Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE We used karyotyping, fluorescence in situ hybridization (FISH), Southern blotting, and RT-PCR in order to analyze prospectively 77 infants (less than 1 year of age) with acute lymphoblastic leukemia for the occurrence of 11q23/MLL rearrangements and/or other cytogenetic abnormalities. 12200682 2002
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE A case of infantile acute lymphoblastic leukemia presenting with rearrangement of MLL at 11q23 and apparent insertion or translocation at 10p12. 15381373 2004
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 Biomarker disease CTD_human Acute lymphoblastic leukemia in infants (< 1 year-of-age) is characterized by a high incidence of MLL rearrangements. 24736461 2014
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 Biomarker disease BEFREE We report two cases of AML (M5a and M0) and one case of acute lymphoblastic leukemia containing MLL-AF10 fusion. 11187895 2000
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease LHGDN Reassessment of loss of heterozygosity within MLL in childhood acute lymphoblastic leukemia. 12732503 2003
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE We used a new approach called panhandle polymerase chain reaction (PCR) to clone an MLL genomic translocation breakpoint in a case of acute lymphoblastic leukemia of infancy in which karyotype analysis was technically unsuccessful and did not show the translocation partner. 9389682 1997
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 AlteredExpression disease LHGDN The incidence of T-cell receptor gene rearrangements in childhood B-lineage acute lymphoblastic leukemia is related to immunophenotype and fusion oncogene expression. 16386788 2006
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE Clinical features and outcome of MLL gene rearranged acute lymphoblastic leukemia in infants with additional chromosomal abnormalities other than 11q23 translocation. 18448165 2008
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE Frequency and prognostic significance of t(v;11q23)/KMT2A rearrangements in adult patients with acute lymphoblastic leukemia treated with risk-adapted protocols. 27122129 2017
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 Biomarker disease BEFREE MLL-AF4 acute lymphocytic leukemia exhibits both myeloid and B-cell surface markers, suggesting that the transformed cells are B-cell myeloid progenitor cells. 23893300 2013
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE AF4 is the 4q21 gene involved in the acute lymphoblastic leukemia associated t(4;11)(q21;q23) where it forms a fusion gene with MLL. 9365243 1997
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE Acute lymphoblastic leukemia in infants (< 1 year-of-age) is characterized by a high incidence of MLL rearrangements. 24736461 2014
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 Biomarker disease BEFREE Two consecutive immunophenotypic switches in a child with MLL-rearranged acute lymphoblastic leukemia. 16709517 2006
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE Near-precise interchromosomal recombination and functional DNA topoisomerase II cleavage sites at MLL and AF-4 genomic breakpoints in treatment-related acute lymphoblastic leukemia with t(4;11) translocation. 11493704 2001
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE The clinical characteristics, therapy and outcome of 85 adults with acute lymphoblastic leukemia and t(4;11)(q21;q23)/MLL-AFF1 prospectively treated in the UKALLXII/ECOG2993 trial. 23349309 2013
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 Biomarker disease BEFREE Moreover, aberrant down-regulation of let-7b (~70-fold) in MLL-rearranged acute lymphoblastic leukemia was linked to up-regulation of oncoprotein c-Myc (P(FDR)<0.0001). 21242186 2011
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE The precise incidence of MLL gene rearrangement in S-ALL still remains to be clarified. 9168451 1997
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 Biomarker disease BEFREE 11q23 translocations (t(11q23)) are recurring cytogenetic abnormalities in both acute myeloid leukemia (AML) and acute lymphoblastic leukemia, involving the same gene, ALL1 (or MLL). 9529125 1998
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 AlteredExpression disease LHGDN Involvement of the MLL gene located at chromosome region 11q23 is a frequent occurrence in both acute myelocytic leukemia and acute lymphoblastic leukemia. 14580777 2003
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 Biomarker disease CTD_human The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias. 25730765 2015
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE The human AF9/MLLT3 gene is a common fusion partner for the MLL gene in translocations t(9;11)(p22;q23) associated with acute myeloid leukemia and acute lymphocytic leukemia. 16001262 2005
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE A partial nontandem duplication (PNTD) of mixed lineage leukemia (MLL) gene is described in B-cell acute lymphoid leukemia without structural cytogenetic abnormalities at 11q23 and 9p22. 11196198 2001
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 Biomarker disease LHGDN [Detection of fusion genes resulting from chromosome abnormalities in childhood acute lymphoblastic leukemia]. 16215946 2005
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE Fms-like tyrosine kinase 3 (FLT3) is highly expressed in acute lymphoblastic leukemia with the mixed-lineage leukemia (MLL) gene rearrangement refractory to chemotherapy. 17942916 2007
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE Analysis of the role of hematopoietic stem-cell transplantation in infants with acute lymphoblastic leukemia in first remission and MLL gene rearrangements: a report from the Children's Oncology Group. 21135279 2011