Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
A set of 41 SNPs of genes for dopamine receptors DRD1, DRD2, DRD3, DRD4, the dopamine transporter SLC6A3 and dopamine catabolizing enzymes MAOA and MAOB was investigated in a population of 446 Caucasians (221 males/225 females) with a clinical diagnosis of schizophrenia (according to ICD-10: F20) with and without HPRL who were treated with classical and/or atypical antipsychotic drugs.
|
30967134 |
2019 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Midbrain monoamine oxidase A (MAOA) mRNA was increased, whereas MAOB and catechol-O-methyl transferase mRNAs were unchanged in schizophrenia.
|
28094812 |
2017 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
No significant association was found between severe agitation and MAOA uVNTR or MAOB rs1799836 polymorphism, revealing that these individual polymorphisms in MAO genes are not related to severe agitation in subjects with schizophrenia and conduct disorder.
|
26851573 |
2016 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The strongest association (p = 0.0004) was found between MAOB rs5905512, a SNP previously reported to be associated with schizophrenia in men, and MHPG concentrations in men with psychotic disorder.
|
25073638 |
2014 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results provide additional evidence that GABRB3 and MAOB/NDP gene regions might constitute risk factors for hallucinations and delusions in schizophrenia.
|
22414661 |
2012 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Hum Mol Genet 2008) and the monoamine degradation enzyme monoamine oxidase B were found in ASD and SCZ, respectively.
|
20479760 |
2011 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Here, we investigated the association of MAOA and MAOB polymorphisms with schizophrenia in a Han Chinese population.
|
21978760 |
2011 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
CTD_human |
Hum Mol Genet 2008) and the monoamine degradation enzyme monoamine oxidase B were found in ASD and SCZ, respectively.
|
20479760 |
2011 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These data do not suggest that the MAOA gene VNTR and MAOB gene A644G polymorphisms are associated with antipsychotic-induced RLS symptoms in schizophrenia.
|
20589923 |
2010 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
We present a schizophrenia association study using an extensive linkage disequilibrium (LD) mapping approach in seven candidate genes with a well established link to dopamine, including receptors (DRD2, DRD3) and genes involved in its metabolism and transport (ACE, COMT, DAT, MAO-A, MAO-B).
|
19508883 |
2009 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
We tested four genes [phenylalanine hydroxylase (PAH), the serotonin transporter (SLC6A4), monoamine oxidase B (MAOB), and the gamma-aminobutyric acid A receptor beta-3 subunit (GABRB3)] for their impact on five schizophrenia symptom factors: delusions, hallucinations, mania, depression, and negative symptoms.
|
19268543 |
2009 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results support the involvement of the MAO-B gene in schizophrenia, particularly in women.
|
18832861 |
2008 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We examined the relationship between Overt aggression scale (OAS) scores, and both MAOA and MAOB polymorphisms in a well-powered sample of 346 subjects with schizophrenia.
|
15211623 |
2004 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We genotyped the valine/methionine polymorphism of codon 108/158 in the catechol-O-methyltransferase (COMT) gene, the 30-bp repeat polymorphism in the promoter of the monoamine oxidase A (MAOA) gene, and the A/G polymorphism in intron 13 of the monoamine oxidase B (MAOB) gene in 206 Japanese patients with schizophrenia.
|
15261699 |
2004 |
Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We found two genes differentially expressed: monoamine oxidase B was significantly increased in schizophrenia brain (p =.001), whereas one of the serotonin receptor genes, serotonin receptor 2C, was significantly decreased (p =.001).
|
14643089 |
2003 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The present findings suggest that linkage disequilibrium between polymorphic loci for human MAO-A and MAO-B may be associated with schizophrenia, and the (AC)18/(TG)23 haplotype may render an individual more vulnerable to such an illness.
|
10697823 |
1999 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
No sequence changes of likely functional significance were identified, suggesting that mutations affecting the structure of the MAO-B protein are uncommon in the general population and are unlikely to contribute significantly to the genetic predisposition to schizophrenia.
|
9034005 |
1997 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A linkage study of schizophrenia to markers within Xp11 near the MAOB gene.
|
9211575 |
1997 |
Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Decreased levels of platelet MAO-B activity has been reported in patients with schizophrenia and genetic variation in MAO activity had been proposed as a significant factor in the etiology of this disease.
|
8804132 |
1996 |