LEP, leptin, 3952

N. diseases: 931; N. variants: 15
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0021368
Disease: Inflammation
Inflammation
0.370 Therapeutic phenotype CTD_human In vivo cytochrome P450 activity alterations in diabetic nonalcoholic steatohepatitis mice. 27712037 2017
CUI: C0021368
Disease: Inflammation
Inflammation
0.370 Biomarker phenotype CTD_human In vivo cytochrome P450 activity alterations in diabetic nonalcoholic steatohepatitis mice. 27712037 2017
CUI: C0021368
Disease: Inflammation
Inflammation
0.370 AlteredExpression phenotype LHGDN Potential role of adipocytokine leptin in acute coronary syndrome. 18381870 2008
CUI: C0021368
Disease: Inflammation
Inflammation
0.370 Biomarker phenotype LHGDN Leptin and adiponectin stimulate the release of proinflammatory cytokines and prostaglandins from human placenta and maternal adipose tissue via nuclear factor-kappaB, peroxisomal proliferator-activated receptor-gamma and extracellularly regulated kinase 1/2. 15905315 2005
CUI: C0021368
Disease: Inflammation
Inflammation
0.370 Biomarker phenotype LHGDN Low-grade systemic inflammation, hypoadiponectinemia and a high concentration of leptin are present in very young obese children, and correlate with metabolic syndrome. 15803114 2005
CUI: C0021368
Disease: Inflammation
Inflammation
0.370 Biomarker phenotype LHGDN Significant correlation between leptin and TNFalpha (similarly demonstrated by other authors in models of bacterial inflammation) indicates that TNFalpha can be the crucial regulator of leptin generation in the early postoperative period. 15588161 2005
CUI: C0021368
Disease: Inflammation
Inflammation
0.370 Biomarker phenotype LHGDN Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells. 15232612 2004
CUI: C0021368
Disease: Inflammation
Inflammation
0.370 Biomarker phenotype LHGDN Leptin and prolactin modulate the expression of SOCS-1 in association with interleukin-6 and tumor necrosis factor-alpha in mammary cells: a role in differentiated secretory epithelium. 15256287 2004
CUI: C0021368
Disease: Inflammation
Inflammation
0.370 Therapeutic phenotype CTD_human Anti-inflammatory effects of leptin and cholecystokinin on acetic acid-induced colitis in rats: role of capsaicin-sensitive vagal afferent fibers. 14599722 2003
CUI: C0021368
Disease: Inflammation
Inflammation
0.370 Biomarker phenotype LHGDN Systemic inflammation, adipose tissue tumor necrosis factor, and leptin expression. 12690081 2003
CUI: C0021368
Disease: Inflammation
Inflammation
0.370 Biomarker phenotype CTD_human Anti-inflammatory effects of leptin and cholecystokinin on acetic acid-induced colitis in rats: role of capsaicin-sensitive vagal afferent fibers. 14599722 2003