LEPR, leptin receptor, 3953

N. diseases: 416; N. variants: 57
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis
0.360 Biomarker disease BEFREE Therefore, we hypothesized that glucagon increases hepatic LEPR, which is necessary for glucagon-mediated reversal of hepatic steatosis. 31673703 2020
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis
0.360 Biomarker disease BEFREE In the multiple regression analysis leptin, sObR, FLpI, waist-to-hip ratio, HbA1c, lipids, and HOMA-IR correlated independently with HS (P < 0.0001 for all). 30052309 2018
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis
0.360 Biomarker disease CTD_human Increased susceptibility to troglitazone-induced mitochondrial permeability transition in type 2 diabetes mellitus model rat. 29743445 2018
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis
0.360 Biomarker disease BEFREE MiR-30c-5p ameliorates hepatic steatosis in leptin receptor-deficient (db/db) mice via down-regulating FASN. 28088781 2017
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis
0.360 Biomarker disease CTD_human Arsenic induces diabetic effects through beta-cell dysfunction and increased gluconeogenesis in mice. 25367288 2014
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis
0.360 GeneticVariation disease BEFREE The LEPR rs1137100 is also associated with simple steatosis (OR 2.27, 95% CI 1.27-4.08, P = 0.006). 23278404 2013
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis
0.360 Biomarker disease BEFREE The interaction of HOMA2-IR and IL10 was consistent in both races whereas for LEPR and TGF-beta1 the interactions were statistically significant in only one of the racial groups.These results could imply that some IL10,LEPR and TGF-beta1 polymorphisms may modify an association between steatosis and IR. 19401628 2009
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis
0.360 Biomarker disease BEFREE There was a trend toward lower levels of mRNA encoding the long form of the leptin receptor in hepatic tissue from patients with NASH compared to those with steatosis only. 17294310 2007