LTA, lymphotoxin alpha, 4049

N. diseases: 353; N. variants: 26
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis
0.360 GeneticVariation disease BEFREE The objective of this study was to investigate whether genetic variation in TNF, LTA, TNFRSF1A and TNFRSF1B was associated with susceptibility to or death from severe sepsis in Chinese Han population. 23029405 2012
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis
0.360 Biomarker disease CTD_human Association of tumor necrosis factor β genetic polymorphism and sepsis susceptibility. 22977509 2011
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis
0.360 GeneticVariation disease BEFREE Association between lymphotoxin-alpha (tumor necrosis factor-beta) intron polymorphism and predisposition to severe sepsis is modified by gender and age. 19789445 2010
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis
0.360 GeneticVariation disease BEFREE Several genetic polymorphisms have been identified in patients with sepsis and severe sepsis, such as the tumor necrosis factor-alpha (TNF-alpha) and TNF-beta genes, the interleukin-1 (IL-1) family, the IL-6, the IL-10, the CD-14, the Toll-like receptors, plasminogen activator inhibitor type 1, and the factor V 1691G-A mutations. 16444434 2006
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis
0.360 GeneticVariation disease BEFREE Concerning the LT-alpha-genotypes, there was no difference in the frequency of severe sepsis or shock or in the development of multi-organ failure or death between the three subgroups. 15187748 2004
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis
0.360 GeneticVariation disease BEFREE Analysis of a possible linkage between HSP70 and TNF-beta genotypes resulted in a significant association (odds ratio, 4.15; p < .01) of the HSP70-2 A/A homozygous genotype and the TNFB2/B2 homozygous genotype, which is reported to be a genomic marker for a poor prognosis in severe sepsis. 10446818 1999
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis
0.360 GeneticVariation disease BEFREE To investigate the relation of the biallelic Nco1 restriction fragment length polymorphism in the first intron of the tumor necrosis factor (TNF) beta gene with the development of severe sepsis in multiply injured patients. 10450735 1999