Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE We used karyotyping, fluorescence in situ hybridization (FISH), Southern blotting, and RT-PCR in order to analyze prospectively 77 infants (less than 1 year of age) with acute lymphoblastic leukemia for the occurrence of 11q23/MLL rearrangements and/or other cytogenetic abnormalities. 12200682 2002
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE A case of infantile acute lymphoblastic leukemia presenting with rearrangement of MLL at 11q23 and apparent insertion or translocation at 10p12. 15381373 2004
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease LHGDN Reassessment of loss of heterozygosity within MLL in childhood acute lymphoblastic leukemia. 12732503 2003
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE We used a new approach called panhandle polymerase chain reaction (PCR) to clone an MLL genomic translocation breakpoint in a case of acute lymphoblastic leukemia of infancy in which karyotype analysis was technically unsuccessful and did not show the translocation partner. 9389682 1997
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE Clinical features and outcome of MLL gene rearranged acute lymphoblastic leukemia in infants with additional chromosomal abnormalities other than 11q23 translocation. 18448165 2008
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE Frequency and prognostic significance of t(v;11q23)/KMT2A rearrangements in adult patients with acute lymphoblastic leukemia treated with risk-adapted protocols. 27122129 2017
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE AF4 is the 4q21 gene involved in the acute lymphoblastic leukemia associated t(4;11)(q21;q23) where it forms a fusion gene with MLL. 9365243 1997
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE Acute lymphoblastic leukemia in infants (< 1 year-of-age) is characterized by a high incidence of MLL rearrangements. 24736461 2014
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE Near-precise interchromosomal recombination and functional DNA topoisomerase II cleavage sites at MLL and AF-4 genomic breakpoints in treatment-related acute lymphoblastic leukemia with t(4;11) translocation. 11493704 2001
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE The clinical characteristics, therapy and outcome of 85 adults with acute lymphoblastic leukemia and t(4;11)(q21;q23)/MLL-AFF1 prospectively treated in the UKALLXII/ECOG2993 trial. 23349309 2013
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE The precise incidence of MLL gene rearrangement in S-ALL still remains to be clarified. 9168451 1997
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE The human AF9/MLLT3 gene is a common fusion partner for the MLL gene in translocations t(9;11)(p22;q23) associated with acute myeloid leukemia and acute lymphocytic leukemia. 16001262 2005
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE A partial nontandem duplication (PNTD) of mixed lineage leukemia (MLL) gene is described in B-cell acute lymphoid leukemia without structural cytogenetic abnormalities at 11q23 and 9p22. 11196198 2001
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE Fms-like tyrosine kinase 3 (FLT3) is highly expressed in acute lymphoblastic leukemia with the mixed-lineage leukemia (MLL) gene rearrangement refractory to chemotherapy. 17942916 2007
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE Analysis of the role of hematopoietic stem-cell transplantation in infants with acute lymphoblastic leukemia in first remission and MLL gene rearrangements: a report from the Children's Oncology Group. 21135279 2011
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE MLL rearrangements are translocation mutations that cause both acute lymphoblastic leukemia and acute myeloid leukemia (AML). 31405949 2019
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE MLL gene rearrangement is a new subgroup concerned with prognosis in T-ALL/LBL. 22710816 2012
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE Here, we describe a pediatric B-LBL patient who presented with extensive abdominal involvement and whose lymphoma cells displayed segmental duplication of the mixed lineage leukemia (MLL) gene. 22052166 2012
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE Considering morphological types, 24/38 cases with acute lymphoblastic leukemia and 5/7 patients with acute myeloid leukemia showed ALL-1 rearrangements. 7885037 1995
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE Reciprocal chromosomal translocations involving the MLL gene at chromosome region 11q23 are recurring cytogenetic abnormalities in both de novo and therapy-related acute myeloid leukemia (AML) and in acute lymphoblastic leukemia. 17854671 2007
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease LHGDN Acute lymphoblastic leukemia in a patient with chronic granulomatous disease and a novel mutation in CYBB: first report. 16138344 2005
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE We demonstrate that unique or clonotypic MLL-AF4 genomic fusion sequences are present and detectable in neonatal blood spots from individuals who were diagnosed with acute lymphoblastic leukemia at ages 5 months to 2 years and, therefore, have arisen during fetal hematopoiesis in utero. 9391133 1997
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE Chemosensitivity is differentially regulated by the SDF-1/CXCR4 and SDF-1/CXCR7 axes in acute lymphoblastic leukemia with MLL gene rearrangements. 30453100 2018
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE We present a case of an infant with bilateral ovarian B-lineage lymphoblastic lymphoma with MLL gene rearrangement. 25493458 2015
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE In this case study, we diagnosed t-MN with KMT2A rearrangement in a patient with history of B-ALL with 9p deletion and gain of X chromosome. 29155023 2017