|
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
TNF-α -308 (G/A), and TNF-β +252 (A/G) haplotype "GG" "AG" increased CAD risk significantly (GG haplotype, adjusted OR=2.6, CI 1.4-5.0, p=0.003 and AG haplotype OR=8.5, CI 2.2-33.35, p=0.002) after adjustments for age, sex, TC, TG, HDL, APOB, smoking and diet.
|
28739396 |
2017 |
|
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We therefore investigated the relationship between four SNPs of LTA gene and CAD in Han Chinese: G+10A (rs1800683, 5'-untranslated region), A+80C (rs2239704, 5'-untranslated region), T+496C (rs2229094" genes_norm="4049">Cys13Arg, rs2229094, exon 2), and C+804A (rs1041981" genes_norm="4049">Thr26Asn, rs1041981, exon 3).
|
21628868 |
2011 |
|
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
No population significant differences were detected in LTA genotypes and allele frequencies between coronary heart disease patients or healthy controls (chi(2) = 1.479, P = 0.477 > 0.05).
|
19365711 |
2010 |
|
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In present study, the LTA gene and LGALS2-C3279T are not associated with coronary artery disease.
|
19726041 |
2010 |
|
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
LHGDN |
Lymphotoxin-alpha3 mediates monocyte-endothelial interaction by TNFR I/NF-kappaB signaling.
|
19103156 |
2009 |
|
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the major finding of this study is that the LTA+496C allele is associated with periodontitis in patients with CAD.
|
18384488 |
2008 |
|
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Effects of lymphotoxin-alpha gene and galectin-2 gene polymorphisms on inflammatory biomarkers, cellular adhesion molecules and risk of coronary heart disease.
|
17040205 |
2007 |
|
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Clinical, genetic, and epidemiological studies have linked lymphotoxin-alpha (LTA), a proinflammatory cytokine, to coronary artery disease and myocardial infarction.
|
18190265 |
2007 |
|
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated the influence of the LTA 252A>G and 804C>A polymorphisms on circulating parameters related to metabolic syndrome in Korean patients with CAD.
|
17640627 |
2007 |
|
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Thus, further to the recent finding that LTA gene variation is associated with susceptibility to coronary heart disease, the present study provides evidence of an association between LTA genotype and the extent of coronary atherosclerosis.
|
15973460 |
2005 |
|
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Thus, further to the recent finding that LTA gene variation is associated with susceptibility to coronary heart disease, the present study provides evidence of an association between LTA genotype and the extent of coronary atherosclerosis.
|
15973460 |
2005 |
|
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A trio family study showing association of the lymphotoxin-alpha N26 (804A) allele with coronary artery disease.
|
15266304 |
2004 |
|
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
CTD_human |
A trio family study showing association of the lymphotoxin-alpha N26 (804A) allele with coronary artery disease.
|
15266304 |
2004 |
|
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that six different and functionally relevant polymorphisms of the genes coding for IL-10, TNF-alpha, and TNF-beta are neither separately nor in cooperation associated with the risk of CAD or MI in angiographically examined patients.
|
11689215 |
2001 |
|
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genomic variants of TNF-beta may therefore contribute to the complex susceptibility for the metabolic syndrome in patients with CAD.
|
9726033 |
1998 |