|
Antisocial Personality Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Finally, the density of monoamine oxidase-A (MAO-A), a mitochondrial enzyme that degrades 5-HT, norepinephrine, and dopamine (DA), was reported as lower in the OFC and ventral striatum of ASPD.
|
30852703 |
2019 |
|
Antisocial Personality Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The independent variable being manipulated is the type of information supporting the expert diagnosis: either no biological explanation of "psychopathy" versus a neurological explanation (brain injury) versus a genetic explanation (MAOA gene).
|
31681122 |
2019 |
|
Antisocial Personality Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
There was no evidence for an interaction effect between MAOA uVNTR genotype and childhood trauma on psychopathy in either gender.
|
29843018 |
2018 |
|
Antisocial Personality Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Consistent with hypotheses, females with high-activity MAOA genotype who experienced early maltreatment had greater increases in ER during adolescence, and higher levels of ER predicted both antisocial personality disorder and borderline personality disorder symptom severity.
|
29467046 |
2018 |
|
Antisocial Personality Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that monoamine oxidase A genotype may affect corticostriatal connectivity in antisocial personality disorder and that these functional connections may also underlie use of proactive aggression in a genotype-specific manner.
|
29746646 |
2018 |
|
Antisocial Personality Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
However, it is currently unknown whether amygdala and OFC morphology in ASPD relate to MAO-A genetic polymorphisms.
|
28851912 |
2017 |
|
Antisocial Personality Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Platelet MAO-B activity has been associated with psychopathy- and aggression-related personality traits, while variants of the MAOA and MAOB genes have been associated with diverse clinical phenotypes, including aggressiveness, antisocial problems and violent delinquency.
|
26851573 |
2016 |
|
Antisocial Personality Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The Influence of Nutritional Factors on Verbal Deficits and Psychopathic Personality Traits: Evidence of the Moderating Role of the MAOA Genotype.
|
26690459 |
2015 |
|
Antisocial Personality Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Results suggest that MAOA promoter hypermethylation is associated with ASPD and may contribute to downregulation of MAOA gene expression, as indicated by functional assays in vitro, and regression analysis with whole-blood serotonin levels in offenders with ASPD.
|
25497297 |
2015 |
|
Antisocial Personality Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Consequently, we examined how serotonin transporter (5-HTTLPR) polymorphisms, monoamine oxidase-A (MAO-A) variants, and childhood abuse measured with the Childhood Trauma Questionnaire relate to dimensions of psychopathy in a forensic sample of 237 men with elevated levels of environmental adversity.
|
22985017 |
2013 |
|
Antisocial Personality Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The high-activity MAOA allele is protective against ASP among whites with no history of physical abuse, lending support to a link between MAOA expression and antisocial behavior.
|
21295226 |
2011 |
|
Antisocial Personality Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Gene environment interactions with a novel variable Monoamine Oxidase A transcriptional enhancer are associated with antisocial personality disorder.
|
21554924 |
2011 |
|
Antisocial Personality Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Regression analysis was used to evaluate the alcohol exposure and age-adjusted effect of PCL-R score and psychopathy on the risk for reconvictions among differing MAOA genotypes.
|
20850185 |
2011 |
|
Antisocial Personality Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
We conclude that the Gene x Environment interplay at this locus (MAOA) contributes to both symptoms of ASPD and MD and that careful specification of child maltreatment may be essential if genetic association research is to produce replicable results.
|
20175604 |
2010 |
|
Antisocial Personality Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
A significant main effect of genotype on risk for CD was detected, where low-activity MAOA imparted the greatest risk to CD in girls while controlling for the significant effects of maternal ASP and childhood adversity.
|
18752729 |
2009 |
|
Antisocial Personality Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The objective of this study is to determine whether the interaction between the MAOA and the ALDH2 genes is associated with subjects with antisocial personality disorder (ASPD) having alcoholism.
|
19302089 |
2009 |
|
Antisocial Personality Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
MAOA and 5HTT variants were associated with total psychopathy scores.
|
19829167 |
2009 |
|
Antisocial Personality Disorder
|
0.400 |
Biomarker
|
disease |
CTD_human |
The VNTR 2 repeat in MAOA and delinquent behavior in adolescence and young adulthood: associations and MAOA promoter activity.
|
18212819 |
2008 |
|
Antisocial Personality Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We examined the possible joint effects of testosterone (measured in CSF) and MAOA-LPR genotype on antisocial personality disorder and scores on the Brown-Goodwin Aggression scale in 95 unrelated male criminal alcoholics and 45 controls.
|
17429405 |
2008 |
|
Antisocial Personality Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Sequence analysis of exon 8 of MAO-A gene in alcoholics with antisocial personality and normal controls.Genomics.
|
17007976 |
2007 |
|
Antisocial Personality Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The repeat number of the MAO-A polymorphism was assessed in 199 male subjects of Italian descent, a sample comprising 95 healthy subjects and 104 heroin-dependent subjects including 52 addicted individuals with violent behaviour and antisocial personality disorder.
|
15088154 |
2004 |
|
Antisocial Personality Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
No association between a polymorphism in the promoter region of the MAOA gene with antisocial personality traits in alcoholics.
|
12554604 |
2003 |
|
Antisocial Personality Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Thus, neither antisocial alcoholism nor antisocial personality disorder was associated with the genetic variants of MAO-A gene.
|
12824808 |
2003 |
|
Antisocial Personality Disorder
|
0.400 |
Biomarker
|
disease |
CTD_human |
Role of genotype in the cycle of violence in maltreated children.
|
12161658 |
2002 |
|
Antisocial Personality Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To determine the possible role of any mutation in exon 8 of the MAO-A gene in susceptibility to alcoholism associated with antisocial personality (ASP), we sequenced genomic DNA from 50 alcoholics and 50 normal controls.
|
10049583 |
1999 |