|
Cognition Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β and tau proteins, which are believed to lead to neural damage that translates into brain dysfunction and cognitive deficits.
|
30599271 |
2019 |
|
Cognition Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
For the accumulation of intracellular hyperphosphorylated tau proteins is a major pathogenic factor in neurodegeneration of AD, the distributional pattern of tau could highlight the affected brain regions associated with specific cognitive deficits.
|
31724513 |
2019 |
|
Cognition Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Amyloid-β (Aβ) and hyperphosphorylated Tau protein (P-Tau) (the main AD neuropathological features) affect and are affected by peripheral and brain insulin signalling dysfunction, leading to glucose dysmetabolism, synaptic loss and AD-related cognitive deficits.
|
29471055 |
2018 |
|
Cognition Disorders
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In this regard, CPF induces Aβ and tau proteins production and activation of GSK3β enzyme and alters glutamatergic transmission, which have been related with basal forebrain cholinergic neuronal cell death and development of cognitive disorders.
|
29665406 |
2018 |
|
Cognition Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Alzheimer's disease (AD) is associated with cerebral cognitive deficits exhibiting two cardinal hallmarks: accruement of extracellular amyloid plaques and intracellular neurofibrillary tangles composed of hyperphosphorylated tau protein.
|
30223691 |
2018 |
|
Cognition Disorders
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Increased levels of amyloid and tau-proteins correlate with cognitive decline and may have prognostic value for cognitive deficits in PD.
|
26991855 |
2017 |
|
Cognition Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
EA significantly improved cognitive deficits and reduced Aβ and p-Tau Ser404 protein concentrations in the hippocampal CA1 region.
|
27401747 |
2017 |
|
Cognition Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The microtubule-associated protein tau (MAPT, tau) forms neurotoxic aggregates that promote cognitive deficits in tauopathies, the most common of which is Alzheimer's disease (AD).
|
28827321 |
2017 |
|
Cognition Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Chronic stress, a well-known inducer of neuronal/synaptic atrophy, triggers hyperphosphorylation of Tau protein and cognitive deficits.
|
27073221 |
2017 |
|
Cognition Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Alzheimer's Disease (AD) is a progressive neurodegenerative disorder characterized by extracellular plaques containing abnormal Amyloid Beta (Aβ) aggregates, intracellular neurofibrillary tangles containing hyperphosphorylated tau protein, microglia-dominated neuroinflammation, and impairments in synaptic plasticity underlying cognitive deficits.
|
27486879 |
2016 |
|
Cognition Disorders
|
0.400 |
Biomarker
|
group |
CTD_human |
Long-term exposure to ELF-MF ameliorates cognitive deficits and attenuates tau hyperphosphorylation in 3xTg AD mice.
|
26945731 |
2016 |
|
Cognition Disorders
|
0.400 |
Biomarker
|
group |
CTD_human |
Methylene blue upregulates Nrf2/ARE genes and prevents tau-related neurotoxicity.
|
24556215 |
2014 |
|
Cognition Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Two pairs of siblings with FTDP-17 were longitudinally examined for agraphia in relation to language and cognitive deficits.
|
23121543 |
2014 |
|
Cognition Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We aimed to investigate whether cognitive deficits and structural and functional connectivity changes can be detected before symptom onset in a large cohort of carriers of MAPT (microtubule-associated protein tau) or GRN (progranulin) mutations.
|
25002573 |
2014 |
|
Cognition Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We aimed to investigate whether cognitive deficits and structural and functional connectivity changes can be detected before symptom onset in a large cohort of carriers of microtubule-associated protein tau and progranulin mutations.
|
23390180 |
2013 |
|
Cognition Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Baseline predictors of dementia were age, motor impairment, 'posterior-cortical' cognitive deficits and MAPT genotype.
|
23781007 |
2013 |
|
Cognition Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Recurrent microdeletions of this region including the MAPT and the CHRH1 genes have been shown to be a relatively frequent cause of intellectual disability, while only a few reciprocal duplications in patients with variable cognitive disorders have been published so far.
|
22678764 |
2012 |
|
Cognition Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The behavioral phenotype of N279K mice mimics features of human FTDP-17 and provides a basic model for elucidating mechanisms underlying cognitive deficits in not only FTDP-17, but also diverse tauopathies.
|
16219306 |
2005 |