|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
|
27790247 |
2016 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
|
21347282 |
2011 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Moreover, of the 8 sex-biased genes at these loci, 4 have been directly linked to monogenic disorders of lipid metabolism and show an expression profile in females (elevated expression of ABCA1, APOA5 and LDLR; reduced expression of LIPC) that is consistent with the lower female risk of coronary artery disease.
|
21858147 |
2011 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This suggests that the LIPC -514C>T variant significantly affects training-induced anti-atherogenic changes in VLDL-TG, VLDL particles, and HDL through an association with increased LPL activity in CC subjects, which could guide therapeutic strategies to reduce CHD risk.
|
21960661 |
2011 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our result suggest that the G-250A, C-514T polymorphisms of LIPC gene are not associated with CHD susceptibility.
|
20851298 |
2010 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The common C-480T polymorphism (rs1800588) of the hepatic lipase gene (LIPC) has been associated with high-density lipoprotein (HDL) cholesterol, atherosclerosis, and coronary artery disease.
|
19558527 |
2009 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
High HDL cholesterol does not protect against coronary artery disease when associated with combined cholesteryl ester transfer protein and hepatic lipase gene variants.
|
18164013 |
2008 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation in the hepatic lipase gene and the risk of coronary heart disease among US diabetic men: potential interaction with obesity.
|
16570154 |
2006 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We studied whether the hepatic lipase gene -250G(guanine)-->A(adenine) polymorphism affect blood lipids level and the coronary heart disease.
|
16153627 |
2006 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The multivariate model included 512 men with coronary artery disease from the REGRESS study who were completely genotyped for eight polymorphisms selected in the univariate procedure (ie, APOA1 G(-75)A, ABCA1 C(-477)T, ABCA1 G1051A, APOC3 T3206G, APOE Arg158Cys, LIPC C(-514)T, LPL Asn291Ser and LPL Ser447Stop).
|
15657615 |
2005 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association between -250G/A polymorphism of the hepatic lipase gene promoter and coronary artery disease and HDL-C levels in a Southern Brazilian population.
|
15099346 |
2004 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Thus, in this prospective cohort study, the LIPC-480 TT genotype increased susceptibility to CHD only in those subjects with normal levels of physical activity, not in those with the high-risk genotype who were vigorously active.
|
14585761 |
2003 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the LIPC-480C>T polymorphism was associated with subclinical CHD in type 1 diabetes.
|
11916946 |
2002 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genetic variations of the hepatic lipase gene in Korean patients with coronary artery disease.
|
10936588 |
2000 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The entire coding and boundary regions of LPL and HTGL genes were analyzed by direct sequencing in 20 patients with both LHDL/HTG and diagnosed CHD.
|
10729390 |
2000 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Hepatic lipase (LIPC) promoter polymorphism in men with coronary artery disease. Allele frequency and effects on hepatic lipase activity and plasma HDL-C concentrations.
|
10446080 |
1999 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Common C-to-T substitution at position -480 of the hepatic lipase promoter associated with a lowered lipase activity in coronary artery disease patients.
|
9409263 |
1997 |