Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 AlteredExpression disease BEFREE Tissue inhibitor of matrix metalloproteinase-1 expression in colorectal cancer liver metastases is associated with vascular structures. 25594187 2016
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 AlteredExpression disease BEFREE Both UC active and inactive tissue displayed evidence, at both the gene expression and protein level, of a positive precancerous state as indicated by increases in the expression of Chitinase 3-Like-1, and the colorectal cancer metastasis marker MMP1. 26034135 2016
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 GeneticVariation disease BEFREE The association of matrix metalloproteinase-1 genetic polymorphism (-1607 1G>2G) with colorectal cancer: a meta-analysis. 23873107 2014
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 Biomarker disease CTD_human Matrix metalloproteinase Mmp-1a is dispensable for normal growth and fertility in mice and promotes lung cancer progression by modulating inflammatory responses. 23548910 2013
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 Biomarker disease BEFREE Promotion of cell invasion of CRC cell lines exposed to MMP1/2 inhibitors were confirmed in vitro. 21531813 2011
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 AlteredExpression disease BEFREE This finding supports the notion that the combination of inappropriate STAT3 and AP-1 activities drives elevated MMP-1 expression and tissue invasion in colorectal cancer and is of clinical relevance. 21410405 2011
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 GeneticVariation disease BEFREE The aim of this study was to investigate the association of single-nucleotide polymorphism (SNP) at MMP-1 16071G/2G, MMP-7 181A/G, and MMP-9 279R/Q genes with CRC in the southwest Chinese Han population. 20662554 2010
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 GeneticVariation disease BEFREE Subjects with the MMP-1 nt-1607 polymorphism have an increased association with colorectal cancer. 19507256 2009
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 GeneticVariation disease BEFREE The collagenase-1 (MMP-1) gene promoter polymorphism - 1607/2G is associated with favourable prognosis in patients with colorectal cancer. 17311017 2007
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 GeneticVariation disease BEFREE In this study, we assessed the functional effects of these polymorphisms on MMP1 gene promoter activity in cell lines of melanoma (A2058 and A375), breast cancer (MCF7 and MDA-MB-231), lung cancer (A549 and H69), and colorectal cancer (HT-29, SW-620) by comparing the promoter strengths of 10 most common haplotypes deriving from these polymorphisms. 17339606 2007
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 GeneticVariation disease BEFREE Clinical implications of matrix metalloproteinase-1, -3, -7, -9, -12, and plasminogen activator inhibitor-1 gene polymorphisms in colorectal cancer. 17608852 2007
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 GeneticVariation disease BEFREE No association between the polymorphisms in matrix metalloproteinase-1 and matrix metalloproteinase-3 promoter regions and colorectal cancer in Chinese. 16937230 2006
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 GeneticVariation disease BEFREE Prognostic significance of MMP-1 and MMP-3 functional promoter polymorphisms in colorectal cancer. 15701845 2005
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 AlteredExpression disease BEFREE Association of ets-related transcriptional factor E1AF expression with tumour progression and overexpression of MMP-1 and matrilysin in human colorectal cancer. 12898592 2003
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 AlteredExpression disease BEFREE Stromal expression of invasion-promoting, matrix-degrading proteases MMP-1 and -9 and the Ets 1 transcription factor in HNPCC carcinomas and sporadic colorectal cancers. 12949792 2003
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 GeneticVariation disease BEFREE Our present data suggest that the MMP-1 and MMP-3 promoter polymorphisms may be associated with a colorectal cancer susceptibility in Japanese. 12432557 2002
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer
0.400 GeneticVariation disease BEFREE Matrix metalloproteinase-1 promoter polymorphism 1G/2G is correlated with colorectal cancer invasiveness. 11489811 2001