LDLR, low density lipoprotein receptor, 3949

N. diseases: 336; N. variants: 1434
Disease: Steatohepatitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.430 AlteredExpression disease BEFREE We also report the finding that steatosis abrogates hepatic LDLR expression and increases circulating LDL levels in a PCSK9-dependent manner. 31004037 2019
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.430 Biomarker disease CTD_human Stevia-derived compounds attenuate the toxic effects of ectopic lipid accumulation in the liver of obese mice: a transcriptomic and metabolomic study. 25554529 2015
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.430 Biomarker disease BEFREE Dietary cholesterol exacerbates hepatic steatosis and inflammation in obese LDL receptor-deficient mice. 21690266 2011
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.430 Biomarker disease BEFREE Here, we demonstrate that adenovirus-mediated overexpression of SIRT1 in the liver of diet-induced insulin-resistant low-density lipoprotein receptor-deficient mice and of genetically obese ob/ob mice attenuates hepatic steatosis and ameliorates systemic insulin resistance. 21321189 2011
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.430 Biomarker disease HPO