|
Obesity, Morbid
|
0.400 |
Biomarker
|
disease |
BEFREE |
SH2B1 is well-known as an adaptor protein, and deletion of SH2B1 results in severe obesity and both leptin and insulin resistance.
|
31739166 |
2020 |
|
Obesity, Morbid
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Congenital Leptin Deficiency and Leptin Gene Missense Mutation Found in Two Colombian Sisters with Severe Obesity.
|
31067764 |
2019 |
|
Obesity, Morbid
|
0.400 |
Biomarker
|
disease |
BEFREE |
Circulating miRNAs showed significant association with plasma levels of adipokines; adiponectin, leptin, and L/A ratios in adolescents with severe obesity.
|
30309709 |
2019 |
|
Obesity, Morbid
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Leptin levels were higher in patients with severe obesity (p < 0.001).
|
31210052 |
2019 |
|
Obesity, Morbid
|
0.400 |
Biomarker
|
disease |
BEFREE |
University hospital, United States METHODS: Spexin, body mass index (BMI), insulin, glucose, total and high molecular weight adiponectin, leptin, and high sensitivity C- reactive protein were measured longitudinally (baseline, 6 mo, and 12 mo) after RYGB surgery in girls with severe obesity (n = 12; age = 16.7 ± 1.5 years; BMI = 51.6 ± 2.9 kg/m<sup>2</sup>).
|
30131311 |
2018 |
|
Obesity, Morbid
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Early-onset severe obesity due to complete deletion of the leptin gene in a boy.
|
29040067 |
2017 |
|
Obesity, Morbid
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Leptin receptors belong to glycoprotein 130 (gp130) family of cytokine receptors and exist in six isoforms (LEPR a-f), and all the isoforms are encoded by LEPR gene; out of these isoforms, the LEPR-b receptor is the 'longest form,' and in most of the cases, mutations in this isoform cause severe obesity.
|
27313173 |
2016 |
|
Obesity, Morbid
|
0.400 |
Biomarker
|
disease |
BEFREE |
Leptin therapy reverses morbid obesity related to congenital leptin deficiency and appears to possibly treat lipodystrophy, a finding which has led to the approval of leptin for the treatment of lipodystrophy in the USA and Japan.
|
26313897 |
2015 |
|
Obesity, Morbid
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Among 73 children with severe obesity (BMI SDS > 3.0), we identified 22 probands and 5 relatives, carrying 10 different loss-of-function homozygous mutations in LEP, leptin receptor (LEPR), and MC4R genes, including 4 novel variants.
|
26179253 |
2015 |
|
Obesity, Morbid
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this issue, we have gathered together a group of essays by some of the world leaders in leptin research, including an overview by Dr Jeffrey Friedman who, in his seminal article in December 1994, described the adipocyte-derived hormone, the lack of which was responsible for the severe obesity in ob/ob mice and suggested that it should be named leptin.
|
25143632 |
2014 |
|
Obesity, Morbid
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We speculated that the mutation H118L in LEP might be associated with severe obesity in Chinese subjects.
|
24707501 |
2014 |
|
Obesity, Morbid
|
0.400 |
Biomarker
|
disease |
BEFREE |
The discovery of the adipocyte hormone leptin and the demonstration that severe obesity in ob/ob and db/db mice results from mutation of genes encoding leptin and its receptor, respectively, ushered in a new era of obesity research.
|
23722910 |
2013 |
|
Obesity, Morbid
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Congenital leptin deficiency, caused by a very rare mutation in the gene encoding leptin, leads to severe obesity, hyperphagia and impaired satiety.
|
23799059 |
2013 |
|
Obesity, Morbid
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We have assessed the incidence of LEP and MC4R mutations and associated hormonal profiles, in a cohort of randomly selected Pakistani children with early onset of severe obesity.
|
22463805 |
2012 |
|
Obesity, Morbid
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Homozygous Leptin(145E/145E) mutant mice exhibited morbid obesity, accompanied by adipose hypertrophy, energy imbalance, and liver steatosis.
|
21151569 |
2010 |
|
Obesity, Morbid
|
0.400 |
Biomarker
|
disease |
BEFREE |
At the time of follow-up, AMS children exhibited 3-fold lower prevalence of severe obesity (11 vs. 35%, P = 0.004), greater insulin sensitivity (homeostasis model assessment of insulin resistance index 3.4 +/- 0.3 vs. 4.8 +/- 0.5, P = 0.02), improved lipid profile (cholesterol/high-density lipoprotein cholesterol 2.96 +/- 0.11 vs 3.40 +/- 0.18, P = 0.03; high-density lipoprotein cholesterol 1.50 +/- 0.05 vs. 1.35 +/- 0.05 mmol/liter, P = 0.04), lower C-reactive protein (0.88 +/- 0.17 vs. 2.00 +/- 0.34 microg/ml, P = 0.004), and leptin (11.5 +/- 1.5 vs.19.7 +/- 2.5 ng/ml, P = 0.005) and increased ghrelin (1.28 +/- 0.06 vs.1.03 +/- 0.06 ng/ml, P = 0.005) than BMS offspring (AMS vs. BMS, respectively, for all).
|
19820018 |
2009 |
|
Obesity, Morbid
|
0.400 |
Biomarker
|
disease |
BEFREE |
Leptin replacement rescues the phenotype of morbid obesity and hypogonadism in leptin-deficient adults.
|
18854428 |
2008 |
|
Obesity, Morbid
|
0.400 |
Biomarker
|
disease |
BEFREE |
Leptin is an adipocyte-secreted hormone, and deficiency of either leptin or its receptor has been shown to cause morbid obesity in animals and in humans.
|
17728393 |
2007 |
|
Obesity, Morbid
|
0.400 |
Biomarker
|
disease |
BEFREE |
We and others have identified several single gene defects that disrupt the molecules in the leptin-melanocortin pathway causing severe obesity in humans.
|
17122358 |
2006 |
|
Obesity, Morbid
|
0.400 |
Biomarker
|
disease |
BEFREE |
To investigate the physiological role of leptin in the control of meal size and the response to satiety signals, and to identify brain areas mediating this effect, we studied Koletsky (fa(k)/fa(k)) rats, which develop severe obesity due to the genetic absence of leptin receptors.
|
15711637 |
2005 |
|
Obesity, Morbid
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Rare mutations in the leptin (LEP) gene cause severe obesity.
|
15937081 |
2005 |
|
Obesity, Morbid
|
0.400 |
Biomarker
|
disease |
CTD_human |
Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults.
|
15070752 |
2004 |
|
Obesity, Morbid
|
0.400 |
Biomarker
|
disease |
BEFREE |
We document here that leptin replacement therapy in leptin-deficient adults with established morbid obesity results in profound weight loss, increased physical activity, changes in endocrine function and metabolism, including resolution of type 2 diabetes mellitus and hypogonadism, and beneficial effects on ingestive and noningestive behavior.
|
15070752 |
2004 |
|
Obesity, Morbid
|
0.400 |
Therapeutic
|
disease |
CTD_human |
Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults.
|
15070752 |
2004 |
|
Obesity, Morbid
|
0.400 |
Biomarker
|
disease |
BEFREE |
The only situation in which obesity does not parallel leptin values is the rare case of morbid obesity due to leptin deficiency caused by missense mutation of the leptin gene.
|
12519870 |
2003 |