LEP, leptin, 3952

N. diseases: 931; N. variants: 15
Disease: Hypogonadism ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020619
Disease: Hypogonadism
Hypogonadism 		0.650 Biomarker disease BEFREE The observed link between hyperleptinemia and hypogonadism is in line with previous evidence on direct effects of leptin on testosterone production. 28366446 2017
CUI: C0020619
Disease: Hypogonadism
Hypogonadism 		0.650 AlteredExpression disease BEFREE Mice fed IED showed severe hypogonadism with a significant reduction of serum levels of testosterone (-83%) and of luteinizing hormone (-86%), as well as reduced body weight gain, body fat and plasma leptin. 28648620 2017
CUI: C0020619
Disease: Hypogonadism
Hypogonadism 		0.650 Therapeutic disease RGD 7α-methyl-19-nortestosterone vs. testosterone implants for hypogonadal osteoporosis: a preclinical study in the aged male orchidectomized rat model. 21790658 2011
CUI: C0020619
Disease: Hypogonadism
Hypogonadism 		0.650 GeneticVariation disease BEFREE A new missense mutation in the leptin gene causes mild obesity and hypogonadism without affecting T cell responsiveness. 20382689 2010
CUI: C0020619
Disease: Hypogonadism
Hypogonadism 		0.650 Biomarker disease BEFREE Leptin replacement rescues the phenotype of morbid obesity and hypogonadism in leptin-deficient adults. 18854428 2008
CUI: C0020619
Disease: Hypogonadism
Hypogonadism 		0.650 Therapeutic disease CTD_human Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults. 15070752 2004
CUI: C0020619
Disease: Hypogonadism
Hypogonadism 		0.650 Biomarker disease CTD_human Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults. 15070752 2004
CUI: C0020619
Disease: Hypogonadism
Hypogonadism 		0.650 GeneticVariation disease BEFREE We have previously demonstrated that genetically based leptin deficiency due to a missense leptin gene mutation in a highly consanguineous extended Turkish pedigree is associated with morbid obesity and hypogonadism. 10523015 1999
CUI: C0020619
Disease: Hypogonadism
Hypogonadism 		0.650 Biomarker disease CTD_human A leptin missense mutation associated with hypogonadism and morbid obesity. 9500540 1998
CUI: C0020619
Disease: Hypogonadism
Hypogonadism 		0.650 Therapeutic disease CTD_human A leptin missense mutation associated with hypogonadism and morbid obesity. 9500540 1998
CUI: C0020619
Disease: Hypogonadism
Hypogonadism 		0.650 Biomarker disease HPO