Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE Haploidentical peripheral blood stem cell transplantation without irradiation or busulfan after reduced-intensity conditioning for KMT2A(MLL)-rearranged infant B-cell precursor acute lymphoblastic leukemia: Report of two cases. 28332262 2018
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 Biomarker disease BEFREE Amlexanox Downregulates S100A6 to Sensitize <i>KMT2A/AFF1</i>-Positive Acute Lymphoblastic Leukemia to TNFα Treatment. 28646023 2017
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 Biomarker disease BEFREE Mutations in <i>SETD2</i><i>,</i> encoding the histone 3 lysine 36 trimethyltransferase, are enriched in relapsed acute lymphoblastic leukemia and MLL-rearranged acute leukemia. 29018079 2017
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE TGFβ1 synergizes with FLT3 ligand to induce chemoresistant quiescence in acute lymphoblastic leukemia with MLL gene rearrangements. 28917156 2017
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 Biomarker disease BEFREE Azacitidine successfully maintained the second remission in an infant with KMT2A-rearranged acute lymphoblastic leukemia who relapsed after unrelated cord blood transplantation. 28675638 2017
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE Therapy-related B-lymphoblastic leukemia associated with Philadelphia chromosome and MLL rearrangement: Single institution experience and the review of the literature. 26259760 2016
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 Biomarker disease BEFREE Favorable outcome in non-infant children with MLL-AF4-positive acute lymphoblastic leukemia: a report from the Tokyo Children's Cancer Study Group. 26410102 2016
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 Biomarker disease BEFREE Identification of genes transcriptionally responsive to the loss of MLL fusions in MLL-rearranged acute lymphoblastic leukemia. 25793396 2016
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 Biomarker disease BEFREE In non-DS, frequent abnormalities were MLL rearrangements, mainly MLL-AFF1 in acute lymphoblastic leukemia and MLL-MLLT3 in AML. 24991719 2016
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 Biomarker disease CTD_human The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias. 25730765 2015
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 Biomarker disease BEFREE A distinct set of long non-coding RNAs in childhood MLL-rearranged acute lymphoblastic leukemia: biology and epigenetic target. 24488769 2015
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE Therapy-related B lymphoblastic leukemia with t(4;11)(q21;q23)/AF4-MLL in a patient with mantle cell lymphoma after recent aggressive chemotherapy: a unique case report. 24817983 2015
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE Acute lymphoblastic leukemia in infants (< 1 year-of-age) is characterized by a high incidence of MLL rearrangements. 24736461 2015
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 Biomarker disease CTD_human Acute lymphoblastic leukemia in infants (< 1 year-of-age) is characterized by a high incidence of MLL rearrangements. 24736461 2015
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 Biomarker disease BEFREE MLL partner genes in secondary acute lymphoblastic leukemia: report of a new partner PRRC1 and review of the literature. 25205603 2015
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE Bilateral ovarian B-lineage lymphoblastic lymphoma with MLL gene rearrangement: a novel case in infancy. 25493458 2015
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE Early use of allogeneic hematopoietic stem cell transplantation for infants with MLL gene-rearrangement-positive acute lymphoblastic leukemia. 24888273 2015
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE The role of MLL gene deregulation in rare cases of isolated lymphoblastic lymphoma in infants is obscure. 24635731 2015
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 Biomarker disease BEFREE Depletion of JMJD1C impairs expansion and colony formation of human leukemic cell lines, with the strongest effect observed in the MLL-rearranged ALL cell line SEM. 24501218 2014
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 AlteredExpression disease BEFREE In B-cell-precursor acute lymphoblastic leukemia we observed a significant association of a high CD45 expression with older age, high initial white blood cell count, ETV6/RUNX1 negativity, absence of high hyperdiploidy (P<0.0001), MLL/AF4 positivity (P=0.002), BCR/ABL1 positivity (P=0.007), prednisone poor response (P=0.002) and minimal residual disease (P<0.0001). 23911702 2014
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 Biomarker disease BEFREE CDKN1A-mediated responsiveness of MLL-AF4-positive acute lymphoblastic leukemia to Aurora kinase-A inhibitors. 24382688 2014
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE The clinical characteristics, therapy and outcome of 85 adults with acute lymphoblastic leukemia and t(4;11)(q21;q23)/MLL-AFF1 prospectively treated in the UKALLXII/ECOG2993 trial. 23349309 2013
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 Biomarker disease BEFREE MLL-AF4 acute lymphocytic leukemia exhibits both myeloid and B-cell surface markers, suggesting that the transformed cells are B-cell myeloid progenitor cells. 23893300 2013
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 Biomarker disease BEFREE In the group of patients with acute lymphoblastic leukemia and an identified MLL fusion partner, 47% showed the presence of an MLL-AFF1 fusion, as a result of a t(4;11). 22846743 2013
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 GeneticVariation disease BEFREE Prognostic significance of FLT3 mutational status and expression levels in MLL-AF4+ and MLL-germline acute lymphoblastic leukemia. 22705992 2013