MAPT, microtubule associated protein tau, 4137

N. diseases: 469; N. variants: 292
Disease: Memory impairment ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.500 Biomarker phenotype BEFREE Mice receiving endothelium-derived amyloid and tau proteins <i>via</i> intracerebroventricular injection exhibit a learning and memory deficit in object recognition, fear conditioning, and Morris water maze studies. 31211919 2019
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.500 AlteredExpression phenotype BEFREE The data observed show that neonatal immune activation may be associated with visuospatial memory impairment, neuroinflammation, and increased expression of GSK-3<i>β</i> and Tau proteins in the long term. 31467920 2019
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.500 GeneticVariation phenotype BEFREE Uncleavable SRPK2 N342A expression improves synaptic functions and prevents spatial memory deficits in tau intronic mutant FTDP-17 transgenic mice. 30373880 2018
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.500 Biomarker phenotype CTD_human Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy. 29860433 2018
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.500 Biomarker phenotype BEFREE Study of molecular mechanisms of learning and memory impairment in neonatal rats post intrauterine distress via the pathway of Tau protein hyperphosphorylation. 29771431 2018
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.500 Biomarker phenotype CTD_human Importance of tau in cognitive decline as revealed by developmental exposure to lead. 29203278 2018
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.500 Biomarker phenotype BEFREE However, the exact mechanism through which arctigenin improves amyloid beta-induced memory impairment by inhibiting the production of the hyperphosphorylated tau protein is unknown. 27224270 2017
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.500 Biomarker phenotype BEFREE The associations between the loops and behaviours further suggest that tau protein pathway genes do play a significant role in non-episodic memory impairment. 25344117 2016
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.500 Biomarker phenotype CTD_human Methylene blue upregulates Nrf2/ARE genes and prevents tau-related neurotoxicity. 24556215 2014
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.500 GeneticVariation phenotype BEFREE We show for the first time that hippocampal GABAergic function is impaired by pathological tau protein, leading to altered synaptic plasticity and severe memory deficits. 24252661 2013
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.500 Biomarker phenotype CTD_human A proteomic analysis of MCLR-induced neurotoxicity: implications for Alzheimer's disease. 22430071 2012
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.500 Biomarker phenotype BEFREE At clinical presentation, familial FTLD-TDP patients were older at onset (p = 0.030) and had more memory deficits (p = 0.011), whereas patients with MAPT had more naming deficits (p < 0.001) and obsessive-compulsive behavior (p = 0.001). 21753175 2011
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.500 Biomarker phenotype BEFREE SuHeXiang Wan essential oil alleviates amyloid beta induced memory impairment through inhibition of tau protein phosphorylation in mice. 21905282 2011
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.500 Biomarker phenotype BEFREE Alzheimer's disease (AD) is defined by senile plaques made of amyloid-beta peptide (Abeta), neurofibrillary tangles made of hyperphosphorylated tau proteins, and memory deficits. 20463407 2010
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.500 Biomarker phenotype CTD_human Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau. 12368474 2002
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.500 Biomarker phenotype HPO
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.500 CausalMutation phenotype CLINVAR