Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In the father group, MTHFR C677T was a risk factor for NTDs.
|
31238314 |
2019 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Here, we report on 3 men with hyperhomocysteinemia and the MTHFR C677T homozygous TT genotype that have reproductive histories of fetal NTDs.
|
30633186 |
2019 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
MTHFR C677T, but not A1298C, was associated with neural tube defects (OR, 1.24; 95% CI, 1.08-1.42) and Down syndrome (OR, 1.65; 95% CI, 1.39-1.95).
|
30474229 |
2019 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
For MTHFR rs1801133 polymorphism, mothers having TT and CT genotypes were more likely to affect NTDs in the offspring (OR = 4.105, 95%CI: 1.271-13.258; OR = 3.333, 95%CI: 1.068-10.400).
|
30867013 |
2019 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Low maternal folate concentrations and maternal MTHFR C677T polymorphism are associated with an increased risk for neural tube defects in offspring: a case-control study among Pakistani case and control mothers.
|
29222906 |
2019 |
Neural Tube Defects
|
0.400 |
Biomarker
|
group |
BEFREE |
This study aims to evaluate the association between genetic defects in folate metabolism pathway genes, mainly: Folate hydrolase 1 (FOLH1), Dihydrofolate reductase (DHFR) and Methylenetetrahydrofolate reductase (MTHFR) and neural tube defects from eastern India.
|
30120883 |
2018 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In view of the increased susceptibility of women with the TT genotype of MTHFR to give birth to infants with neural tube defects as well as the effectiveness of formate supplementation in decreasing the incidence of folate-resistant neural tube defects in susceptible mice, it will be important to understand how this genotype decreases the serum formate concentration.
|
29566195 |
2018 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our results suggest that rs2236225 of MTHFD1 gene, rs1801133 of MTHFR gene and rs1801394 of MTRR gene were associated with NTDs in Han population of Northern China.
|
29392422 |
2018 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The methylenetetrahydrofolate reductase (MTHFR) polymorphism is a risk factor for neural tube defects.
|
27173682 |
2016 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In this study, the genotype distribution of the MTHFR gene A1298C polymorphism and the levels of serum homocysteine, vitamin B12, and folate were evaluated in 33 children with NTDs, their mothers, and 46 healthy controls.
|
27323133 |
2016 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In conclusion, present meta-analysis supports that the maternal MTHFR C677T and MTRR A66G are polymorphisms contributory to risk for NTD.
|
25005003 |
2015 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Variants in MTHFR gene and neural tube defects susceptibility in China.
|
25855017 |
2015 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The interaction of COMT rs737865 and MTHFR C677T was associated with an increased risk of NTDs, especially anencephaly, in a Chinese population with a high prevalence of NTDs.
|
24990354 |
2015 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The association of the C677T polymorphism in the MTHFR gene and NTD susceptibility has been widely demonstrated, but the results are inconclusive.
|
25808073 |
2015 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism is a risk factor for neural tube defects.
|
25788000 |
2015 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Preliminary evidence has suggested that there may be a much greater need for women with the MTHFR 677TT genotype to adhere to the specific recommendation of commencing folic acid prior to conception for the prevention of NTD, but this requires further investigation.
|
24131523 |
2014 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
C677T mutation in methylenetetrahydrofolate reductase gene and neural tube defects: should Japanese women undergo gene screening before pregnancy?
|
24588777 |
2014 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The increased incidence of NTDs in mothers homozygous for the MTHFR 677TT polymorphism and at risk of abnormal carbohydrate metabolism stresses the need for careful metabolic screening in pregnant women, and, if necessary, determination of the MTHFR 677CT genotype in those mothers at risk of developing abnormal carbohydrate metabolism.
|
24737468 |
2014 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our meta-analysis strongly suggested a significant association of the variant MTHFR C677T and a suggestive association of RFC-1 A80G with increased risk of NTDs.
|
23593147 |
2013 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A common C677T polymorphism in MTHFR has been associated with an increased risk for the development of cardiovascular disease, Alzheimer's disease, and depression in adults, and of neural tube defects in the fetus.
|
23116396 |
2013 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Interaction between maternal 5,10-methylenetetrahydrofolate reductase C677T and methionine synthase A2756G gene variants to increase the risk of fetal neural tube defects in a Shanxi Han population.
|
23489792 |
2013 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Haplotype tagging SNPs in the NOS genes were tested for genetic association with NTD subtypes, both for main effects as well as for the presence of interactions with the MTHFR C677T polymorphism.
|
24323870 |
2013 |
Neural Tube Defects
|
0.400 |
Biomarker
|
group |
BEFREE |
Only the association between MTHFR and NTD-risk remained significant after multiple testing correction.
|
24223810 |
2013 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Gene variants in the folate metabolic pathway (e.g., MTHFR rs1801133 (677 C > T) and MTHFD1 rs2236225 (rs2236225" genes_norm="1788;4522">R653Q)) have been found to increase NTD risk.
|
22856873 |
2012 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
For mothers in the lowest folate-intake group, risk of NTDs in offspring was significantly decreased for maternal MTHFR SNPs rs1476413, rs1801131, and rs1801133 (odds ratio [OR] = 0.55, 80% confidence interval [CI]: 0.20, 1.48; OR = 0.58, 80% CI: 0.24, 1.43; OR = 0.69, 80% CI: 0.41, 1.17, respectively), and TYMS SNPs rs502396 and rs699517 (OR = 0.91, 80% CI: 0.53, 1.56; OR = 0.70, 80% CI: 0.38, 1.29).
|
22903727 |
2012 |