MLH1, mutL homolog 1, 4292

N. diseases: 526; N. variants: 757
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.490 GeneticVariation group BEFREE Exposure to IR accelerated T-cell lymphoma induction in the Mlh1-/- mice, and whole-exome sequencing revealed that IR exposure neither increased the number of mutations nor altered the mutation spectrum of the lymphomas. 30721949 2019
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.490 Biomarker group BEFREE In addition, whole-exome sequencing analysis revealed high SNVs and INDELs in lymphomas being driven by loss of Mlh1 and frequently mutated genes had a strong correlation with human leukemias. 30275527 2019
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.490 GeneticVariation group BEFREE Notably, loss of the DNA repair gene Mlh1 caused lymphoma in a wild-type background, and its enforced expression was able to delay tumor development driven by loss of p53. 29892060 2018
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.490 Biomarker group CTD_human However, the Mlh1-deficient mice treated with DES tended to become moribund at an early age and had very early onset of lymphoma. 15700306 2005
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.490 Biomarker group BEFREE Twenty-five primary tumours and 105 serial biopsies taken at various time points after treatment were examined using a methylation-specific polymerase chain reaction (MSP) for a panel of genes, comprising p73, p16, hMLH1, RARbeta and p15, previously shown to be methylated in NK cell lymphomas. 12823347 2003
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.490 AlteredExpression group LHGDN The hMSH2 transcript was present in all cases of lymphoma, while the expression of hMLH1 and hPMS1 was significantly low in some large B-cell lymphomas (four and five out of 14 cases, respectively) and in mantle cell lymphomas of the blastoid type (two out of two cases). 11999575 2002
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.490 GeneticVariation group BEFREE Café-au-lait spots with early onset colorectal neoplasia may identify families with a variant of HNPCC characterized by oligopolyposis, glioblastoma at young age, and lymphoma. 14574005 2001
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.490 Biomarker group BEFREE The role of DNA mismatch repair proteins (hMSH2 and hMLH1) and p21(waf1) in pediatric tumor responses to chemotherapy and irradiation is described in the present study of 23 pediatric solid cancers (4 wilms' tumors, 9 neuroblastomas, 3 hepatoblastomas, 3 lymphomas and 4 sarcomas) using immunohistochemical methods. 11496300 2001
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.490 Biomarker group BEFREE To clarify this relationship, we searched for hMLH1 expression and mismatch repair deficiency in the duodenal lymphoma. hMLH1 immunostaining was positive in lymphoid tumor cells, and no microsatellite instability was detected. 10824932 2000
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.490 Biomarker group BEFREE To investigate disruptions of the mismatch repair system in hematological malignancies, we examined alterations of the human mutL homologue 1 (hMLH1) gene, a member of the mismatch repair gene family, in a total of 43 human leukemia and lymphoma cell lines, by polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP) and sequencing analyses. 9057658 1997
CUI: C0024299
Disease: Lymphoma
Lymphoma
0.490 Biomarker group HPO