|
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
BEFREE |
Genetic polymorphisms of 4 genes, methylenetetrahydrofolate reductase (MTHFR) and apolipoprotein E (ApoE) have been demonstrated to associate with the increased risk for both MDD and stroke, while the association between identified polymorphisms in angiotensin converting enzyme (ACE) and serum paraoxonase (PON1) with depression is still under debate, for the existing studies are insufficient in sample size.
|
30898617 |
2019 |
|
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
This common folate polymorphism is linked with several adverse health outcomes, including stroke, however, recent evidence has identified its novel interaction with riboflavin (the MTHFR cofactor) in relation to blood pressure and risk of developing hypertension.
|
31155015 |
2019 |
|
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Heterozygous and homozygous subjects to the rs1801133 variant of the MTHFR gene had a 3-fold higher risk of stroke.
|
29398535 |
2018 |
|
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Our findings suggested no association between MTHFR gene polymorphisms and susceptibility to hemorrhagic strokes in Moroccan patients.
|
29555401 |
2018 |
|
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
We aimed to investigate the association of Hcy concentration with intracranial atherosclerosis (ICAS) and extracranial AS (ECAS) in hypertensive patients without stroke in Chinese population and to explore modified effect of methylenetetrahydrofolate reductase (MTHFR) C677T on their relationship.
|
29330520 |
2018 |
|
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Among hypertensive patients, we aimed to test the hypothesis that the association between homocysteine and stroke can be modified by the methylenetetrahydrofolate reductase C677T polymorphism and folic acid intervention.
|
28360116 |
2017 |
|
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
To date, limited prospective studies have examined the joint effects of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, hyperhomocysteinemia and conventional vascular risk factors on risk of stroke and stroke death.
|
27126505 |
2017 |
|
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
The combined effects of the MTHFR 3'-UTR polymorphisms and tHcy/folate levels may contribute to stroke prevalence.
|
28963520 |
2017 |
|
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
BEFREE |
The second objective was to determine how a genetic deficiency in methylenetetrahydrofolate reductase (MTHFR), an enzyme involved in folate metabolism, increases vulnerability to stroke.
|
28396257 |
2017 |
|
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
We tested MTHFR C677T for association with stroke subtypes and white matter hyperintensities volume.
|
26839351 |
2016 |
|
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
The frequently assessed hereditary thrombophilia mutations associated with stroke are methylenetetrahydrofolate reductase (MTHFR) c.677C>T, Factor V (F5) c.1691G>A (Leiden), and prothrombin (F2) c.20210G>A.
|
26522268 |
2016 |
|
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Genetic variations in the MTHFR gene seem to contribute to a decreased activity of MTHFR, ultimately confer increased susceptibility to stroke.
|
25107455 |
2015 |
|
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
We aimed to evaluate the effect of methylenetetrahydrofolate reductase (MTHFR) gene 677 C → T polymorphism, which was associated with a higher stroke risk and was common in the Chinese population, as well as homocysteine and estimated glomerular filtration rate (eGFR) levels on the risk of new-onset diabetes (NOD).
|
25700330 |
2015 |
|
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
We found out that mutation of the MTHFR gene in isolation or in combination with other gene mutations is the most important risk factor for stroke in the young.
|
25238925 |
2015 |
|
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
The MTHFR genotype (TT vs. CC/CT) was not associated with hypertension [OR (95% CI) 1.09 (0.95-1.25)], dyslipidemia [OR (95% CI) 0.97 (0.84-1.11)], stroke [HR (95% CI) 0.92 (0.69-1.23)], and all-cause mortality [HR (95% CI) 0.94 (0.77-1.14)], either overall, or in participants with low serum folate or B12 status (P values for interactions 0.15-0.94).
|
24458267 |
2014 |
|
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
The combined results of overall analysis showed that there was significant association between MTHFR gene A1298C polymorphism and adult stroke (allelic model: OR=1.36, 95% CI=1.11-1.67; additive model: OR=1.88, 95% CI=1.12-3.18; dominant model: OR=1.33, 95% CI=1.08-1.65 and recessive model: OR=1.77, 95% CI=1.07-2.94, respectively).
|
25472665 |
2014 |
|
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
For stroke subtypes, the sentinel SNP located upstream of MUT was significantly associated with small-vessel disease (P=0.0022), whereas 1 SNP located in MTHFR was significantly associated with large-vessel disease (P=0.00019).
|
24846872 |
2014 |
|
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
We evaluated the relationship between hyperhomocysteinemia and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and small-vessel disease (SVD) and atherosclerotic large-vessel disease (LVD) in stroke patients.
|
25031284 |
2014 |
|
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
The meta-analysis suggests that the MTHFR C667T genetic polymorphism was associated with increased risk of hemorrhagic stroke, and the T allele may be an important risk factor for hemorrhagic stroke.
|
23428159 |
2013 |
|
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
An interactive effect between the MTHFR 677TT and F2 20210GA polymorphisms showed an increased risk of stroke.
|
24132798 |
2013 |
|
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Ten studies described MTHFR C677T (108 with TT genotype and 2018 with CC genotype) -homocysteine relationship and six studies (735 stroke cases and 713 controls) described homocysteine-ischemic stroke relationship.
|
23505425 |
2013 |
|
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
BEFREE |
Studies from the different ethnic regions of world have reported variable results on association of Apolioprotein E (APOE), Methylenetetrahydrofolate reductase (MTHFR), Endothelial Nitric Oxide Synthase (ENOS), Factor V Leiden (F5), Cytochrome P450 4F2 (CYP4F2), beta-fibrinogen and Phosphodiesterase 4D (PDE4D) gene in stroke.
|
24090469 |
2013 |
|
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Association of the methylenetetrahydrofolate reductase gene A1298C polymorphism with stroke risk based on a meta-analysis.
|
24391036 |
2013 |
|
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Thus, meta-analyses of available data suggest an obvious association between MTHFR C677T polymorphism and hemorrhagic stroke risk, and TT genotype contributes to increased risk of hemorrhagic stroke.
|
23184002 |
2013 |
|
Cerebrovascular accident
|
0.500 |
GeneticVariation
|
group |
BEFREE |
The variant methylenetetrahydrofolate reductase (MTHFR) C677T is associated with elevated homocysteine levels, cardiovascular disease and stroke, which supports a causal relationship between hyperhomocysteinemia and vascular disease.
|
23285280 |
2012 |