Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The monoamine oxidase A (MAO-A) represents an important target for antidepressant treatments and was found to be increased in MDD.
|
30635228 |
2019 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recent human brain imaging studies implicate dysregulation of monoamine oxidase-A (MAO-A), in particular in the prefrontal cortex (PFC) and anterior cingulate cortex (ACC), in the development of major depressive disorder (MDD).
|
28435083 |
2017 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This paper attempts to provide a comprehensive review of available imaging genetics studies, including reports on genetic variants that have most frequently been linked to MDD, such as the monoaminergic genes (serotonin transporter gene, monoamine oxidase A gene, tryptophan hydroxylase-2 gene, serotonin receptor 1A gene and catechol-O-methyl transferase gene), with regard to key structures involved in emotion processing, such as the hippocampus, amygdala, anterior cingulate cortex and orbitofrontal cortex.
|
25828849 |
2016 |
Major Depressive Disorder
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
94 patients of Caucasian descent with major depressive disorder (f = 61; DSM-IV) were analyzed for DNA methylation status at 43 MAO-A CpG sites via direct sequencing of sodium bisulfite treated DNA extracted from blood cells.
|
24809685 |
2015 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
94 patients of Caucasian descent with major depressive disorder (f = 61; DSM-IV) were analyzed for DNA methylation status at 43 MAO-A CpG sites via direct sequencing of sodium bisulfite treated DNA extracted from blood cells.
|
24809685 |
2015 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results serve to assign an important role of KLF11 in upregulating MAO A in MDD and chronic social stress, suggesting that inhibition of the pathways regulated by this transcription factor may aid in the therapeutics of neuropsychiatric illnesses.
|
25502632 |
2015 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
We detected allelic or genotypic associations of MAOA, TPH1, FKBP5 and BDNF in clinically significant MDD in AD.
|
23157339 |
2013 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
TPH1, MAOA, serotonin receptor 2A and 2C genes in citalopram response: possible effect in melancholic and psychotic depression.
|
23221997 |
2013 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
There was an increased risk of having MDD in homozygous female carriers of the TPH1 A-allele (odds ratio: 4.35) and homozygous carriers of the MAOA VNTR low activity allele 3R (odds ratio: 3.37).
|
23157339 |
2013 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Low-activity MAOA genotype buffered against symptoms of dysthymia, major depressive disorder, and alcohol abuse for sexually abused white participants.
|
22030358 |
2012 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The MAOA 4R allele was more frequent in males with MDD than in male community controls (χ2 = 4.182, p = 0.041).
|
21605465 |
2011 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Consistent with the change in MAO A protein expression, the MAO A catalytic activity was significantly greater in both MDD groups compared with controls.
|
21654740 |
2011 |
Major Depressive Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Consistent with the change in MAO A protein expression, the MAO A catalytic activity was significantly greater in both MDD groups compared with controls.
|
21654740 |
2011 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
We analyzed 62 genotyped variants within the selected genes (BDNF, NTRK2, SLC6A4, TPH2, P2RX7, DAOA, COMT, DISC1, and MAOA) against the presence of mood disorder, and in post-hoc analyses, specifically against bipolar disorder or major depressive disorder.
|
21438144 |
2011 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
We conclude that the Gene x Environment interplay at this locus (MAOA) contributes to both symptoms of ASPD and MD and that careful specification of child maltreatment may be essential if genetic association research is to produce replicable results.
|
20175604 |
2010 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our meta-analysis suggests a significant association of the MAOA gene with major depressive disorder and BPD within specific groups, indicating that these three polymorphisms of the MAOA gene may be associated with mood disorders by sex and ethnicity.
|
20010318 |
2010 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Despite the fact that the contribution of the "genome" remains elusive when it comes to major depression, intriguing evidence has recently emerged pointing to sexually dimorphic influences of certain polymorphisms in genes related to the pathophysiology of major depression and antidepressant response, such as the serotonin transporter (5-HTT), serotonin 1A (5HT1A) receptor, monoamine oxidase A (MAO-A) and others.
|
20459391 |
2010 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Quantitative real-time polymerase chain reaction analysis showed that overall relative quantity of MAOA messenger RNA was significantly higher in patients with MDD than in control subjects (fold change = 5.28, p = 1.7 × 10⁻⁷) and that in the male subjects carrying the VNTR-L, rs1465107-A, rs6323-G, rs2072743-A, or rs1137070-T alleles, expression of MAOA messenger RNA was significantly higher in the patient group than in the control group.
|
20691428 |
2010 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Monoamine oxidase A and B (MAOA and MAOB) appear to be involved in the pathogenesis of Major Depression, and vulnerability of Major Depression is associated with personality traits relating to positive and negative affect.
|
19657584 |
2009 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The results suggest that MAOA polymorphisms do not play a major role in the pathogenesis of MDD or its subgroups.
|
19224413 |
2009 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
MAOA gene polymorphisms and response to mirtazapine in major depression.
|
19382113 |
2009 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Monoamine oxidase a and catechol-o-methyltransferase functional polymorphisms and the placebo response in major depressive disorder.
|
19593178 |
2009 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We conclude that genetic variation in the MAOA gene may affect the course of major depression by disrupting cortico-limbic connectivity.
|
18544183 |
2009 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The present results suggest that high-activity MAO-A genotypes possibly by consecutively decreased serotonin and/or norepinephrine availability negatively influence antidepressant treatment response during the first six weeks of pharmacological treatment in female patients with Major Depression.
|
17884271 |
2008 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Major depressive disorder is a mediating factor between the monoamine oxidase A promoter polymorphism and telomeric length.
|
17417064 |
2007 |