MTHFR, methylenetetrahydrofolate reductase, 4524

N. diseases: 985; N. variants: 137
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 GeneticVariation disease BEFREE 5-HTTLPR and <i>MTHFR 677C</i>>T polymorphisms and response to yoga-based lifestyle intervention in major depressive disorder: A randomized active-controlled trial. 30581206 2020
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 GeneticVariation disease BEFREE It has been found that the methylenetetrahydrofolate reductase (MTHFR) gene is associated with major depressive disorder, and the aim of the current study was to examine the possible association between perceived stress and MTHFR methylation, taking into account depressive symptoms as a covariate. 29595559 2018
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 GeneticVariation disease BEFREE Methylenetetrahydrofolate Reductase A1298C Polymorphism and Major Depressive Disorder. 29209581 2017
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 AlteredExpression disease BEFREE MTHFR: Genetic variants, expression analysis and COMT interaction in major depressive disorder. 26021967 2015
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker disease PSYGENET Methylenetetrahydrofolate reductase (MTHFR) genetic variation and major depressive disorder prognosis: A five-year prospective cohort study of primary care attendees. 24123968 2014
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 GeneticVariation disease BEFREE Association analysis of COMT/MTHFR polymorphisms and major depressive disorder in Chinese Han population. 24751310 2014
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker disease PSYGENET Significance of dietary folate intake, homocysteine levels and MTHFR 677 C>T genotyping in South African patients diagnosed with depression: test development for clinical application. 24532086 2014
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker disease PSYGENET Association analysis of COMT/MTHFR polymorphisms and major depressive disorder in Chinese Han population. 24751310 2014
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 GeneticVariation disease BEFREE Methylenetetrahydrofolate reductase (MTHFR) genetic variation and major depressive disorder prognosis: A five-year prospective cohort study of primary care attendees. 24123968 2014
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker disease PSYGENET Interaction between the MTHFR C677T polymorphism and traumatic childhood events predicts depression. 23900311 2013
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker disease PSYGENET We found no significant association of either the BDNF G196A or MTHFR C677T polymorphisms with major depressive disorder neither in female nor male group of patients. 23255668 2012
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 GeneticVariation disease BEFREE We found no significant association of either the BDNF G196A or MTHFR C677T polymorphisms with major depressive disorder neither in female nor male group of patients. 23255668 2012
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 GeneticVariation disease BEFREE No association with the 5,10-methylenetetrahydrofolate reductase gene and major depressive disorder: results of the depression case control (DeCC) study and a meta-analysis. 18165972 2008
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 GeneticVariation disease BEFREE The authors performed a meta-analysis of studies examining the association between polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, including MTHFR C677T and A1298C, and common psychiatric disorders, including unipolar depression, anxiety disorders, bipolar disorder, and schizophrenia. 17074966 2007
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker disease CTD_human The authors performed a meta-analysis of studies examining the association between polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, including MTHFR C677T and A1298C, and common psychiatric disorders, including unipolar depression, anxiety disorders, bipolar disorder, and schizophrenia. 17074966 2007
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 GeneticVariation disease BEFREE Homocysteine levels, MTHFR C677T genotype, and MRI Hyperintensities in late-onset major depressive disorder. 16223965 2005
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 GeneticVariation disease BEFREE Since a common variant of the MTHFR gene, T677(Ala), responsible for the thermolabile MTHFR with less than 50% specific MTHFR activity, has been reported, we examined whether the T677 allele is associated with psychiatric disorders in an unrelated Japanese population consisting of 297 schizophrenics, 32 patients with major depression, 40 patients with bipolar disorder, and 419 controls. 9342205 1997