LIPA, lipase A, lysosomal acid type, 3988

N. diseases: 130; N. variants: 50
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.160 Biomarker disease BEFREE Future studies will continue to focus on the role of LAL in the crosstalk between lipid metabolism and cellular function in health and diseases including coronary heart disease. 30866656 2019
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.160 GeneticVariation disease BEFREE Our findings show that common LIPA exonic variants in the signal peptide are of minimal functional significance and suggest coronary artery disease risk is instead associated with increased LIPA function linked to intronic variants. 31645127 2019
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.160 Biomarker disease BEFREE Future studies will continue to focus on the key pathophysiological functions of LAL in health and diseases including CHD. 29547398 2018
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.160 GeneticVariation disease BEFREE Genotype rs2246942-GG of the LIPA gene was associated with an increased risk of CHD [CHD cases versus healthy controls: P=0.04; odds ratio (OR)=1.63; 95% confidence interval (CI)=1.02-2.60). 23653095 2013
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.160 GeneticVariation disease GWASCAT A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease. 21606135 2011
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.160 GeneticVariation disease GWASDB A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. 21378988 2011
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.160 GeneticVariation disease GWASDB A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease. 21606135 2011
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.160 Biomarker disease BEFREE A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease. 21606135 2011
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.160 GeneticVariation disease GWASDB Large-scale gene-centric analysis identifies novel variants for coronary artery disease. 21966275 2011
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.160 GeneticVariation disease GWASCAT A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. 21378988 2011
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.160 AlteredExpression disease BEFREE The association of reduced LAL activity with the premature development of coronary artery disease has been demonstrated in patients with hypercholesterolemia, and in the present study we show for the first time that LAL expression is suppressed in monocytes from patients with Lp(a) hyperlipidemia and by purified Lp(a). 12972290 2003