MIR34A, microRNA 34a, 407040

N. diseases: 428; N. variants: 5
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0015695
Disease: Fatty Liver
Fatty Liver
0.360 Biomarker disease BEFREE Amelioration of hepatic steatosis is associated with modulation of gut microbiota and suppression of hepatic miR-34a in <i>Gynostemma pentaphylla</i> (Thunb.) Makino treated mice. 30555521 2018
CUI: C0015695
Disease: Fatty Liver
Fatty Liver
0.360 Biomarker disease BEFREE Dysregulation of circRNA_0046366/miR-34a/PPARα signaling may be a novel epigenetic mechanism underlying hepatocellular steatosis. circRNA_0046366 serves as a potential target for the treatment of hepatic steatosis. 29391755 2018
CUI: C0015695
Disease: Fatty Liver
Fatty Liver
0.360 Biomarker disease BEFREE Activating AMPK<i>α</i> negatively regulates Egr1 to inhibit inflammatory cytokines in high glucose. miR-34a inhibition increases phosphorylated AMPK<i>α</i> through mediating SIRT1 to suppress the development of fatty liver. 29681936 2018
CUI: C0015695
Disease: Fatty Liver
Fatty Liver
0.360 Biomarker disease BEFREE These findings indicate a circRNA_0046367/miR-34a/PPAR<i>α</i> regulatory system underlying hepatic steatosis. 29018509 2017
CUI: C0015695
Disease: Fatty Liver
Fatty Liver
0.360 Biomarker disease BEFREE Here we show that hepatocyte nuclear factor 4α (HNF4α), a liver-enriched nuclear hormone receptor, is markedly inhibited, whereas miR-34a is highly induced in patients with non-alcoholic steatohepatitis, diabetic mice and mice fed a high-fat diet. miR-34a is essential for HNF4α expression and regulates triglyceride accumulation in human and murine hepatocytes. miR-34a inhibits very low-density lipoprotein secretion and promotes liver steatosis and hypolipidemia in an HNF4α-dependent manner. 26100857 2015
CUI: C0015695
Disease: Fatty Liver
Fatty Liver
0.360 Biomarker disease CTD_human Elevated microRNA-34a in obesity reduces NAD+ levels and SIRT1 activity by directly targeting NAMPT. 23834033 2013
CUI: C0015695
Disease: Fatty Liver
Fatty Liver
0.360 Biomarker disease BEFREE p53 and its transcriptional target miRNA34a have been implicated in the pathogenesis of fatty liver. 23211317 2013