|
Squamous cell carcinoma of the head and neck
|
0.390 |
PosttranslationalModification
|
disease |
BEFREE |
The current study aimed to examine the association between head and neck squamous cell carcinoma (HNSCC) and infection with different human papillomavirus virus (HPV) subtypes, including analysis of promoter methylation of several genes (APC, CDKN2A, MGMT, CDH1 and TIMP3) and the correlation with their mRNA expression in tumours and surgical margins.
|
30624179 |
2019 |
|
Squamous cell carcinoma of the head and neck
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
We detected frequent methylation of p16 (44%), RASSF1A (18%), E-cadherin (53%), H-cadherin (35%), MGMT (35%), DAPK (53%), DCC (42%), COL1A2 (44%), TAC1 (61%), SST (64%), and GALR1 (44%) in HNSCC.
|
27027429 |
2016 |
|
Squamous cell carcinoma of the head and neck
|
0.390 |
Biomarker
|
disease |
CTD_human |
Promoter region hypermethylation and mRNA expression of MGMT and p16 genes in tissue and blood samples of human premalignant oral lesions and oral squamous cell carcinoma.
|
24991542 |
2014 |
|
Squamous cell carcinoma of the head and neck
|
0.390 |
Biomarker
|
disease |
BEFREE |
To validate a panel of methylation-based salivary rinse biomarkers (P16, CCNA1, DCC, TIMP3, MGMT, DAPK, and MINT31) previously shown to be independently associated with poor overall survival and local recurrence in a larger, separate cohort of patients with head and neck squamous cell carcinoma (HNSCC).
|
22228635 |
2012 |
|
Squamous cell carcinoma of the head and neck
|
0.390 |
PosttranslationalModification
|
disease |
BEFREE |
Here, using the MSP procedure, we evaluated the frequency of hypermethylation of RARbeta, RASSF1A, HIN-1, GSTP1, MGMT, VHL and DAPK genes in several laryngeal and other head and neck squamous cell carcinoma cell lines and the effect of various polyphenols on the methylation of RARbeta and MGMT genes in the UT-SCC 42B cell line.
|
21078381 |
2011 |
|
Squamous cell carcinoma of the head and neck
|
0.390 |
Biomarker
|
disease |
BEFREE |
a) MGMT was lower in NM than in PBLCs. b) Smoking reduced MGMT in NM but had no effect in PBLCs. c) MGMT activity increased in the sequence NM<SIN II and III<CIS. d) There was no correlation between MGMT and prognostic parameters or clinical course in SCCHN.
|
20682983 |
2010 |
|
Squamous cell carcinoma of the head and neck
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our results suggest that any one of MGMT variants may not have a substantial effect on SCCHN risk, but a joint effect of several MGMT variants may contribute to risk and progression of SCCHN, particularly for oropharyngeal cancer, in non-Hispanic whites.
|
20206583 |
2010 |
|
Squamous cell carcinoma of the head and neck
|
0.390 |
Biomarker
|
disease |
BEFREE |
As many of these evaluations are obscured by a heterogeneity of treatments, the current study aimed to evaluate the incidence and prognostic value of the promoter hypermethylation of TIMP3, CDH1, DAPK, RASSF1A, p16INK4A and MGMT in HNSCC treated solely by radiotherapy.
|
19148529 |
2009 |
|
Squamous cell carcinoma of the head and neck
|
0.390 |
PosttranslationalModification
|
disease |
BEFREE |
MGMT promoter hypermethylation and apparent loss of protein expression are reliable and independent prognostic factors in HNSCC.
|
15184253 |
2004 |
|
Squamous cell carcinoma of the head and neck
|
0.390 |
Biomarker
|
disease |
BEFREE |
Methylation of p16, RARbeta, and MGMT may constitute early events in HNSC tumorigenesis.
|
15173091 |
2004 |