MMP9, matrix metallopeptidase 9, 4318

N. diseases: 1337; N. variants: 31
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.600 AlteredExpression disease BEFREE Furthermore, there is a strong correlation between the severity of pulmonary fibrosis and serum MMP-9 levels. 30666825 2019
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.600 Biomarker disease BEFREE Macrophage-secreted TSLP and MMP9 promote bleomycin-induced pulmonary fibrosis. 30653976 2019
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.600 AlteredExpression disease BEFREE Therefore, IL-33 may take part in the process of pulmonary fibrosis by regulating expressions of MMP-9 and TIMP-1. 29417309 2018
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.600 Biomarker disease BEFREE Studies revealed that these natural products have several mechanisms of action to ameliorate pulmonary fibrosis such as inhibitory effects against the elevation of inflammatory markers such as NF-κB and preventing an increase in fibrotic markers like MMP-9 and HYP. 30257362 2018
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.600 AlteredExpression disease BEFREE In vivo, intratracheal treatment with Lv-miR-29c significantly increased expression of miR-29c, and reduced expression of β-catenin, matrix metalloproteinase (MMP)-2, and MMP-9 in the lung and levels of transforming growth factor-beta 1 (TGF-β1) and interleukin-6 (IL-6) in bronchoalveolar lavage fluid, and notably attenuated pulmonary fibrosis as evidenced by hydroxyproline content in silica-administered mice. 29216763 2018
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.600 GeneticVariation disease BEFREE The T allele in MMP-9 (C-1562T) possibly predisposes patients with pulmonary fibrosis to develop emphysema. 28254114 2017
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.600 AlteredExpression disease BEFREE Intranasal administration of curcumin significantly inhibited airway inflammation and pulmonary fibrosis, where MMP-9 activities were decreased along with α-smooth muscle actin (α-SMA), MMP-9, TIMP-1, and eotaxin expressions. 27866296 2017
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.600 Therapeutic disease RGD Inhibitory effects of alkaline extract of Citrus reticulata on pulmonary fibrosis. 23318412 2013
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.600 AlteredExpression disease BEFREE We postulate that these developmental epigenetic mechanisms by which Smad3 regulates MMP9 transcription cell autonomously may be important in modulating both emphysema and pulmonary fibrosis and that this could explain why both pathologies can appear within the same lung specimen. 23161884 2013
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.600 Biomarker disease CTD_human In this study, we examined the sequential expression of MMP-2, MMP-9 and TIMP-1 in a rat model of pulmonary fibrosis induced by PQ. 21468558 2011
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.600 GeneticVariation disease BEFREE There was no association of MMP-9(-1562T) and MMP-12(Asn357Ser) polymorphisms with lung fibrosis. 20392358 2010
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.600 AlteredExpression disease BEFREE We studied the effect of MMP9 overexpression in bleomycin-driven lung fibrosis using transgenic mice expressing human MMP9 in alveolar macrophages (hMMP9-TG). 17702637 2007
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.600 Biomarker disease RGD The sources and effects of MMP-2 and MMP-9 differ in BLM-induced rat pulmonary fibrosis. 17121240 2006