Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here, we examined the relationship between circulating serpina3g, matrix metalloproteinase-9 (MMP-9), and tissue inhibitor of metalloproteinase-1 and -2 (TIMP-1 and -2, respectively) and severity of COPD.
|
30781876 |
2019 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Baseline plasma concentration of anti-elastin antibodies and elastin-degrading enzymes (eg, matrix metalloproteinase-9, and -12, and neutrophil elastase) were measured in the same cohort. elastin fragment-specific CD 4<sup>+</sup> T cell expression of interferon-γ, and anti-elastin antibodies were dependent on history of smoking in TAA / TAD patients but were independent of chronic obstructive pulmonary disease.
|
30957625 |
2019 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
By anchoring MMP-8 and MMP-9 to PMN surfaces, membrane-bound TIMP-1 plays a counterintuitive role in promoting PMN pericellular proteolysis occurring in chronic obstructive pulmonary disease and other diseases.
|
31019060 |
2019 |
Chronic Obstructive Airway Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Additionally, the significant inverse relationships between parameters of lung function (FEV<sub>1</sub>% and FEV<sub>1</sub>/FVC) and proteins level were found in ridge regression models, especially we found that FEV<sub>1</sub>% decreased when MMP-9 level increased in controls and patients with COPD group.
|
30643813 |
2018 |
Chronic Obstructive Airway Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The level of MMP-9 was significantly higher in COPD patients with >3 comorbidities, a COTE index of ≥4 and cardiovascular disease as well as coronary heart disease (t=6.40, 2.53, 3.65 and 2.90, P<0.05).
|
30542429 |
2018 |
Chronic Obstructive Airway Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Additionally, specific activation of phosphoinositide 3‑kinase (PI3K) signaling, using insulin‑like growth factor‑1 (IGF‑1), promoted cell proliferation and cell cycle progression, increased expression of TGFβ1, FGF‑1, PI3K, AKT, phospho‑AKT, serine/threonine‑protein kinase mTOR (mTOR), phospho‑mTOR and TIMP1, promoted cell migration capacity and reduced the expression level of MMP‑9 in cells from COPD rats.
|
30066869 |
2018 |
Chronic Obstructive Airway Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Therefore, this study aimed to evaluate the effect of conjugated linoleic acid (CLA) supplement as natural antioxidants on oxidative stress levels, and MMP2 and MMP9 serum levels in COPD patients.
|
29765212 |
2018 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Serum CyPA positively correlated with serum interleukin-6, matrix metalloproteinase-9 and high-sensitivity C-reactive protein in both the exacerbation and convalescence phases of COPD.
|
29403273 |
2018 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
The levels of innate defense proteins associated with chronic obstructive pulmonary disease, such as elastase and matrix metalloproteinase-9, were significantly elevated in e-cigarette users as well.
|
29053025 |
2018 |
Chronic Obstructive Airway Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
A COPD model was employed by exposing mice to cigarette smoke and the expression levels of MMP-9 and MMP-12 were significantly increased in the lungs.
|
29358724 |
2018 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
In adjusted models within each cohort, elevated MMP-9 was associated with increased odds (odds ratio [OR], 1.71; 95%CI, 1.00-2.90; and OR, 3.03; 95%CI, 1.02-9.01), frequency (incidence rate ratio [IRR], 1.45; 95%CI, 1.23-1.7; and IRR, 1.24; 95%CI, 1.03-1.49), and shorter time-to-first AECOPD (21.7 versus 31.7 months and 14 versus 21 months) in SPIROMICS and COPDGene, respectively.
|
30429371 |
2018 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
However, concentration ratio of MMP-9 released from PMN exposed to 4% CSE or 0% CSE of each participant was significantly higher for healthy subjects than for COPD patients (P = 0.025).
|
29222599 |
2018 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
While the triad discriminated between smokers and non-smokers in the COPD group, MMP-9 and proMMP-9/NGAL (but not NGAL) discriminated between smokers with and without COPD.
|
28004483 |
2017 |
Chronic Obstructive Airway Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Study on the expression of Toll-like receptor 4 and matrix metalloproteinase-9 in patients with chronic obstructive pulmonary disease and their clinical significance.
|
28537664 |
2017 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Effect of Liuweibuqi capsules on the balance between MMP-9 and TIMP1 and viability of alveolar macrophages in COPD.
|
28831024 |
2017 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
To determine whether the circulating levels of inflammatory markers, Tn-C and MMP-9 are associated with LVDD in COPD patients.
|
26663885 |
2017 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
PPARγ and TIMP-1 concentrations were decreased and the concentration of MMP-9 and the ratio of MMP9/TIMP1 were enhanced in the induced sputum of COPD patients, compared to the healthy controls.
|
29268377 |
2017 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Finally, the authors refer to the studies on MMP-9 inhibition as a new perspective for increasing the effectiveness of treatment in asthma and COPD.
|
26123447 |
2016 |
Chronic Obstructive Airway Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our study is the first to reveal an interaction between the MMP9-1562T allele and cigarette smoke in COPD, emphasising gene-environment interactions as a possible cause of lung damage in the pathogenesis of COPD..
|
27270564 |
2016 |
Chronic Obstructive Airway Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Based on our meta-analysis, MMP-9 rs3918242 C > T is correlated with susceptibility to COPD, but MMP-1 rs1799750 1G > 2G and MMP-3 rs3025058 5A > 6A are not.
|
27173221 |
2016 |
Chronic Obstructive Airway Disease
|
0.600 |
Therapeutic
|
disease |
RGD |
Liuweibuqi capsules can improve the symptoms of COPD possibly by regulating the expression of the JAK1/STAT3 pathway and MMP9/TIMP1.
|
25842729 |
2015 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Taken together, our results suggest that MMP-9 serves as a biomarker for the grade and severity of COPD.
|
26291981 |
2015 |
Chronic Obstructive Airway Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Matrix Metalloproteinase-9 (279R/Q) Polymorphism is Associated with Clinical Severity and Airflow Limitation in Tunisian Patients with Chronic Obstructive Pulmonary Disease.
|
26303146 |
2015 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Polymorphisms in MMP2 and MMP9 but not in MMP1 and MMP12 are associated with the risk of COPD in the Mexican mestizo population.
|
26439471 |
2015 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Moreover, inhibiting Src deterred the cigarette smoke-mediated induction of matrix metalloproteinase-9 and -12 in alveolar macrophages and lung expression of cathepsin K, IL-17, TNF-α, MCP-1, and KC, all key factors in the pathogenesis of COPD.
|
24111605 |
2014 |