|
Polycystic Ovary Syndrome
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A PCOS diagnosis made the largest contribution to predicting serum levels of leptin, adiponectin, resistin, and ghrelin in all stepwise multiple regression models, which included PCOS diagnosis, BMI, WHR, luteinizing hormone, total testosterone, free testosterone and homeostatic model assessment of insulin resistance as independent predictors.
|
30623695 |
2019 |
|
Polycystic Ovary Syndrome
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We investigated the association between LEP variants and plasma leptin levels with PCOS in Tunisian and Bahraini Arab women.
|
30721746 |
2019 |
|
Polycystic Ovary Syndrome
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The effects of high intensity-interval training on vaspin, adiponectin and leptin levels in women with polycystic ovary syndrome.
|
31516017 |
2019 |
|
Polycystic Ovary Syndrome
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
No significant association in the leptin gene polymorphic locus rs1137101 with PCOS was seen in the results of the present study.
|
30635060 |
2019 |
|
Polycystic Ovary Syndrome
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Abnormalities in leptin-adiponectin (adipocyte biology), oxidative stress and autoimmunity are among the mechanisms studied regarding pathogenesis of PCOS.
|
31823915 |
2019 |
|
Polycystic Ovary Syndrome
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Moreover, Lira improved dyslipidemia and elevated leptin levels in PCOS.
|
31593246 |
2019 |
|
Polycystic Ovary Syndrome
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
However, ghrelin levels were significantly lower; and leptin levels were significantly higher in obese PCOS patients in comparison with lean patients (P = 0.0001 for both).
|
30131073 |
2018 |
|
Polycystic Ovary Syndrome
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, deregulation of leptin levels has been correlated with the pathogenesis of various disorders associated with reproduction and gestation, including polycystic ovary syndrome, recurrent miscarriage, gestational diabetes mellitus, pre-eclampsia and intrauterine growth restriction.
|
29160594 |
2018 |
|
Polycystic Ovary Syndrome
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The leptin levels were similar between the women with PCOS and controls and did not statistically significantly correlate with HMW adiponectin or sympathetic activity.
|
29428305 |
2018 |
|
Polycystic Ovary Syndrome
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
IGF-1R and Leptin Expression Profile and the Effects of Metformin Treatment on Metabolic and Endocrine Parameters in PCOS Mice.
|
29430464 |
2017 |
|
Polycystic Ovary Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Statistically significant positive interactive effects were found between PCOS status obesity status and leptin (effect size = 0.321, interaction P = 0.036), indicating that the overweight/obese women with PCOS had the higher levels of leptin compared with the control group.
|
28332170 |
2017 |
|
Polycystic Ovary Syndrome
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The pooling analysis of all relevant studies revealed that leptin levels were significantly higher in patients with PCOS than in controls, with standardized mean difference of 1.62 (95% confidence interval: 1.01-2.23).
|
27798245 |
2017 |
|
Polycystic Ovary Syndrome
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
To investigate the association of LEPR polymorphisms and plasma leptin and soluble leptin receptor (sOB-R) levels with polycystic ovary syndrome (PCOS) in Chinese women.
|
29749830 |
2017 |
|
Polycystic Ovary Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Similarly, in male offspring the leptin concentrations appeared associated with PCOS after correction for confounders (relative change 1.55 [1.12; 2.14]).
|
28228318 |
2017 |
|
Polycystic Ovary Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Obesity plays an important role through the insulin, leptin and endocannabinoid system in the pathological process of PCOS, leading to more severe clinical manifestations.
|
23769971 |
2013 |
|
Polycystic Ovary Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
The gene expression levels of CD11c along with TNF α and leptin in SAT remained significantly higher in PCOS women than in normal women (P<0.05).
|
22945299 |
2012 |
|
Polycystic Ovary Syndrome
|
0.400 |
Biomarker
|
disease |
CTD_human |
The expression of sex steroid synthesis and inactivation enzymes in subcutaneous adipose tissue of PCOS patients.
|
22381227 |
2012 |
|
Polycystic Ovary Syndrome
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The leptin levels in the PCOS women carrying Pro12Ala genotype were higher than in those with Pro12Pro and Ala12Ala.
|
21827375 |
2012 |
|
Polycystic Ovary Syndrome
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These data suggested that sex steroid converting enzymes expression was different in SAT of PCOS patients that might contribute to abnormal testosterone and leptin level of PCOS patients.
|
22381227 |
2012 |
|
Polycystic Ovary Syndrome
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We found no independent effect of PCOS on the adipose expression of leptin, adiponectin, or IL-6 or on the plasma levels of adiponectin, leptin, resistin, visfatin, and TNF-α.
|
22607892 |
2012 |
|
Polycystic Ovary Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Serum leptin was higher in overweight/obese patients with PCOS than in all normal-weight control women.
|
21419406 |
2011 |
|
Polycystic Ovary Syndrome
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The results overall suggest that androgen and leptin levels are increased in PCOS and obesity.
|
20500101 |
2010 |
|
Polycystic Ovary Syndrome
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Subcutaneous and omental fat expression of adiponectin and leptin in women with polycystic ovary syndrome.
|
17562334 |
2008 |
|
Polycystic Ovary Syndrome
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
There were significant negative correlations between visceral and SC fat mass by both ultrasound as well as adiponectin and leptin expression in women with PCOS.
|
17562334 |
2008 |
|
Polycystic Ovary Syndrome
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
There were no significant differences in expression of leptin mRNA and short and long Ob-Rs between PCOS and control (P > 0.05).
|
17895321 |
2007 |