MMP1, matrix metallopeptidase 1, 4312

N. diseases: 589; N. variants: 19
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.900 GeneticVariation disease BEFREE Polymorphisms in MMP2 and MMP9 but not in MMP1 and MMP12 are associated with the risk of COPD in the Mexican mestizo population. 26439471 2015
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.900 GeneticVariation disease BEFREE In this report, we performed Meta analysis to investigate the association between four kinds of MMP single nucleotide polymorphisms (SNP, MMP1 -1607 1G/2G, MMP3 -1171 5A/6A, MMP9 -1562 C/T, MMP12 -82 A/G) and COPD risk from 21 studies including 4184 cases and 5716 controls. 24085258 2013
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.900 GeneticVariation disease BEFREE Polymorphisms in MMP1 were not consistently associated with prevalent COPD or incident NSCLC nor with survival in NSCLC. 22993337 2012
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.900 GeneticVariation disease BEFREE Here we review evidence that genetic polymorphisms in matrix metalloproteinase genes MMP1, MMP9 and MMP12 may be important in the development of COPD. 12383023 2002
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.900 GeneticVariation disease BEFREE When stratified by ethnicity, results indicated MMP-1 -1607G/GG (recessive model: G/G vs G/GG+GG/GG; OR: 1.20; 95% CI: 1.01-1.44; p = 0.04) and MMP-9 -1562 C/T (dominant model; OR: 1.66; 95% CI: 1.01-2.71; p = 0.04) were correlated with COPD susceptibility among Caucasians and Asians respectively. 23555986 2013
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.900 GeneticVariation disease BEFREE We also found that the chronic obstructive pulmonary disease (COPD)-predisposing TRPV4P19S variant enhances Ca2+ influx and MMP 1 activation, providing mechanistic linkage between man-made air pollution and human airway disease. 21245013 2011
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.900 GeneticVariation disease BEFREE However, MMP-1 rs1799750 1G > 2G and MMP-3 rs3025058 5A > 6A were not associated with COPD risk (all P > 0.05). 27173221 2016
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.900 GeneticVariation disease BEFREE No significant associations were found between genetic variations in MMP-1 and MMP-2 variants and the risk of development of COPD. 27412345 2016
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.900 GeneticVariation disease BEFREE To investigate the association of 3 polymorphisms of MMP genes (MMP-1 -1607G-->GG, MMP-9 -1562C-->T and MMP-12 N357S), which have been reported to be associated with COPD-related phenotypes, with the risk of COPD in a Korean population. 20160424 2010
CUI: C0079474
Disease: Hallopeau-Siemens Disease
Hallopeau-Siemens Disease 		0.630 GeneticVariation disease BEFREE An investigation into the MMP1 gene promoter region polymorphism--1607 2G with recessive dystrophic epidermolysis bullosa disease severity in northeastern Mexican patients. 24899116 2014
CUI: C0079474
Disease: Hallopeau-Siemens Disease
Hallopeau-Siemens Disease 		0.630 GeneticVariation disease BEFREE Exclusion of stromelysin-1, stromelysin-2, interstitial collagenase and fibronectin genes as the mutant loci in a family with recessive epidermolysis bullosa dystrophica and a form of cerebellar ataxia. 1353052 1992
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.600 GeneticVariation disease BEFREE Synergistic effect of collagenase-1 (MMP1), stromelysin-1 (MMP3) and gelatinase-B (MMP9) gene polymorphisms in breast cancer. 28961241 2017
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.600 GeneticVariation disease BEFREE We found no strong association between MMP1 variation and the risk of MM or breast cancer. 21642878 2011
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.600 GeneticVariation disease BEFREE The contribution of MMP1 promoter 1607 genotype to prognosis and subtypes of breast cancer needs further investigation. 27354592 2016
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.600 GeneticVariation disease BEFREE Our findings suggest that the polymorphic genotypes at MMP1 promoter -1607 investigated in the current study, may not play a major role in determining cancer susceptibility to breast cancer in Taiwan. 29695550 2018
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.600 GeneticVariation disease BEFREE MMP1 [4 single nucleotide polymorphisms (SNPs)] and MMP2 (2 SNPs) were associated with breast cancer overall. 23696797 2013
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.600 GeneticVariation disease BEFREE An association between the matrix metalloproteinase 1 promoter gene polymorphism and lymphnode metastasis in breast cancer. 15149160 2004
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.600 GeneticVariation disease BEFREE Our findings suggest that the polymorphic genotypes at MMP1 promoter -1607 investigated in the current study, may not play a major role in determining cancer susceptibility to breast cancer in Taiwan. 29695550 2018
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.600 GeneticVariation disease BEFREE We found no strong association between MMP1 variation and the risk of MM or breast cancer. 21642878 2011
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.600 GeneticVariation disease BEFREE MMP1 [4 single nucleotide polymorphisms (SNPs)] and MMP2 (2 SNPs) were associated with breast cancer overall. 23696797 2013
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.600 GeneticVariation disease BEFREE The contribution of MMP1 promoter 1607 genotype to prognosis and subtypes of breast cancer needs further investigation. 27354592 2016
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.600 GeneticVariation disease BEFREE An association between the matrix metalloproteinase 1 promoter gene polymorphism and lymphnode metastasis in breast cancer. 15149160 2004
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.600 GeneticVariation disease BEFREE Synergistic effect of collagenase-1 (MMP1), stromelysin-1 (MMP3) and gelatinase-B (MMP9) gene polymorphisms in breast cancer. 28961241 2017
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.600 GeneticVariation group LHGDN An association between the matrix metalloproteinase 1 promoter gene polymorphism and lymphnode metastasis in breast cancer. 15149160 2004
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.600 GeneticVariation group LHGDN Polymorphisms of the promoter regions of matrix metalloproteinases genes MMP-1 and MMP-9 in breast cancer. 16267613 2006