Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023418
Disease: leukemia
leukemia
0.080 Biomarker disease BEFREE Finally, AMM2, an inhibitor of c-MPL, was shown to significantly enhance the survival of AE9a leukemia mice when combined with chemotherapeutic agent. 30106501 2018
CUI: C0023418
Disease: leukemia
leukemia
0.080 Biomarker disease BEFREE Hence, we developed a novel strategy that combines both essential signals in 1 transgene by expressing the nonlymphoid hematopoietic growth factor receptor c-MPL (myeloproliferative leukemia), the receptor for thrombopoietin (TPO), in T cells. c-MPL signaling activates pathways shared with conventional costimulatory and cytokine receptor signaling. 29079582 2017
CUI: C0023418
Disease: leukemia
leukemia
0.080 AlteredExpression disease BEFREE Hence, this study provides evidence that up-regulation of wild-type MPL levels promotes leukemia development and maintenance through activation of the PI3K/AKT axis, and suggests that inhibitors of this axis could be effective for treatment of MPL-positive AML. 22613795 2012
CUI: C0023418
Disease: leukemia
leukemia
0.080 GeneticVariation disease BEFREE Mutations in the thrombopoietin receptor gene (myeloproliferative leukemia, MPL) have been reported in patients with JAK2 V617F-negative chronic myeloproliferative disorders (MPDs). 21326037 2011
CUI: C0023418
Disease: leukemia
leukemia
0.080 GeneticVariation disease BEFREE We conclude that MPL(W515L) occurs in a considerable proportion of acute megakaryoblastic leukaemias with myelofibrosis unrelated to PMF. 19194467 2009
CUI: C0023418
Disease: leukemia
leukemia
0.080 AlteredExpression disease LHGDN Modulation of human c-mpl gene expression by thrombopoietin through protein kinase C. 14995067 2003
CUI: C0023418
Disease: leukemia
leukemia
0.080 AlteredExpression disease BEFREE All FAB M6 and M7 and trilineal leukaemias expressed mRNAs for alpha-globin, glycoprotein IIb (GpIIb), erythropoietin receptor (Epo-R) and thrombopoietin receptor (c-mpl), but not for myeloperoxidase (MPO) which in contrast was expressed in the other FAB-subtype leukaemias. 9753066 1998
CUI: C0023418
Disease: leukemia
leukemia
0.080 AlteredExpression disease BEFREE Expression of thrombopoietin and thrombopoietin receptor MPL in human leukemia-lymphoma and solid tumor cell lines. 8960108 1996