Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, based on currently available data, we propose that consolidative HCT post-CART therapy be considered for all HCT-eligible patients and especially for pediatric patients with KMT2A-rearranged B-cell acute lymphoblastic leukemia.
|
30973486 |
2019 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
MLL-rearranged (MLLr) B-ALL (MLLr-B-ALL) has, however, an unfavorable prognosis with common therapy refractoriness and early relapse, and therefore new therapeutic targets are needed for relapsed/refractory MLLr-B-ALL.
|
30635633 |
2019 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The pathogenesis of t(4;11)/KMT2A-AFF1<sup>+</sup> (MLL-AF4<sup>+</sup>) infant B-cell acute lymphoblastic leukemia remains difficult to model, and the pathogenic contribution in cancer of the reciprocal fusions resulting from derivative translocated-chromosomes remains obscure.
|
30679323 |
2019 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings uncover MLL-dependent transcriptional activation of BCL6 as a previously unrecognized requirement of malignant transformation by oncogenic MLL fusions and identified BCL6 as a novel target for the treatment of MLL-rearranged B-ALL.
|
31395741 |
2019 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We present a case of an infant who developed pro-B acute lymphoblastic leukemia with a rare and complex MLL-translocation.
|
30553463 |
2018 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
DNA methylation profiling of pediatric B-cell lymphoblastic leukemia with KMT2A rearrangement identifies hypomethylation at enhancer sites.
|
27786413 |
2017 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Together, our data suggest that IGF2BP3-mediated targeting of oncogenic transcripts may represent a critical pathogenetic mechanism in MLL-rearranged B-ALL and support IGF2BP3 and its cognate RNA-binding partners as potential therapeutic targets in this disease.
|
26974154 |
2016 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Despite the small cohort size, it could be postulated that B lineage ALL with MLL abnormalities and mature phenotype is a distinct entity that differs both from the typical Pro B ALL observed in infants and mature B-ALL with high MYC expression.
|
26857438 |
2016 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The MLL-AF4 (MA4) fusion gene is the genetic hallmark of an aggressive infant pro-B-acute lymphoblastic leukemia (B-ALL).
|
26837759 |
2016 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We treated 7 patients with B-cell acute lymphoblastic leukemia (B-ALL) harboring rearrangement of the mixed lineage leukemia (MLL) gene with CD19 CAR-T cells.
|
26907630 |
2016 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
However, rare cases of mature B-ALL with non-L3 morphology and MLL-AF9 fusion have been reported, and such cases are characterized by a rapid and aggressive clinical course.
|
27084248 |
2016 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Conversely, the genome-wide mutational landscape in MLL-rearranged infant B-ALL has been reported silent.
|
27119507 |
2016 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Poor prognosis BCR-ABL and MLL-AF4 was detected in two-thirds of pediatric B-ALL and is likely to be the reason for the already reported poor survival of childhood ALL in South-East Asia.
|
26266519 |
2015 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The genetic hallmark of most infant B-ALL is chromosomal rearrangements of the mixed-lineage leukemia (MLL) gene.
|
26463423 |
2015 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
To gain insight into the genomic landscape of infant MLL-AF4 pro-B ALL we performed whole genome sequencing of diagnostic leukemic blasts and matched germline samples from three MLL-AF4 pro-B ALL infants.
|
23893660 |
2013 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Therapy-related pro-B cell acute lymphoblastic leukemia: report of two patients with MLL amplification.
|
23238285 |
2012 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We present here a case of phenotypic precursor-B acute lymphoblastic leukemia (ALL), subsequently found to have both MYC and MLL translocations.
|
20829716 |
2011 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
We demonstrate that CRLF2 is overexpressed in approximately 15% of adult and high-risk pediatric B-ALL that lack MLL, TCF3, TEL, and BCR/ABL rearrangements, but not in B-ALL with these rearrangements or other lymphoid malignancies.
|
20018760 |
2010 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recipients of AF4.MLL- or double-transduced LSPCs developed pro-B ALL, B/T biphenotypic acute leukemia, or mixed lineage leukemia.
|
20194896 |
2010 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Up-regulation of miR-196b coincides with reduced DNA methylation at CpG islands in the promoter regions of miR-196b and the entire HOXA cluster in MLL-rearranged cases compared to in cases of non-MLL precursor B-cell acute lymphoblastic leukemia and normal bone marrow (P<0.05), suggesting an epigenetic origin for miR-196b over-expression.
|
20494936 |
2010 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings suggest that MSCs may be in part tumor-related, highlighting an unrecognized role of the BM milieu on the pathogenesis of MLL-AF4(+) B-ALL.
|
19995953 |
2009 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Differential expression of Ikaros isoforms in monozygotic twins with MLL-rearranged precursor-B acute lymphoblastic leukemia.
|
19131787 |
2008 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
MLL/GAS7 fusion in a pediatric case of t(11;17)(q23;p13)-positive precursor B-cell acute lymphoblastic leukemia.
|
16956839 |
2006 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Allogeneic stem cell transplantation improves the outcome of adults with t(1;19)/E2A-PBX1 and t(4;11)/MLL-AF4 positive B-cell acute lymphoblastic leukemia: results of the prospective multicenter LALA-94 study.
|
17039234 |
2006 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our data identify CD10- cytoplasmic immunoglobulin-positive pre-B ALL as a rare (2.2%) but distinct immuno-subtype of adult ALL that is characterized by a high MLL rearrangement rate and a worse outcome.
|
16123216 |
2005 |