MMP9, matrix metallopeptidase 9, 4318

N. diseases: 1337; N. variants: 31
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0034067
Disease: Pulmonary Emphysema
Pulmonary Emphysema
0.400 AlteredExpression disease BEFREE Overall, our data strongly suggest that PARP-1 inhibition blunts elastase-induced MMP-2 and MMP-9 expression, which may be partly responsible for prevention of emphysema. 30993494 2019
CUI: C0034067
Disease: Pulmonary Emphysema
Pulmonary Emphysema
0.400 Biomarker disease BEFREE MMP-9 concentration and the MMP-9/TIMP-1 ratio were higher in patients with emphysema than in other phenotypes (both with <i>p</i> < 0.01). 30781876 2019
CUI: C0034067
Disease: Pulmonary Emphysema
Pulmonary Emphysema
0.400 Biomarker disease BEFREE A total of 94 patients with COPD were divided into four groups according to the severity of their emphysema; in each patient, comorbidities were recorded and inflammatory biomarkers, including MMP-9 and TIMP-1 were determined in circulating blood. 30542429 2018
CUI: C0034067
Disease: Pulmonary Emphysema
Pulmonary Emphysema
0.400 Biomarker disease BEFREE Peroxisome proliferator-activated receptor-γ in induced sputum is correlated with MMP-9/TIMP-1 imbalance and formation of emphysema in COPD patients. 29268377 2017
CUI: C0034067
Disease: Pulmonary Emphysema
Pulmonary Emphysema
0.400 GeneticVariation disease BEFREE The T allele in MMP-9 (C-1562T) possibly predisposes patients with pulmonary fibrosis to develop emphysema. 28254114 2017
CUI: C0034067
Disease: Pulmonary Emphysema
Pulmonary Emphysema
0.400 Biomarker disease BEFREE Protective effect of Galectin-9 in murine model of lung emphysema: Involvement of neutrophil migration and MMP-9 production. 28704475 2017
CUI: C0034067
Disease: Pulmonary Emphysema
Pulmonary Emphysema
0.400 Biomarker disease CTD_human A comparative study of matrix remodeling in chronic models for COPD; mechanistic insights into the role of TNF-α. 25106431 2014
CUI: C0034067
Disease: Pulmonary Emphysema
Pulmonary Emphysema
0.400 Biomarker disease BEFREE Our findings strengthen the hypothesis of the importance of protease-antiprotease balance in pathogenesis of emphysema and shed light on the aetiology of different emphysema subtypes by associating MMP9 and TGFB1 to centrilobular emphysema, and TIMP2 and TNF to paraseptal emphysema and/or airflow obstruction. 23734748 2013
CUI: C0034067
Disease: Pulmonary Emphysema
Pulmonary Emphysema
0.400 Biomarker disease BEFREE Especially MMP9, but also MMP2, MMP7, and MMP12 seem to be involved in human emphysema. 24043489 2013
CUI: C0034067
Disease: Pulmonary Emphysema
Pulmonary Emphysema
0.400 Biomarker disease BEFREE SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD. 24039251 2013
CUI: C0034067
Disease: Pulmonary Emphysema
Pulmonary Emphysema
0.400 AlteredExpression disease BEFREE We postulate that these developmental epigenetic mechanisms by which Smad3 regulates MMP9 transcription cell autonomously may be important in modulating both emphysema and pulmonary fibrosis and that this could explain why both pathologies can appear within the same lung specimen. 23161884 2013
CUI: C0034067
Disease: Pulmonary Emphysema
Pulmonary Emphysema
0.400 GeneticVariation disease LHGDN Relationship of matrix metalloproteinase mRNA expression and genetic polymorphisms to emphysema. 16921111 2006
CUI: C0034067
Disease: Pulmonary Emphysema
Pulmonary Emphysema
0.400 GeneticVariation disease BEFREE To determine if MMP-9 (C-1562T) is related to the development of COPD in the Japanese population and whether it is associated with development of pulmonary emphysema assessed by high-resolution computed tomographic (HRCT) parameters. 16126934 2005
CUI: C0034067
Disease: Pulmonary Emphysema
Pulmonary Emphysema
0.400 Biomarker disease BEFREE Similarly, MMP mRNA and protein, primarily MMP-9, localized to the areas of emphysema. 15714064 2005
CUI: C0034067
Disease: Pulmonary Emphysema
Pulmonary Emphysema
0.400 GeneticVariation disease BEFREE Another study found an association between an MMP9 polymorphism and the development of smoking-induced pulmonary emphysema in Japanese smokers. 12383023 2002
CUI: C0034067
Disease: Pulmonary Emphysema
Pulmonary Emphysema
0.400 Biomarker disease BEFREE MMP1 (interstitial collagenase), MMP9 (gelatinase B) and MMP12 (macrophage elastase) are thought to be important in the development of emphysema. 11875051 2002
CUI: C0034067
Disease: Pulmonary Emphysema
Pulmonary Emphysema
0.400 GeneticVariation disease BEFREE These results suggest that the polymorphism of MMP-9 acts as a genetic factor for the development of smoking-induced pulmonary emphysema. 11708786 2001
CUI: C0034067
Disease: Pulmonary Emphysema
Pulmonary Emphysema
0.400 AlteredExpression disease BEFREE The following study examines the lung parenchyma of 23 patients with emphysema and 8 normal control samples for the expression of matrix matalloproteinase-1 (MMP-1), MMP-12, and MMP-9. 11254539 2001