Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0019243
Disease: Angioedemas, Hereditary
Angioedemas, Hereditary
0.090 GeneticVariation disease BEFREE Directed evolution of the first Kunitz domain of TFPI1 had already yielded the potent kallikrein inhibitor, Kalbitor® (ecallantide), which is an FDA-approved drug to treat acute attacks of hereditary angioedema. 30952698 2019
CUI: C0019243
Disease: Angioedemas, Hereditary
Angioedemas, Hereditary
0.090 Biomarker disease BEFREE A review of kallikrein inhibitor lanadelumab in hereditary angioedema. 31234673 2019
CUI: C0019243
Disease: Angioedemas, Hereditary
Angioedemas, Hereditary
0.090 Biomarker disease BEFREE Oral plasma kallikrein inhibitor BCX7353 for treatment of hereditary angioedema. 31635497 2019
CUI: C0019243
Disease: Angioedemas, Hereditary
Angioedemas, Hereditary
0.090 Biomarker disease BEFREE Oral Plasma Kallikrein Inhibitor for Prophylaxis in Hereditary Angioedema. 30044938 2018
CUI: C0019243
Disease: Angioedemas, Hereditary
Angioedemas, Hereditary
0.090 Biomarker disease BEFREE Lanadelumab (DX-2930) is a new kallikrein inhibitor with the potential for prophylactic treatment of hereditary angioedema with C1 inhibitor deficiency. 28225674 2017
CUI: C0019243
Disease: Angioedemas, Hereditary
Angioedemas, Hereditary
0.090 AlteredExpression disease BEFREE In the past, few treatment options were available; however, several new therapies with proven efficacy have recently become available to treat and prevent HAE attacks, such as plasma-derived and recombinant C1-INHs that replace the deficient protein, bradykinin receptor antagonist (icatibant) that blocks bradykinin activity and kallikrein inhibitor (ecallantide) that prevents bradykinin release. 23634741 2013
CUI: C0019243
Disease: Angioedemas, Hereditary
Angioedemas, Hereditary
0.090 Biomarker disease BEFREE Ecallantide is a potent and specific plasma kallikrein inhibitor approved for the treatment of acute attacks of HAE affecting any anatomic site. 22149337 2012
CUI: C0019243
Disease: Angioedemas, Hereditary
Angioedemas, Hereditary
0.090 Biomarker disease BEFREE Critical role of kallikrein in hereditary angioedema pathogenesis: a clinical trial of ecallantide, a novel kallikrein inhibitor. 17559913 2007
CUI: C0019243
Disease: Angioedemas, Hereditary
Angioedemas, Hereditary
0.090 Biomarker disease BEFREE The therapeutic potential of a kallikrein inhibitor for treating hereditary angioedema. 16916274 2006