KMT2A, lysine methyltransferase 2A, 4297

N. diseases: 535; N. variants: 65
Disease: Acute biphenotypic leukemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023464
Disease: Acute biphenotypic leukemia
Acute biphenotypic leukemia 		0.050 Biomarker disease BEFREE The four MLL-related acute leukemia models showed a different course of infant and adult MLL-AF9 acute myeloid leukemia, and a rapid aggressiveness of MLL-ENL acute lymphoblastic leukemia and MLL-AF4 acute biphenotypic leukemia. 22665135 2012
CUI: C0023464
Disease: Acute biphenotypic leukemia
Acute biphenotypic leukemia 		0.050 GeneticVariation disease BEFREE In this work we present the identification of a novel MLL fusion partner in a pediatric patient with de novo biphenotypic acute leukemia. 20920256 2010
CUI: C0023464
Disease: Acute biphenotypic leukemia
Acute biphenotypic leukemia 		0.050 Biomarker disease BEFREE The multilineage differentiation potential of these cells was suggested by their immuno-phenotypes and transcriptional programs and confirmed by their ability to induce three pathologically distinct leukemias in mice, including an acute biphenotypic leukemia (ABL) that recapitulates the distinctive hallmark features of many MLL-associated leukemias in humans. 12620410 2003
CUI: C0023464
Disease: Acute biphenotypic leukemia
Acute biphenotypic leukemia 		0.050 GeneticVariation disease BEFREE Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product. 7689231 1993
CUI: C0023464
Disease: Acute biphenotypic leukemia
Acute biphenotypic leukemia 		0.050 Biomarker disease BEFREE The MLL gene (myeloid/lymphoid leukemia) is involved in each of these translocations. 1384682 1992