Familial thoracic aortic aneurysm and aortic dissection
|
0.600 |
GeneticVariation
|
disease |
ORPHANET |
MAT2A mutations predispose individuals to thoracic aortic aneurysms.
|
25557781 |
2015 |
Familial thoracic aortic aneurysm and aortic dissection
|
0.600 |
Biomarker
|
disease |
CLINGEN |
MAT2A mutations predispose individuals to thoracic aortic aneurysms.
|
25557781 |
2015 |
Familial thoracic aortic aneurysm and aortic dissection
|
0.600 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Hepatocellular carcinoma (HCC) is characterized by the down-regulation of the liver-specific methyladenosyltransferase 1A (<i>MAT1A</i>) gene, encoding the S-adenosylmethionine synthesizing isozymes MATI/III, and the up-regulation of the widely expressed methyladenosyltransferase 2A (<i>MAT2A</i>), encoding MATII isozyme, and methyladenosyltransferase 2B (<i>MAT2B</i>), encoding a β-subunit without catalytic action that regulates MATII enzymatic activity.
|
31073374 |
2019 |
Coronary Artery Disease
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies.
|
30104761 |
2018 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study aimed to investigate the prognostic implications of the level of histological MAT1A and MAT2A in patients with resected hepatocellular carcinoma (HCC).
|
29448301 |
2018 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thus, the simultaneous downregulation of MAT1A and upregulation of MAT2A are necessary and sufficient for HCC metastasis in the process of M1-M2 switch.
|
29749642 |
2018 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This review focuses upon the pleiotropic changes, induced by MAT1A/MAT2A switch, associated with HCC development.
|
23665184 |
2013 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In hepatocellular carcinoma (HCC), MAT1A downregulation and MAT2A upregulation occur, known as the MAT1A:MAT2A switch.
|
24098708 |
2013 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, we found for the first time a post-transcriptional regulation of MAT1A and MAT2A by AUF1 and HuR in HCC.
|
22318685 |
2012 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thus, we proposed that HBx activates MAT2A expression through NF-κB and CREB signaling pathways to reduce AdoMet production, inhibit hepatoma cell apoptosis, and perhaps enhance HCC development.
|
21247894 |
2011 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our data strongly support a role for AUF1 and HuR/methyl-HuR in liver de-differentiation, development, and human HCC progression through the posttranslational regulation of MAT1A and MAT2A mRNAs.
|
20102719 |
2010 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MAT1A is silenced while MAT2A and MAT2beta are induced in hepatocellular carcinoma (HCC).
|
17154373 |
2007 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In human hepatocellular carcinoma (HCC) MAT1A is replaced by MAT2A.
|
16054984 |
2005 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Methionine adenosyltransferase II alpha2 and beta subunit expression was analyzed in human and rat liver and hepatoma cell lines and their interaction studied in HuH7 cells. beta Subunit expression was up- and down-regulated in human hepatoma cell lines and the effect on DNA synthesis determined.
|
12671891 |
2003 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
L-methionine availability regulates expression of the methionine adenosyltransferase 2A gene in human hepatocarcinoma cells: role of S-adenosylmethionine.
|
12660248 |
2003 |
Liver carcinoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
We found nuclear binding of NF-kappa B and AP-1 to the MAT2A promoter increased in HCC.
|
14530285 |
2003 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Methionine adenosyltransferase II alpha2 and beta subunit expression was analyzed in human and rat liver and hepatoma cell lines and their interaction studied in HuH7 cells. beta Subunit expression was up- and down-regulated in human hepatoma cell lines and the effect on DNA synthesis determined.
|
12671891 |
2003 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The purpose of the present study was to better understand the molecular mechanism of increased MAT2A expression in HCC.
|
11427482 |
2001 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We found that the human MAT2A promoter is hypomethylated in hepatocellular carcinoma, in which the gene is upregulated transcriptionally, but hypermethylated in normal liver, in which the gene is minimally expressed.
|
11208539 |
2001 |
Aortic Valve Insufficiency
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Arachnodactyly
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Transient Ischemic Attack
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Chest Pain
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Coronary Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|