MAT2A, methionine adenosyltransferase 2A, 4144

N. diseases: 81; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Familial thoracic aortic aneurysm and aortic dissection
0.600 GeneticVariation disease ORPHANET MAT2A mutations predispose individuals to thoracic aortic aneurysms. 25557781 2015
Familial thoracic aortic aneurysm and aortic dissection
0.600 Biomarker disease CLINGEN MAT2A mutations predispose individuals to thoracic aortic aneurysms. 25557781 2015
Familial thoracic aortic aneurysm and aortic dissection
0.600 Biomarker disease GENOMICS_ENGLAND
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 AlteredExpression disease BEFREE Hepatocellular carcinoma (HCC) is characterized by the down-regulation of the liver-specific methyladenosyltransferase 1A (<i>MAT1A</i>) gene, encoding the S-adenosylmethionine synthesizing isozymes MATI/III, and the up-regulation of the widely expressed methyladenosyltransferase 2A (<i>MAT2A</i>), encoding MATII isozyme, and methyladenosyltransferase 2B (<i>MAT2B</i>), encoding a β-subunit without catalytic action that regulates MATII enzymatic activity. 31073374 2019
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.100 GeneticVariation disease GWASCAT Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies. 30104761 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker disease BEFREE This study aimed to investigate the prognostic implications of the level of histological MAT1A and MAT2A in patients with resected hepatocellular carcinoma (HCC). 29448301 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 AlteredExpression disease BEFREE Thus, the simultaneous downregulation of MAT1A and upregulation of MAT2A are necessary and sufficient for HCC metastasis in the process of M1-M2 switch. 29749642 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker disease BEFREE This review focuses upon the pleiotropic changes, induced by MAT1A/MAT2A switch, associated with HCC development. 23665184 2013
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 AlteredExpression disease BEFREE In hepatocellular carcinoma (HCC), MAT1A downregulation and MAT2A upregulation occur, known as the MAT1A:MAT2A switch. 24098708 2013
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 AlteredExpression disease BEFREE In conclusion, we found for the first time a post-transcriptional regulation of MAT1A and MAT2A by AUF1 and HuR in HCC. 22318685 2012
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 AlteredExpression disease BEFREE Thus, we proposed that HBx activates MAT2A expression through NF-κB and CREB signaling pathways to reduce AdoMet production, inhibit hepatoma cell apoptosis, and perhaps enhance HCC development. 21247894 2011
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 AlteredExpression disease BEFREE Our data strongly support a role for AUF1 and HuR/methyl-HuR in liver de-differentiation, development, and human HCC progression through the posttranslational regulation of MAT1A and MAT2A mRNAs. 20102719 2010
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker disease BEFREE MAT1A is silenced while MAT2A and MAT2beta are induced in hepatocellular carcinoma (HCC). 17154373 2007
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker disease BEFREE In human hepatocellular carcinoma (HCC) MAT1A is replaced by MAT2A. 16054984 2005
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 AlteredExpression disease LHGDN Methionine adenosyltransferase II alpha2 and beta subunit expression was analyzed in human and rat liver and hepatoma cell lines and their interaction studied in HuH7 cells. beta Subunit expression was up- and down-regulated in human hepatoma cell lines and the effect on DNA synthesis determined. 12671891 2003
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 AlteredExpression disease BEFREE L-methionine availability regulates expression of the methionine adenosyltransferase 2A gene in human hepatocarcinoma cells: role of S-adenosylmethionine. 12660248 2003
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 PosttranslationalModification disease BEFREE We found nuclear binding of NF-kappa B and AP-1 to the MAT2A promoter increased in HCC. 14530285 2003
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 AlteredExpression disease BEFREE Methionine adenosyltransferase II alpha2 and beta subunit expression was analyzed in human and rat liver and hepatoma cell lines and their interaction studied in HuH7 cells. beta Subunit expression was up- and down-regulated in human hepatoma cell lines and the effect on DNA synthesis determined. 12671891 2003
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 AlteredExpression disease BEFREE The purpose of the present study was to better understand the molecular mechanism of increased MAT2A expression in HCC. 11427482 2001
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker disease BEFREE We found that the human MAT2A promoter is hypomethylated in hepatocellular carcinoma, in which the gene is upregulated transcriptionally, but hypermethylated in normal liver, in which the gene is minimally expressed. 11208539 2001
CUI: C0003504
Disease: Aortic Valve Insufficiency
Aortic Valve Insufficiency
0.100 Biomarker disease HPO
CUI: C0003706
Disease: Arachnodactyly
Arachnodactyly
0.100 Biomarker disease HPO
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.100 Biomarker disease HPO
CUI: C0008031
Disease: Chest Pain
Chest Pain
0.100 Biomarker phenotype HPO
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.100 Biomarker disease HPO