLr(-/-)) mice were fed with customized diabetogenic and/or procalcific diets to induce atherosclerosis, cartilaginous metaplasia and calcification, along with obesity, hyperglycemia, hyperinsulinemia, and hypercholesterolemia at various levels, and euthanized for study after 18-24 weeks on diet.
|
22818582 |
2013 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we demonstrate that adenovirus-mediated overexpression of SIRT1 in the liver of diet-induced insulin-resistant low-density lipoprotein receptor-deficient mice and of genetically obese ob/ob mice attenuates hepatic steatosis and ameliorates systemic insulin resistance.
|
21321189 |
2011 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
To determine whether changes in plasma lipids following a weight loss program were related to modifications in gene expression of the LDL receptor (LDL-R), lipoprotein lipase (LPL), and 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase, overweight/obese premenopausal women were recruited.
|
15795426 |
2005 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms within the LDLR gene are associated with the pathogenesis of familial hypercholesterolemia, atherosclerosis and obesity.
|
12209363 |
2002 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Some are important for obesity only among women (for example beta 2- and beta 3-adrenoceptors, low-density lipoprotein receptor and tumour necrosis factor alpha).
|
10889786 |
2000 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association of the low-density lipoprotein receptor gene with obesity in Native American populations.
|
10914685 |
2000 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
1.The low density lipoprotein receptor is an important regulator of serum cholesterol which may have implications for the development of both hypertension and obesity.
|
8582115 |
1996 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Association of HincII RFLP of low density lipoprotein receptor gene with obesity in essential hypertensives.
|
7634533 |
1995 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
1.Recent molecular genetic studies have implicated the low-density-lipoprotein receptor gene locus (LDLR, at chromosome 19p13.2) in obesity in essential hypertensive patients and in the atherogenic lipoprotein phenotype.
|
7913431 |
1994 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Marked association of a RFLP for the low density lipoprotein receptor gene with obesity in essential hypertensives.
|
1361731 |
1992 |