Septicemia
|
0.390 |
Biomarker
|
disease |
BEFREE |
The association of theses SNPs with the following parameters was evaluated: (1) the presence of sepsis; (2) severity and clinical outcomes; (3) APACHE II and SOFA scores; and (4) procalcitonin, C-reactive protein, tumor necrosis factor, lymphotoxin alpha, interleukin 1 beta and interleukin 10 plasma concentrations.
|
27592234 |
2016 |
Septicemia
|
0.390 |
Biomarker
|
disease |
BEFREE |
Genotypes of TNF-β and the production of TNF-α were related to the occurrence of sepsis.
|
24796628 |
2014 |
Septicemia
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to evaluate the influence of SNPs LTA +252A>G, TNF-863C>A and TNF-308G>A on susceptibility to sepsis, acute respiratory distress syndrome (ARDS), septic shock and sepsis mortality.
|
22507624 |
2012 |
Septicemia
|
0.390 |
Biomarker
|
disease |
CTD_human |
Association of tumor necrosis factor β genetic polymorphism and sepsis susceptibility.
|
22977509 |
2011 |
Septicemia
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Association between lymphotoxin-α intron +252 polymorphism and sepsis: a meta-analysis.
|
21366408 |
2011 |
Septicemia
|
0.390 |
Biomarker
|
disease |
BEFREE |
Thus, we investigated the possible association between 12 polymorphisms located in the interleukin-6 (IL6), IL10, TLR-2, Toll-like receptor-4 (TLR-4), tumor necrosis factor-α and tumor necrosis factor-β (lymphotoxin α--LTA) genes and sepsis.
|
20835611 |
2010 |
Septicemia
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
To evaluate the importance of the LT-alpha (+250 G/A) polymorphism for the clinical outcome of patients developing postsurgical sepsis, 85 patients were consecutively included into this study.
|
15187748 |
2004 |
Septicemia
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
These data indicate an association between TNFbeta polymorphism and postoperative complications and they suggest the B2/B2 genotype as a high risk factor for the development of sepsis after elective operative trauma.
|
12558135 |
2003 |
Septicemia
|
0.390 |
Biomarker
|
disease |
BEFREE |
We adapted template-directed dye-terminator incorporation with fluorescence polarization detection (TDI-FP) to the analysis of eight SNPs implicated in mediating the sepsis syndrome: TNF-alpha (-308), TNF-alpha (-238), TNF-beta (+250), IL-1beta (+3953), IL-6 (-174), IL-10 (-592), plasminogen activator inhibitor-1 (PAI-1 (-675)), and TLR4 299 (+1032).
|
12411588 |
2002 |
Septicemia
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
In contrast to the TNF-beta NcoI polymorphism, which has been associated with patients' nonsurvival, the allele IL-1raA2 of the polymorphism within the intron 2 of IL-1ra may contribute to susceptibility to sepsis.
|
10446828 |
1999 |