|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Blocking FAO and/or leptin re-sensitizes them to chemotherapy and inhibits BCSCs in mouse breast tumors in vivo.
|
29249690 |
2018 |
|
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Accordingly, HNK treatment inhibited breast tumor growth in diet-induced-obese mouse model (exhibiting high leptin levels) in a manner associated with activation of miR-34a and inhibition of MTA1-β-catenin.
|
26036628 |
2015 |
|
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Leptin, an adipokine is produced in high levels in obese individuals, and its receptor is overexpressed in breast tumors and lymph node metastases.
|
22200873 |
2012 |
|
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Perturbations in the adipocytokine profile, especially higher levels of leptin, are a major cause of breast tumor progression and metastasis; the underlying mechanisms, however, are not well understood.
|
22270359 |
2012 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Importantly, leptin increased breast tumor growth in nude mice.
|
21555376 |
2011 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Efficacy of a leptin receptor antagonist peptide in a mouse model of triple-negative breast cancer.
|
21353530 |
2011 |
|
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Leptin can up-regulate the expression of ERalpha and down-regulate the expression of the ERbeta in human breast tumor.
|
20193256 |
2010 |
|
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Leptin is overexpressed in human breast tumors and is produced by breast cancer cells in response to obesity-related stimuli.
|
19408304 |
2009 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
There is evidence that adipokines such as leptin and adiponectin may influence breast tumor development.
|
19723917 |
2009 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Evidence indicates that leptin plays an important role in mammary tumor formation; however, the mechanisms involved are poorly understood.
|
18715880 |
2008 |
|
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Mechanism of leptin expression in breast cancer cells: role of hypoxia-inducible factor-1alpha.
|
17653093 |
2008 |
|
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3.
|
17344214 |
2007 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Together, these results provide further evidence suggesting leptin is a MT growth-promoting factor.
|
16825198 |
2006 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
The association between both intratumoral Lep-R(L) and Lep-R(S) mRNA high tumors and a poor prognosis in the presence of high serum leptin or high intratumoral leptin mRNA levels seems to suggest that the leptin and Lep-R(L)/Lep-R(S) pathways are implicated in the growth stimulation of breast tumors.
|
16206269 |
2006 |
|
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Messenger RNA expression of leptin and leptin receptors and their prognostic value in 322 human primary breast cancers.
|
16609020 |
2006 |
|
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Increased expression of leptin and the leptin receptor as a marker of breast cancer progression: possible role of obesity-related stimuli.
|
16533767 |
2006 |
|
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Leptin: a proliferative factor for breast cancer? Study on human ductal carcinoma.
|
16009333 |
2005 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer.
|
15240518 |
2004 |
|
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Serum leptin, prolactin and vascular endothelial growth factor (VEGF) levels in patients with breast cancer.
|
12687277 |
2003 |
|
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Leptin enhances, via AP-1, expression of aromatase in the MCF-7 cell line.
|
12734209 |
2003 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Leptin mediates a proliferative response in human MCF7 breast cancer cells.
|
12054648 |
2002 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Leptin protein was identified in T47D breast cancer cells by indirect immunofluorescent staining and in samples of the same breast tumors used for Northern studies by enzyme-linked immunosorbent assays (ELISA).
|
10364481 |
1999 |