Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE Long non-coding RNA ENST00462717 suppresses the proliferation, survival, and migration by inhibiting MDM2/MAPK pathway in glioma. 28189682 2017
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE It confers glioma cell sensitivity to teniposide through binding to the 3'-UTR region of MDM2 leading to its reduced expression. 25151861 2015
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE Surprisingly, gliomas that develop in GFAP-HRas(V12);p53(+/KI) mice abrogate the p53 pathway by mutating p19(ARF)/MDM2 while retaining wild-type p53 allele. 23542378 2013
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE The polyarginine11R as a PTD, nuclear localization sequence (NLS), and laminin (Ln) fused to the p53 peptide corresponding to the MDM2 binding site (p53-NLS-Ln-11R) effectively penetrated the plasma membrane of the glioma cells and was translocated into the nucleus. 22528789 2012
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE Together, our findings suggest that p48 functions as an oncogene by promoting glioma tumorigenicity via interactions with HDM2 that contribute to p53 downregulation. 21098709 2011
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation disease BEFREE Resistance to genotoxic modalities in p53-positive gliomas is generally attributed to attenuation of p53 functions by mutations of other components within the p53 signaling axis, such as p14(Arf), MDM2, and ATM, but this explanation is not entirely satisfactory. 21397859 2011
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE The prime importance of p53 signaling for gliomapathogenesis is further evidenced by epistatic genetic events targeting additional pathway components including deletion of p14 (Arf) (CDKN2A) and amplification of the p53-degrading ubiquitin ligases MDM2 and MDM4.  Recent studies have identified and validated Bcl2-Like 12 (Bcl2L12) as a potent glioma oncoprotein with multiple strategic points in apoptosis regulatory networks, i.e. effector caspases and the p53 tumor suppressor. 21200141 2011
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation disease BEFREE Further genetic screening of 284 low- and high-grade gliomas revealed that HDMX amplifications occur solely in pediatric and adult GBMs and that they are mutually exclusive of TP53 mutations and MDM2 amplifications. 20472715 2010
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression disease BEFREE Reactivation of p53 by either gene transfer or pharmacologic approaches may compensate for loss of p19Arf or excess mdm2 expression, common events in melanoma and glioma. 20569441 2010
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression disease LHGDN study showed that MDM2 amplification and overexpression might be an early event in the growth of human gliomas 16696307 2007
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation disease BEFREE The MDM2 Ex12+162A>G variant was associated with significantly reduced risk of glioma. 17684142 2007
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression disease BEFREE The hdm-2 oncogene is overexpressed in several types of malignancies including osteosarcomas, soft tissue sarcomas and gliomas and hdm-2 has been associated with accelerated tumor formation in both hereditary and sporadic cancers. 16732328 2006
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease LHGDN MDM2 may have implications for glioma cell death susceptibility 15771712 2005
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE The mutant proteins were effectively delivered in glioma cells and were resistant to Mdm2-mediated ubiquitination. 15996664 2005
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease LHGDN Mdm2 in female patients is an independent prognostic factor, associated with shorter survival in brain glioma. 15218947 2004
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression disease BEFREE The expression of p73, p21 and MDM2 proteins in gliomas. 12241107 2003
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation disease BEFREE In this study, we examined the effect of flavopiridol on a panel of glioma cell lines having different genetic profiles: five of six have codeletion of p16(INK4a) and p14(ARF); three of six have p53 mutations; and one of six shows overexpression of mouse double minute-2 (MDM2) protein. 12589031 2003
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE It has been shown that the Hdmx gene is amplified in a subset of gliomas, but thus far, no data are available on HDMX protein expression in tumor cells. 11280734 2001
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation disease BEFREE The early growth response gene EGR-1 behaves as a suppressor gene that is down-regulated independent of ARF/Mdm2 but not p53 alterations in fresh human gliomas. 11555594 2001
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE Differential p53, p21, mdm2 and Rb regulation in glioma cell lines that overexpress wild-type p53. 9664113 1998
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE Reliability of differential PCR for the detection of EGFR and MDM2 gene amplification in DNA extracted from FFPE glioma tissue. 7815080 1995
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression disease BEFREE Analysis of glioma cell lines for amplification and overexpression of MDM2. 7529554 1995
CUI: C0017638
Disease: Glioma
Glioma
0.400 GenomicAlterations disease CGI