MMP1, matrix metallopeptidase 1, 4312

N. diseases: 589; N. variants: 19
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.600 Biomarker group CTD_mouse Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K. 25330770 2014
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.600 Biomarker group CTD_human Matrix metalloproteinase Mmp-1a is dispensable for normal growth and fertility in mice and promotes lung cancer progression by modulating inflammatory responses. 23548910 2013
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.600 Biomarker group BEFREE Promotion of metastasis in response to miR-224 downregulation was associated with derepression of the stroma-associated RKIP target genes, CXCR4, MMP1, and OPN, which are involved in breast tumor metastasis to the bone. 22809510 2012
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.600 AlteredExpression group BEFREE Analysis of matrix metalloproteinase-1 gene polymorphisms and expression in benign and malignant breast tumors. 22011282 2011
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.600 Biomarker group BEFREE Both a MMP-1 inhibitor and P1pal-7 significantly promote apoptosis in breast tumor xenografts and inhibit metastasis to the lungs by up to 88%. 19622769 2009
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.600 AlteredExpression group LHGDN Matrix metalloproteinase localisation by in situ-RT-PCR in archival human breast biopsy material. 17669621 2008
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.600 Biomarker group LHGDN Plasma MMP1 and MMP8 expression in breast cancer: protective role of MMP8 against lymph node metastasis. 18366705 2008
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.600 Biomarker group LHGDN High MMP-1 mRNA expression is a risk factor for disease-free and overall survivals in patients with invasive breast carcinoma. 17663001 2008
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.600 GeneticVariation group LHGDN Polymorphisms of the promoter regions of matrix metalloproteinases genes MMP-1 and MMP-9 in breast cancer. 16267613 2006
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.600 Biomarker group BEFREE MMP-1 (interstitial collagenase) has been associated with MDA-MB-231 invasion in vitro, while MMP-3 (stromelysin-1) has been localised around invasive cells of breast tumours in vivo. 16430785 2006
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.600 Biomarker group BEFREE We conclude that MMP-1 expression is essential for the ability of MDA-231 cells to invade and destroy a collagen matrix and in vivo experiments suggest an important role for MMP-1 in breast tumor growth. 16322260 2005
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.600 Biomarker group LHGDN Modulation of monocyte matrix metalloproteinase-2 by breast adenocarcinoma cells. 16168111 2005
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.600 GeneticVariation group LHGDN An association between the matrix metalloproteinase 1 promoter gene polymorphism and lymphnode metastasis in breast cancer. 15149160 2004
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.600 AlteredExpression group LHGDN The 2G single nucleotide polymorphism (SNP) in the MMP-1 promoter contributes to high levels of MMP-1 transcription in MCF-7/ADR breast cancer cells. 14692651 2003
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.600 AlteredExpression group BEFREE The levels of the matrix metalloproteinase MMP1 mRNA in three breast tumour cell lines with varying numbers of epidermal growth factor (EGF) receptors, MDA-MB-231, T47D and MCF7, were investigated following treatment with EGF or TGF alpha in serum-free medium for up to 24 h. A higher level of MMP1 mRNA was found in both control and treated MDA-MB-231 cells compared with the other two cell lines. 9014756 1996