Autistic Disorder
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Our findings suggest that MECP2 overexpression can cause the auditory cortex to have atypical response properties, an implication that could be helpful for further understanding the nature of auditory deficits in autism.
|
31133783 |
2019 |
Autistic Disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Alterations in MECP2 levels have also been identified in patients with autism.
|
29698767 |
2019 |
Autistic Disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
One such gene is methyl-CpG-binding protein 2 (MECP2), which has been most prominently associated with the neurodevelopmental disorder Rett syndrome, as well as major neuropsychiatric disorders such as autism and schizophrenia.
|
31273722 |
2019 |
Autistic Disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
© 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Altered expressions of the methyl-CpG-binding protein 2 (MECP2) gene are usually associated with neurodevelopmental disorders, such as autism spectrum disorders, Rett syndrome (RTT), and so forth.
|
31389199 |
2019 |
Autistic Disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
The methyl-CpG-binding protein 2 (MECP2) gene has been implicated in multiple neuropsychiatric disorders such as autism and schizophrenia and, most notably, Rett syndrome (RTT).
|
31273723 |
2019 |
Autistic Disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
Whether adult neurogenesis may play a role in pathogenesis of autism and the role of MECP2 on state determination of adult neural stem cells (NSCs) remain largely unclear.
|
28139724 |
2017 |
Autistic Disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
MECP2 gene duplication in human causes neuropsychiatric symptoms such as mental retardation and autism.
|
28743991 |
2017 |
Autistic Disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
Dysfunctions of MeCP2 protein lead to various neurological disorders such as Rett syndrome and Autism.
|
27064487 |
2016 |
Autistic Disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Reciprocal regulation of autism-related genes MeCP2 and PTEN via microRNAs.
|
26843422 |
2016 |
Autistic Disorder
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2.
|
26808898 |
2016 |
Autistic Disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
Does MeCP2 deficiency in autism confer protection against later development of Alzheimer's disease? A reply to Oberman and Pascual-Leone (2014).
|
27241247 |
2016 |
Autistic Disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Disruption of the MECP2 gene leads to Rett syndrome (RTT), a severe neurological disorder with features of autism.
|
25762136 |
2015 |
Autistic Disorder
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Elevated 5-hydroxymethylcytosine in the Engrailed-2 (EN-2) promoter is associated with increased gene expression and decreased MeCP2 binding in autism cerebellum.
|
25290267 |
2014 |
Autistic Disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
This phylogenetic analysis has provided some interesting and valuable insights into the regulation of the MECP2 gene involved in autism.
|
24040966 |
2013 |
Autistic Disorder
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Transcriptional regulation of the MET receptor tyrosine kinase gene by MeCP2 and sex-specific expression in autism and Rett syndrome.
|
24150225 |
2013 |
Autistic Disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
Briefly, sequencing of exons 1 to 4 of MECP2 is recommended for patients with a Rett syndrome phenotype, unexplained neonatal encephalopathy, an Angelman syndrome phenotype (with negative 15q11-13 analysis), nonspecific mental retardation, or autism (females).
|
22123427 |
2012 |
Autistic Disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
Based on the published literature, MECP2 is the most autism-associated gene among the identified CNVs.
|
22909152 |
2012 |
Autistic Disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
The expanding role of MBD genes in autism: identification of a MECP2 duplication and novel alterations in MBD5, MBD6, and SETDB1.
|
23055267 |
2012 |
Autistic Disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This review explores the commonalities and differences between autism and RTT at clinical and molecular levels with respect to current status and challenges for each, highlights recent findings from the Rare Disease Network Natural History study on RTT, and summarizes the broad range of phenotypes resulting from mutations in the methyl-CpG-binding protein 2 gene (MECP2), which is responsible for RTT in 95% of individuals with the disorder.
|
21825235 |
2011 |
Autistic Disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
MECP2 mutations were also identified in patients with autism without RTT.
|
21600714 |
2011 |
Autistic Disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We review recent progress in this area, focusing on two examples of mouse models of autism spectrum disorders (ASDs): Mecp2 models of Rett syndrome, and a Met-knockout model of non-syndromic forms of autism.
|
21733672 |
2011 |
Autistic Disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Rett syndrome (RTT) is an autism spectrum developmental disorder caused by mutations in the X-linked methyl-CpG binding protein 2 (MECP2) gene.
|
21966470 |
2011 |
Autistic Disorder
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Altered expression of several autism candidate genes such as FMR-1 and MECP2, could be detected in leukocytes.
|
21935445 |
2011 |
Autistic Disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Replication of studies in a large-sized sample and a well-characterized subgroup of autism are warranted to further identify the association of MECP2 gene duplication with autism.
|
21531908 |
2011 |
Autistic Disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Misregulation of the methyl-CpG-binding protein 2 (MECP2) gene has been found to cause a myriad of neurological disorders including autism, mental retardation, seizures, learning disabilities, and Rett syndrome.
|
19921286 |
2010 |