|
Childhood Acute Myeloid Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Enhancing supportive therapy to reduce TRM will further improve treatment outcomes of KMT2A-rearranged pediatric AML.
|
31707119 |
2019 |
|
Childhood Acute Myeloid Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, the prognosis of pediatric acute myeloid leukemia (AML) with KMT2A rearrangements depends on its translocation partners.
|
30869817 |
2019 |
|
Childhood Acute Myeloid Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A case of pediatric acute myeloid leukemia with t(11;16)(q23;q24) leading to a novel KMT2A-USP10 fusion gene.
|
30107050 |
2018 |
|
Childhood Acute Myeloid Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we found that transforming growth factor β (TGFβ) signaling was upregulated in HSCs from bone marrow of mice with MLL-AF9-induced acute myeloid leukemia (AML) because of excessive production of TGFβ1, especially from megakaryocytes, and overactivation of latent TGFβ1 protein.
|
29307605 |
2018 |
|
Childhood Acute Myeloid Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In pediatric acute myeloid leukemia (AML), chromosomal abnormalities leading to a disruption of the lysine methyltransferase 2A (KMT2A) gene in 11q23 are the most frequent rearrangements.
|
28253492 |
2016 |
|
Childhood Acute Myeloid Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In all other patients, Ras pathway mutations, KMT2A and other methyltransferase mutations, FLT3 mutations, and KIT mutations are all relatively common in childhood AML and all are potentially "druggable".
|
26637766 |
2015 |
|
Childhood Acute Myeloid Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Lower miR-29a expression was mainly observed in MLL-rearranged pediatric acute myeloid leukemia, specifically in cases carrying t(10;11) (P < 0.001).
|
21818844 |
2012 |
|
Childhood Acute Myeloid Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Translocations involving the mixed-lineage leukemia (MLL) gene, localized at 11q23, comprise 15 to 20% of all pediatric acute myeloid leukemia (AML) cases.
|
21566656 |
2011 |
|
Childhood Acute Myeloid Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Translocations involving the mixed lineage leukemia (MLL) gene, localized at 11q23, frequently occur in pediatric acute myeloid leukemia (AML).
|
20861917 |
2010 |
|
Childhood Acute Myeloid Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We identified large differences in outcome within 11q23/MLL-rearranged pediatric AML and novel subgroups based on translocation partners that independently predict clinical outcome.
|
19528532 |
2009 |
|
Childhood Acute Myeloid Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We applied our methods to five cancerous gene expression datasets: leukemia (acute lymphoblastic leukemia [ALL] vs. acute myeloid leukemia [AML]), lung cancer, prostate cancer, breast cancer, and leukemia (ALL vs. mixed-lineage leukemia [MLL] vs. AML).
|
19874631 |
2009 |
|
Childhood Acute Myeloid Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The distribution of MLL breakpoints for clinical subtypes (acute lymphoblastic leukemia, acute myeloid leukemia, pediatric and adult) and fused translocation partner genes (TPGs) will be presented, including novel MLL fusion genes.
|
19262598 |
2009 |
|
Childhood Acute Myeloid Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
MLL-AF9 is the most frequent MLL rearrangement in childhood acute myeloid leukemia (AML) and it may be also found in acute lymphoblastic leukemia (ALL) of patients younger than 1-year-old (infants).
|
18000862 |
2008 |
|
Childhood Acute Myeloid Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Pediatric acute myeloid leukemia with NPM1 mutations is characterized by a gene expression profile with dysregulated HOX gene expression distinct from MLL-rearranged leukemias.
|
17597811 |
2007 |
|
Childhood Acute Myeloid Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
This is the first report of an in vivo animal model exhibiting the systemic involvement of childhood AML containing MLL-PTD.
|
17408461 |
2007 |
|
Childhood Acute Myeloid Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present study showed that cDNA panhandle PCR can identify all rare or novel MLL partner genes.MLL-PTD was rare in childhood AML.
|
16341046 |
2006 |
|
Childhood Acute Myeloid Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Fluorescence in situ hybridization (FISH) was performed in two acute leukemias (AL), one acute myeloid leukemia (AML) M5a, and one treatment-related-AL (t-AL), to investigate the nature of complex changes accompanying the respective t(9;11)(p22;q23)-MLL/AF9 and t(11;16)(q23;p13.3)-MLL/CBP.
|
15075073 |
2004 |
|
Childhood Acute Myeloid Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
X chromosome insertion in the MLL gene in a case of childhood acute myeloblastic leukemia.
|
15262436 |
2004 |
|
Childhood Acute Myeloid Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
FLT3 is expressed and activated in many human leukemias, including a significant percentage of pediatric AML and infant and childhood ALL, especially in the setting of MLL gene rearrangement.
|
15010072 |
2004 |
|
Childhood Acute Myeloid Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Elevated expression of the AF1q gene, an MLL fusion partner, is an independent adverse prognostic factor in pediatric acute myeloid leukemia.
|
15217837 |
2004 |
|
Childhood Acute Myeloid Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here, we report the identification of an MLL-SEPT6 fusion transcript in an infant with acute myeloid leukemia (AML)-M4.
|
14506700 |
2003 |