Pancreatic Neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The findings implicate epithelial tension and matricellular fibrosis in the aggressiveness of SMAD4 mutant pancreatic tumors and highlight STAT3 and mechanics as key drivers of this phenotype.
|
27089513 |
2016 |
Pancreatic Neoplasm
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
DPC4/SMAD4 mutations are associated with aggressive pancreatic cancer.In this issue of Cell, Whittle et al. demonstrate that Runx3 expression combined with Dpc4/Smad4 status can predict the metastatic propensity of pancreatic tumors, providing valuable guidance for personalized therapy for patients with pancreatic cancer.
|
26046433 |
2015 |
Pancreatic Neoplasm
|
0.700 |
Biomarker
|
disease |
BEFREE |
SMAD4 is a gastrointestinal malignancy-specific tumor suppressor gene found mutated in one third of colorectal cancer specimens and half of pancreatic tumors.
|
24625091 |
2014 |
Pancreatic Neoplasm
|
0.700 |
Biomarker
|
disease |
BEFREE |
We previously reported that Smad4-negative pancreatic tumors contain fewer stromal S100A8-positive monocytes than their Smad4-positive counterparts.
|
20622003 |
2010 |
Pancreatic Neoplasm
|
0.700 |
Biomarker
|
disease |
BEFREE |
We showed that the absence of Smad4 alone did not trigger pancreas tumor formation; however, it increased the expression of an inactivated form of Pten, suggesting a role of Pten in preventing Smad4-/- cells from undergoing malignancy.
|
19901970 |
2010 |
Pancreatic Neoplasm
|
0.700 |
AlteredExpression
|
disease |
LHGDN |
Inhibition of STAT3 Tyr705 phosphorylation by Smad4 suppresses transforming growth factor beta-mediated invasion and metastasis in pancreatic cancer cells.
|
18519681 |
2008 |
Pancreatic Neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We show here that concomitant expression of Kras(G12D) and haploinsufficiency of the Smad4/Dpc4 tumor suppressor gene engenders a distinct class of pancreatic tumors, mucinous cystic neoplasms (MCNs), which culminate in invasive ductal adenocarcinomas.
|
17349581 |
2007 |
Pancreatic Neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Mutation or deletion of Smad4 is found in about 50% of pancreatic tumors and in about 15% of colorectal tumors.
|
16135802 |
2005 |
Pancreatic Neoplasm
|
0.700 |
AlteredExpression
|
disease |
LHGDN |
Immortalizing the complexity of cancer metastasis: genetic features of lethal metastatic pancreatic cancer obtained from rapid autopsy.
|
15846069 |
2005 |
Pancreatic Neoplasm
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Missense mutations of MADH4: characterization of the mutational hot spot and functional consequences in human tumors.
|
15014009 |
2004 |
Pancreatic Neoplasm
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Therefore, DPC4 inactivation by mutation or deletion appears to be very rare in PET, which confirms the current concept of unrelated mechanisms of tumorigenesis of endocrine versus exocrine pancreatic tumors.
|
14639103 |
2003 |
Pancreatic Neoplasm
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
[Alterations in DPC4 gene in pancreatic cancers].
|
11783110 |
2001 |
Pancreatic Neoplasm
|
0.700 |
Biomarker
|
disease |
BEFREE |
Loss of Smad4 function in pancreatic tumors: C-terminal truncation leads to decreased stability.
|
11553622 |
2001 |
Pancreatic Neoplasm
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Mutations of the DPC4/Smad4 gene in neuroendocrine pancreatic tumors.
|
10327057 |
1999 |
Pancreatic Neoplasm
|
0.700 |
CausalMutation
|
disease |
CGI |
|
|
|
Pancreatic Neoplasm
|
0.700 |
Biomarker
|
disease |
CTD_human |
|
|
|
Pancreatic Neoplasm
|
0.700 |
GenomicAlterations
|
disease |
CGI |
|
|
|
Pancreatic Neoplasm
|
0.700 |
Biomarker
|
disease |
HPO |
|
|
|