Pulmonary Emphysema
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Overall, our data strongly suggest that PARP-1 inhibition blunts elastase-induced MMP-2 and MMP-9 expression, which may be partly responsible for prevention of emphysema.
|
30993494 |
2019 |
Pulmonary Emphysema
|
0.400 |
Biomarker
|
disease |
BEFREE |
MMP-9 concentration and the MMP-9/TIMP-1 ratio were higher in patients with emphysema than in other phenotypes (both with <i>p</i> < 0.01).
|
30781876 |
2019 |
Pulmonary Emphysema
|
0.400 |
Biomarker
|
disease |
BEFREE |
A total of 94 patients with COPD were divided into four groups according to the severity of their emphysema; in each patient, comorbidities were recorded and inflammatory biomarkers, including MMP-9 and TIMP-1 were determined in circulating blood.
|
30542429 |
2018 |
Pulmonary Emphysema
|
0.400 |
Biomarker
|
disease |
BEFREE |
Peroxisome proliferator-activated receptor-γ in induced sputum is correlated with MMP-9/TIMP-1 imbalance and formation of emphysema in COPD patients.
|
29268377 |
2017 |
Pulmonary Emphysema
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The T allele in MMP-9 (C-1562T) possibly predisposes patients with pulmonary fibrosis to develop emphysema.
|
28254114 |
2017 |
Pulmonary Emphysema
|
0.400 |
Biomarker
|
disease |
BEFREE |
Protective effect of Galectin-9 in murine model of lung emphysema: Involvement of neutrophil migration and MMP-9 production.
|
28704475 |
2017 |
Pulmonary Emphysema
|
0.400 |
Biomarker
|
disease |
CTD_human |
A comparative study of matrix remodeling in chronic models for COPD; mechanistic insights into the role of TNF-α.
|
25106431 |
2014 |
Pulmonary Emphysema
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our findings strengthen the hypothesis of the importance of protease-antiprotease balance in pathogenesis of emphysema and shed light on the aetiology of different emphysema subtypes by associating MMP9 and TGFB1 to centrilobular emphysema, and TIMP2 and TNF to paraseptal emphysema and/or airflow obstruction.
|
23734748 |
2013 |
Pulmonary Emphysema
|
0.400 |
Biomarker
|
disease |
BEFREE |
Especially MMP9, but also MMP2, MMP7, and MMP12 seem to be involved in human emphysema.
|
24043489 |
2013 |
Pulmonary Emphysema
|
0.400 |
Biomarker
|
disease |
BEFREE |
SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD.
|
24039251 |
2013 |
Pulmonary Emphysema
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We postulate that these developmental epigenetic mechanisms by which Smad3 regulates MMP9 transcription cell autonomously may be important in modulating both emphysema and pulmonary fibrosis and that this could explain why both pathologies can appear within the same lung specimen.
|
23161884 |
2013 |
Pulmonary Emphysema
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Relationship of matrix metalloproteinase mRNA expression and genetic polymorphisms to emphysema.
|
16921111 |
2006 |
Pulmonary Emphysema
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To determine if MMP-9 (C-1562T) is related to the development of COPD in the Japanese population and whether it is associated with development of pulmonary emphysema assessed by high-resolution computed tomographic (HRCT) parameters.
|
16126934 |
2005 |
Pulmonary Emphysema
|
0.400 |
Biomarker
|
disease |
BEFREE |
Similarly, MMP mRNA and protein, primarily MMP-9, localized to the areas of emphysema.
|
15714064 |
2005 |
Pulmonary Emphysema
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Another study found an association between an MMP9 polymorphism and the development of smoking-induced pulmonary emphysema in Japanese smokers.
|
12383023 |
2002 |
Pulmonary Emphysema
|
0.400 |
Biomarker
|
disease |
BEFREE |
MMP1 (interstitial collagenase), MMP9 (gelatinase B) and MMP12 (macrophage elastase) are thought to be important in the development of emphysema.
|
11875051 |
2002 |
Pulmonary Emphysema
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the polymorphism of MMP-9 acts as a genetic factor for the development of smoking-induced pulmonary emphysema.
|
11708786 |
2001 |
Pulmonary Emphysema
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The following study examines the lung parenchyma of 23 patients with emphysema and 8 normal control samples for the expression of matrix matalloproteinase-1 (MMP-1), MMP-12, and MMP-9.
|
11254539 |
2001 |