Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE Here, we describe a pediatric B-LBL patient who presented with extensive abdominal involvement and whose lymphoma cells displayed segmental duplication of the mixed lineage leukemia (MLL) gene. 22052166 2012
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE T-cell lymphoblastic leukemia in early childhood presents NOTCH1 mutations and MLL rearrangements. 19631984 2010
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE MLL rearrangements in humans lead to both acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL). 18538728 2008
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE In acute lymphoblastic leukemia, besides age and white cell count at diagnosis, the cytogenetic abnormalities t(9;22)/BCR-ABL and t(4;11)/MLL-AF4 are important prognostic markers and are often included in the treatment stratification of patients with adult acute lymphoblastic leukemia. 18728022 2008
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE Reciprocal chromosomal translocations involving the MLL gene at chromosome region 11q23 are recurring cytogenetic abnormalities in both de novo and therapy-related acute myeloid leukemia (AML) and in acute lymphoblastic leukemia. 17854671 2007
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE We characterize at both the DNA and RNA level a rare MLL-AF4 fusion transcript identified in a 15-month-old girl with acute lymphoblastic leukemia. 17889710 2007
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE The distribution of MLL breakpoints for clinical subtypes (acute lymphoblastic leukemia, acute myeloid leukemia, pediatric and adult) and fused translocation partner genes (TPGs) will be presented, including novel MLL fusion genes. 19262598 2009
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE The clinical characteristics, therapy and outcome of 85 adults with acute lymphoblastic leukemia and t(4;11)(q21;q23)/MLL-AFF1 prospectively treated in the UKALLXII/ECOG2993 trial. 23349309 2013
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE Analysis of the role of hematopoietic stem-cell transplantation in infants with acute lymphoblastic leukemia in first remission and MLL gene rearrangements: a report from the Children's Oncology Group. 21135279 2011
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE Recently, it was shown that inactivation of the TP53 tumor suppressor gene occurs frequently in cases of acute lymphoblastic leukemia carrying MLL rearrangements. 8824725 1996
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE Therapy-related B-lymphoblastic leukemia associated with Philadelphia chromosome and MLL rearrangement: Single institution experience and the review of the literature. 26259760 2016
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE We found four AML cell lines with an MLL PTD; one acute lymphoblastic leukemia-derived cell line was reported to show a partial nontandem duplication. 14671638 2004
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE A partial nontandem duplication (PNTD) of mixed lineage leukemia (MLL) gene is described in B-cell acute lymphoid leukemia without structural cytogenetic abnormalities at 11q23 and 9p22. 11196198 2001
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE Fms-like tyrosine kinase 3 (FLT3) is highly expressed in acute lymphoblastic leukemia with the mixed-lineage leukemia (MLL) gene rearrangement refractory to chemotherapy. 17942916 2007
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE We demonstrate that unique or clonotypic MLL-AF4 genomic fusion sequences are present and detectable in neonatal blood spots from individuals who were diagnosed with acute lymphoblastic leukemia at ages 5 months to 2 years and, therefore, have arisen during fetal hematopoiesis in utero. 9391133 1998
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE A case of infantile acute lymphoblastic leukemia presenting with rearrangement of MLL at 11q23 and apparent insertion or translocation at 10p12. 15381373 2004
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE Therapy-related B lymphoblastic leukemia with t(4;11)(q21;q23)/AF4-MLL in a patient with mantle cell lymphoma after recent aggressive chemotherapy: a unique case report. 24817983 2015
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE Outcome of recurrent or refractory acute lymphoblastic leukemia in infants with MLL gene rearrangements: A report from the Japan Infant Leukemia Study Group. 19229974 2009
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE This hypothesis was confirmed by the detection of deletions of the 3' regions of the CBFB and the MLL genes in AML M4 patients with inv(16) and in patients with ALL and AML associated with MLL gene translocations, respectively. 11369654 2001
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease LHGDN MLL-AF4 fusion gene rearrangements occurs between chromosome 4 and 11 in pre B-cell lymphoblastic leukemia 11943339 2002
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE Therapy-related acute lymphoblastic leukemia with MLL rearrangement following treatment of Burkitt's leukemia. 16019540 2008
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE Acute lymphoblastic leukemia in infants (< 1 year-of-age) is characterized by a high incidence of MLL rearrangements. 24736461 2015
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE Prognostic significance of FLT3 mutational status and expression levels in MLL-AF4+ and MLL-germline acute lymphoblastic leukemia. 22705992 2013
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE MLL gene rearrangement is a new subgroup concerned with prognosis in T-ALL/LBL. 22710816 2012
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE Although FLT3 mutations are essentially found in myeloid-lineage leukemia cells, a high level of FLT3 expression was recently observed in MLL gene-rearranged acute lymphoblastic leukemia without FLT3 mutations. 14604973 2004