|
AA amyloidosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Recently, a role for MMP-1 has been suggested in the pathogenesis of AA amyloidosis.
|
18815155 |
2008 |
|
Abnormal blistering of the skin
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Abnormality of the anus
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Absent fingernail
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Absent toenail
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Actinic keratosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, MMP-1 expression could be an early event in the development of SCC, and AK demonstrating MMP-1 mRNA, might be in a more advanced dysplastic state, progressing to SCC.
|
10362121 |
1999 |
|
acute aortic dissection
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Pooled analyses demonstrated no significant differences in MMP-1 (4 studies; P = 0.21), MMP-2 (5 studies; P = 0.62) and MMP-3 levels (2 studies; P = 0.94) between AAD patients and control subjects; and significantly higher MMP-8 (2 studies; SMD 2.11; P = 0.020), MMP-9 (9 studies; SMD 1.54; P < 0.001) and MMP-12 levels (2 studies; SMD 1.33; P < 0.001) in AAD patients than in control subjects.
|
31808522 |
2020 |
|
Acute Chest Syndrome
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to examine the association between MMP1-1607dupG (rs1799750) and MMP3-1171dupA (rs3025058) gene polymorphisms and acute coronary syndromes (ACS) in the form of unstable angina.
|
29044936 |
2017 |
|
Acute Chest Syndrome
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggested that genetic variations in the matrix metalloproteinase-1 gene promoter may contribute to interindividual variability in risk of ACS, and help predict susceptible individuals.
|
18480665 |
2008 |
|
Acute Chest Syndrome
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Because of linkage disequilibrium, MMP1 and MMP3 polymorphisms were combined on chromosome 11q22.3, and the 5A-1171-G-519 haplotype had a genetic risk factor for ACS (OR=1.505, 95% CI=1.219-1.857, P=0.00013), whereas the 6A-1171-G-519 haplotype had a decreased risk of ACS (OR=0.815, 95% CI=0.677-0.981, P=0.03).
|
23377317 |
2013 |
|
Acute Coronary Syndrome
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to examine the association between MMP1-1607dupG (rs1799750) and MMP3-1171dupA (rs3025058) gene polymorphisms and acute coronary syndromes (ACS) in the form of unstable angina.
|
29044936 |
2017 |
|
Acute Coronary Syndrome
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Within this context, our aim was to examine whether MMP1, MMP3, and MMP9 gene polymorphisms are associated with susceptibility to acute coronary syndrome (ACS) or angiographic coronary artery disease (CAD).
|
23377317 |
2013 |
|
Acute Coronary Syndrome
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Impact of matrix metalloproteinase-1 gene variations on risk of acute coronary syndrome.
|
18480665 |
2008 |
|
Acute lymphocytic leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
We performed a comprehensive analysis of the impact of IKZF1(del) in a large cohort of children (n=1223) with BCR-ABL1-negative BCP-ALL treated in the EORTC-CLG trial 58951.
|
26050650 |
2015 |
|
Acute myocardial infarction
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
We designed to investigate the association of acute MI (AMI) with a polymorphism in the human MMP-1, 2, 3, and 9 genes in Iranian patients with AMI.
|
20616708 |
2010 |
|
Acute myocardial infarction
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Matrix metalloproteinase-1 promoter polymorphisms and changes in left ventricular volume following acute myocardial infarction.
|
15476622 |
2004 |
|
Acute myocardial infarction
|
0.030 |
Biomarker
|
disease |
BEFREE |
Therefore, we investigated the activities of MMP-1, -2, -3, and -9 which play an important role in AMI.
|
20221893 |
2010 |
|
Acute periodontitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The present study aimed to examine the distribution of MMP-1 genotypes in a group of Chinese subjects with generalized aggressive periodontitis and a group of periodontally healthy subjects, and to evaluate the possible association of the MMP-1 promoter polymorphism with aggressive periodontitis.
|
16302919 |
2005 |
|
Addictive Behavior
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
In this study, results concluded that SNPs in the MMP1 promoter region may be associated with susceptibility to OSMF as well as HNSCC in an Indian population and addiction habits such as areca nut chewing and alcohol abuse may enhance the expression of the 2G allele of MMP1 genes in OSMF and HNSCC cases.
|
20860530 |
2010 |
|
Adenocarcinoma
|
0.060 |
GeneticVariation
|
group |
BEFREE |
No association of the matrix metalloproteinase 1 promoter polymorphism with susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma in northern China.
|
15832405 |
2005 |
|
Adenocarcinoma
|
0.060 |
Biomarker
|
group |
BEFREE |
MMP-1 is a (pre-)invasive factor in Barrett-associated esophageal adenocarcinomas and is associated with positive lymph node status.
|
20946664 |
2010 |
|
Adenocarcinoma
|
0.060 |
AlteredExpression
|
group |
BEFREE |
In keeping with these findings, microarray analysis and immunohistochemistry performed on biopsy samples showed enhanced expression of MMP-1, -3, -7 and -10 and TIMP-1 in the progression from non-dysplastic BO to adenocarcinoma, although this could not be directly attributed to the effect of NO.
|
20584750 |
2010 |
|
Adenocarcinoma
|
0.060 |
Biomarker
|
group |
BEFREE |
This study shows that the ERK-PEA3-MMP-1 axis is upregulated in oesophageal adenocarcinoma cells and is a potentially important driver of the metastatic progression of oesophageal adenocarcinomas.
|
21143918 |
2010 |
|
Adenocarcinoma
|
0.060 |
Biomarker
|
group |
BEFREE |
Expression of the MMP-1 gene in the stromal cells was more common in well differentiated gastric adenocarcinoma than in poorly differentiated adenocarcinomas.
|
7951846 |
1994 |
|
Adenocarcinoma
|
0.060 |
Biomarker
|
group |
BEFREE |
To elucidate the involvement of MMP-1 in human pancreatic ductal adenocarcinoma, we performed immunohistochemical analysis on tissues from 2 fetal pancreases, 5 normal pancreases, 6 cases of chronic pancreatitis, and 46 pancreatic ductal adenocarcinomas.
|
10430270 |
1999 |