Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
0.100 Biomarker disease BEFREE Surprisingly however, NHD13 transgenic mice lacking Lyl1 showed accelerated T-ALL and absence of transformation to AML, associated with a loss of multipotent progenitors in the bone marrow. 30700838 2019
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
0.100 Biomarker disease BEFREE Our data provide insight into the mechanisms controlling lymphocyte specification and may reveal a basis for the unique functions of Tal1 and Lyl1 in T acute lymphoblastic leukemia. 30962294 2019
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
0.100 Biomarker disease BEFREE Thus, the LMO2-LYL1 interaction is a promising therapeutic target for inhibiting self-renewing cancer stem cells in T-ALL, including poor-prognosis ETP-ALL cases. 23926305 2013
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
0.100 Biomarker disease BEFREE In hematopoiesis, the two major bHLH factors are stem cell leukemia (SCL) and lymphoblastic leukemia-derived sequence 1 (LYL1), both identified more than 20 years ago in chromosomal translocations occurring in T-cell acute lymphoblastic leukemia. 22593015 2012
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
0.100 GeneticVariation disease BEFREE Molecular characterization of a t(7;19)(q34;p13) in a pediatric T-cell acute lymphoblastic leukemia patient led to the identification of a translocation between the TRB@ and LYL1 loci. 22058201 2012
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
0.100 AlteredExpression disease BEFREE TAL1, LYL1, HOX11 and other transcription factors essential for normal hematopoiesis are often misexpressed in the thymus in T-cell acute lymphoblastic leukemia (T-ALL), leading to differentiation arrest and cell transformation. 17934490 2007
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
0.100 AlteredExpression disease BEFREE LYL1, a member of the class II basic helix-loop-helix transcription factors, is aberrantly expressed in a fraction of human T-cell acute lymphoblastic leukemia. 17486074 2007
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
0.100 Biomarker disease BEFREE The LYL1 gene encodes a basic helix-loop-helix transcription factor involved in T-cell acute lymphoblastic leukemia. 16094422 2005
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
0.100 Biomarker disease BEFREE TAL2 potentially encodes a basic helix-loop-helix motif that is highly related to those specified by TAL1 and LYL1, distinct genes that have also been implicated in T-ALL. 8152805 1994
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
0.100 GeneticVariation disease BEFREE The bHLH domain of TAL1 is especially homologous to those encoded by TAL2 and LYL1, distinct genes that were also identified on the basis of chromosomal rearrangement in T-ALL. 8142619 1993
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
0.100 Biomarker disease BEFREE Hence, TAL2, TAL1, and LYL1 constitute a discrete subgroup of helix-loop-helix proteins, each of which can potentially contribute to the development of T-ALL. 1763056 1991
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
0.100 GeneticVariation disease BEFREE The E2A gene is involved by the t(1;19)(q23;p13) in acute pre-B-cell leukemias and the LYL1 gene is structurally altered by a t(7;19)(q34;p13) in T-cell ALL. 2268576 1990