Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Misfolding and aggregate formation by the tau protein has been closely related with neurotoxicity in a large group of human neurodegenerative disorders, which includes Alzheimer's disease.
|
31521630 |
2020 |
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Tauopathies such as Alzheimer's disease (AD), Pick's disease (PiD), Frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) etc. represent a group of age-related neurodegenerative disorders in which tau protein loses its normal conformation mostly due to hyperphosphorylation and subsequent formation of the aggregates of defined shapes, known as Neurofibrillary Tangles (NFTs).
|
31715291 |
2020 |
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Tauopathies are a class of neurodegenerative diseases that are characterized by pathological aggregation of tau protein, which is accompanied by synaptic disorders.
|
30809933 |
2019 |
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The accumulation of tau protein aggregates is a pathological hallmark in Alzheimer's disease (AD) and other neurodegenerative diseases.
|
30814358 |
2019 |
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Four-repeat (4R-) tauopathies are a group of neurodegenerative diseases defined by cytoplasmic inclusions predominantly composed of tau protein isoforms with four microtubule-binding domains.
|
31238088 |
2019 |
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Alzheimer's disease is a neurodegenerative disorder characterized by extracellular deposition of amyloid-β (Aβ) peptide and hyperphosphorylation of Tau protein, which ultimately leads to the formation of intracellular neurofibrillary tangles and cell death.
|
31795012 |
2019 |
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The assembly of tau protein into abnormal filaments and brain cell degeneration are characteristic of a number of human neurodegenerative diseases, including Alzheimer's disease and frontotemporal dementia and parkinsonism linked to chromosome 17.
|
30905766 |
2019 |
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Hyperphosphorylation of the microtubule-associated protein tau and its resultant aggregation into neurofibrillary tangles (NFT) is a pathological characteristic of neurodegenerative disorders known as tauopathies.
|
31780921 |
2019 |
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Tauopathies are a class of neurodegenerative diseases characterized by the presence of pathological intracellular deposits of Tau proteins.
|
31522011 |
2019 |
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Alzheimer's Disease (AD) is an age-dependent neurodegenerative disorder, the most common type of dementia that is clinically characterized by the presence of beta-amyloid (Aβ) extracellularly and intraneuronal tau protein tangles that eventually leads to the onset of memory and cognition impairment, development of psychiatric symptoms and behavioral disorders that affect basic daily activities.
|
31642777 |
2019 |
Neurodegenerative Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Mutations in the microtubule-associated protein tau (MAPT) underlie multiple neurodegenerative disorders, yet the pathophysiological mechanisms are unclear.
|
30590647 |
2019 |
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Human tauopathies are neurodegenerative diseases with accumulation of abnormally phosphorylated and aggregated tau proteins forming neurofibrillary tangles.
|
31306814 |
2019 |
Neurodegenerative Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In addition, Tau gene mutations, aberrant mRNA splicing and abnormal post-translational modifications, such as hyperphosphorylation, lead to formation of pathological, insoluble Tau aggregates that are a hallmark of neurodegenerative diseases, collectively known as tauopathies.
|
30550860 |
2019 |
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Tauopathies, a class of neurodegenerative diseases that includes Alzheimer's disease (AD), are characterized by the deposition of neurofibrillary tangles composed of hyperphosphorylated tau protein in the human brain.
|
31436053 |
2019 |
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Abnormal folding and aggregation of the microtubule-associated protein, tau, is a hallmark of several neurodegenerative disorders, including Alzheimer's disease (AD).
|
31524157 |
2019 |
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Neurodegenerative diseases such as Alzheimer's disease are characterized by the progressive spreading and accumulation of hyper-phosphorylated tau protein in the brain.
|
30874605 |
2019 |
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
We hypothesized that intermediate C9orf72 repeats are a genetic risk factor for corticobasal degeneration (CBD), a neurodegenerative disease that can be clinically similar to Parkinson's but has distinct tau protein pathology.
|
31327044 |
2019 |
Neurodegenerative Disorders
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Tauopathies are neurodegenerative diseases characterized by aberrant forms of tau protein accumulation leading to neuronal death in focal brain areas.
|
30907729 |
2019 |
Neurodegenerative Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our cross-sectional and longitudinal data showed a potential clinical utility for DTI to track neurodegenerative disease progression for MAPT mutation carriers in clinical trials.
|
31585367 |
2019 |
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
However, tau protein aggregation has emerged as a potential unifying factor across several neurodegenerative diseases, which has prompted a rapid growth in tau-related funding.
|
30314799 |
2019 |
Neurodegenerative Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Progressive supranuclear palsy is a rare neurodegenerative disease associated with dysfunctional tau protein.
|
31122495 |
2019 |
Neurodegenerative Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Mutations in the MAPT gene, which encodes the tau protein, are associated with several neurodegenerative diseases, including frontotemporal dementia (FTD), dementia with epilepsy, and other types of dementia.
|
30696811 |
2019 |
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Pathologically altered tau protein is a common denominator of neurodegenerative disorders including Alzheimer's disease (AD) and other tauopathies.
|
31391090 |
2019 |
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Alzheimer's disease (AD) is a progressive neurodegenerative disease that was histopathologically characterized in the brain by the presence of extracellular senile plaques made of amyloid β peptides and intracellular neurofibrillary tangles composed of hyperphosphorylated Tau protein.
|
31169189 |
2019 |
Neurodegenerative Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Pathological accumulation of tau protein in brain cells is the hallmark of a group of neurodegenerative diseases called tauopathies.
|
31152932 |
2019 |