Myeloid Leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Zinc finger protein X-linked (ZFX) is a key regulator of both embryonic stem cells (ESCs) and hematopoietic stem cells (HSCs), which is required for both Notch intracellular domain (NotchIC)-induced acute T-cell leukemia and MLL-AF9-induced myeloid leukemia in mouse models.
|
27797721 |
2016 |
Myeloid Leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Most cases of infants with acute lymphoblastic (i-ALL) or myeloid leukemia (i-AML) have KMT2A gene rearrangements (KMT2A-r), which disturb its essential role as an epigenetic regulator of hematopoiesis.
|
28476187 |
2016 |
Myeloid Leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the last 20 years, we have witnessed an exponential number of evidences linking the human mixed lineage leukemia-1 (MLL1) gene to several acute and myelogenous leukemias.
|
23175388 |
2013 |
Myeloid Leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Regulation of HOXA9 activity by predominant expression of DACH1 against C/EBPα and GATA-1 in myeloid leukemia with MLL-AF9.
|
22902925 |
2012 |
Myeloid Leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Patients with a t(9;11) translocation (MLL-AF9) develop acute myeloid leukemia (AML), and while in mice the expression of this fusion oncogene also results in the development of myeloid leukemia, it is with long latency.
|
22427200 |
2012 |
Myeloid Leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Several acute lymphoblastic and myelogenous leukemias are correlated with alterations in the human mixed lineage leukemia protein-1 (MLL1) gene.
|
20236310 |
2010 |
Myeloid Leukemia
|
0.400 |
Biomarker
|
disease |
CTD_human |
Modeling the initiation and progression of human acute leukemia in mice.
|
17463288 |
2007 |
Myeloid Leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Rearrangements of the mixed lineage leukemia gene MLL are associated with aggressive lymphoid and myeloid leukemias.
|
17671196 |
2007 |
Myeloid Leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Two cases of acute myeloid leukemia with t(11;17) associated with varying morphology and immunophenotype: rearrangement of the MLL gene and a region proximal to the RARalpha gene.
|
15899392 |
2005 |
Myeloid Leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Reciprocal rearrangements of the MLL gene are among the most common chromosomal abnormalities in both Acute Lymphoblastic and Myeloid Leukemia.
|
15322560 |
2004 |
Myeloid Leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
MLL fusion proteins are oncogenic transcription factors that are associated with aggressive lymphoid and myeloid leukemias.
|
14701735 |
2004 |
Myeloid Leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The human LASP1 gene is fused to MLL in an acute myeloid leukemia with t(11;17)(q23;q21).
|
12527918 |
2003 |
Myeloid Leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Two new translocations involving the 11q23 region map outside the MLL locus in myeloid leukemias.
|
12368154 |
2002 |
Myeloid Leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The cell line U937, which has been used extensively for studies of myeloid differentiation, bears the t(10;11)(p13;q14) translocation which results in a fusion between the MLLT10 (myeloid/lymphoid or mixed-lineage leukemia [trithorax, Drosophila, homolog]; translocated to 10; alias AF10) gene and the Ap-3-like clathrin assembly protein, PICALM (Clathrin assembly lymphoid myeloid leukaemia).
|
11701946 |
2001 |
Myeloid Leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
AF10 has been reported to be re-arranged with genes other than MLL leading to the same phenotype, a myeloid leukaemia.
|
10860745 |
2000 |
Myeloid Leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
MLL amplification in myeloid leukemias: A study of 14 cases with multiple copies of 11q23.
|
10918392 |
2000 |
Myeloid Leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Previously, we cloned several species of MLL/MEN chimeric cDNAs in a patient with myeloid leukemia carrying the t(11;19)(q23;p13.1) translocation.
|
9277049 |
1997 |
Myeloid Leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recently, a gene known as MLL has been identified which is involved in acute lymphoid and myeloid leukemias with rearrangements at 11q23.
|
7967737 |
1994 |
Myeloid Leukemia
|
0.400 |
Biomarker
|
disease |
CTD_human |
Molecular rearrangements of the MLL gene are present in most cases of infant acute myeloid leukemia and are strongly correlated with monocytic or myelomonocytic phenotypes.
|
8282816 |
1994 |