|
Trisomy 11
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The amplification was presented as: amplification including only the 5' segment of the MLL gene (1 patient), trisomy 11 (3 patients), partial trisomy 11q (2 patients), isochromosome 11q (1 patient), and multiple amplification of specific regions (3 patients).
|
20471515 |
2010 |
|
Trisomy 11
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
MLL rearrangements are usually evident as overt balanced chromosomal translocations by conventional cytogenetic analysis but up to one-third are cryptic rearrangements and occur in leukemias with del(11)(q23), a normal karyotype, or trisomy 11, the latter two of which sometimes are associated with partial tandem duplications of MLL itself (Proc Natl Acad Sci USA 97:2814-2819, 2000; Proc Natl Acad Sci USA 94:3899-3902, 1997).
|
19277575 |
2009 |
|
Trisomy 11
|
0.100 |
Biomarker
|
disease |
BEFREE |
Concomitant presence of MLL and FLT3 anomalies could be relevant in determining the poor outcome of patients with acute myeloid leukemia with trisomy 11.
|
15710585 |
2005 |
|
Trisomy 11
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In addition to the MLL translocation, FISH detected submicroscopic amplification, partial deletion of the MLL gene and trisomy 11 in 12 patients without cytogenetic evidence.
|
12472570 |
2002 |
|
Trisomy 11
|
0.100 |
Biomarker
|
disease |
BEFREE |
We investigated copy number of MLL in seven patients with trisomy 11 to see if duplication could be assessed by the detection of two separate signals on fluorescence in situ hybridization (FISH).
|
11566351 |
2001 |
|
Trisomy 11
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Performing a one-step RT-PCR with 35 cycles using an exon 9 forward primer and an exon 3 reverse primer partial tandem duplications of the MLL gene were demonstrated in 3/8 (37.5%) patients with trisomy 11.
|
10803509 |
2000 |
|
Trisomy 11
|
0.100 |
Biomarker
|
disease |
BEFREE |
Partial-tandem duplication (PTD) of an internal portion of MLL occurs in some cases of acute myelogenous leukemia (AML) with trisomy 11 or a normal karyotype.
|
9790509 |
1998 |
|
Trisomy 11
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The partial tandem duplication of the ALL1 (MLL) gene is found in patients with AML and trisomy 11 as a sole cytogenetic abnormality and in 11% of patients with AML and normal cytogenetics.
|
9482895 |
1998 |
|
Trisomy 11
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
As recent studies showed that MLL gene duplication in fact occurs more often as a primary mutation in the absence of trisomy 11, it is possible that in our case the MLL gene duplication might be the common underlying mutation.
|
9352791 |
1997 |
|
Trisomy 11
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Of 16 acute myeloid leukemia patients with trisomy 11 and rearrangement of MLL reported, our patient was the youngest in age and the only one with AMoL.
|
9209466 |
1997 |
|
Trisomy 11
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We recently discovered that approximately 90% of adult patients with de novo AML and trisomy 11 (+11) as a sole abnormality and 11% of adult patients with de novo AML and normal cytogenetics carry a molecular rearrangement of the ALL1 (MLL, HRX, or HTRX) gene.
|
9108076 |
1997 |
|
Trisomy 11
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We describe a 72-year-old woman suffering from MDS-derived overt leukemia with trisomy 11 and a tandem duplication of the MLL gene.
|
9136917 |
1997 |
|
Trisomy 11
|
0.100 |
Biomarker
|
disease |
BEFREE |
Unexpectedly, MLL gene rearrangements were observed in two of four cases characterized by trisomy 11 as the sole karyotypic abnormality; however, MLL aberrations were not identified in three cases with trisomy 11 accompanied by other karyotypic anomalies.
|
7794746 |
1995 |
|
Trisomy 11
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We detected molecular rearrangements of the ALL-1 gene in 3 of 4 patients with de novo AML and trisomy 11 as a sole chromosomal abnormality.
|
8275471 |
1994 |
|
Trisomy 11
|
0.100 |
Biomarker
|
disease |
BEFREE |
Rearrangement of the ALL-1 genes in two of the patients with trisomy 11 was shown to result from a direct tandem duplication of a portion of the gene spanning exons 2-6.
|
8044771 |
1994 |
|
Trisomy 11
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To characterize the abnormal ALL-1 genes, we cloned the ALL-1 rearrangements from two patients with trisomy 11.
|
8016145 |
1994 |