Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.600 AlteredExpression group BEFREE We show that MYC overexpression (MYC<sup>Tg</sup>) synergizes with KRAS<sup>G12D</sup> to induce an aggressive liver tumor leading to metastasis formation and reduced mouse survival compared with KRAS<sup>G12D</sup> alone. 30643286 2019
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.600 AlteredExpression group BEFREE MiR-198 inhibited cancer by suppressing the expression of MYC in liver neoplasm. 30378283 2018
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.600 Biomarker group BEFREE To determine if genetic loss of SRC-2 is sufficient to accelerate MYC-mediated liver tumorigenesis, we bred Src-2-/- mice with a MYC-induced liver tumor model and observed a significant increase in liver tumor burden. 28273073 2017
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.600 Biomarker group BEFREE C57BL/6 mice received hydrodynamic tail-vein injections of transposons encoding HRAS<sup>G12V</sup> and a short hairpin RNA (shRNA) to down-regulate p53, or those encoding HRAS<sup>G12V</sup> and MYC, or those encoding HRAS<sup>G12V</sup> and TAZ<sup>S89A</sup>, to induce liver tumor formation; mice were also given injections of transposons encoding SMAD7 or shRNA against SMAD2, SMAD3, SMAD4, or SNAI1 (Snail), with or without ectopic expression of Snail. 28734833 2017
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.600 Biomarker group BEFREE Finally, MYC-driven liver tumors exhibit increased sensitivity to acute oxidative stress. 28219903 2017
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.600 AlteredExpression group BEFREE Overexpression of IGF2 accelerates formation of liver tumors in mice with hepatic expression of MYC and AKT1, via activation of IGF1 receptor signaling. 27614046 2016
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.600 Biomarker group BEFREE Identification of MYC-Dependent Transcriptional Programs in Oncogene-Addicted Liver Tumors. 27197165 2016
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.600 Biomarker group BEFREE Our results establish CDK9 inhibition as a therapeutic strategy for MYC-overexpressing liver tumors and highlight the relevance of transcription elongation in the addiction of cancer cells to MYC. 25128497 2014
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.600 Biomarker group BEFREE Finally, we found that a small Myc target gene set of 16 genes could be used to identify liver tumors due to Myc upregulation. 23038063 2013
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.600 Biomarker group BEFREE Increased glutamine catabolism in MYC-induced liver tumors is associated with decreased levels of glutamine synthetase (Glul) and the switch from Gls2 to Gls1 glutaminase. 22326218 2012
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.600 Biomarker group RGD Mechanistic study on liver tumor promoting effects of flutamide in rats. 22076107 2012
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.600 AlteredExpression group BEFREE Our results suggest that continued upregulation of c-Myc target genes promotes the liver tumor formation after about 1 year of age. 22182413 2012
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.600 AlteredExpression group BEFREE Treatment of the human hepatoma cell line HepG2 with hepatic growth factor (Hgf) caused c-Myc protein induction and transcriptional up-regulation of candidate genes, albeit at different levels when individual genes were compared. 22653869 2012
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.600 Therapeutic group RGD Antioxidant N-acetyl-L-cysteine (NAC) supplementation reduces reactive oxygen species (ROS)-mediated hepatocellular tumor promotion of indole-3-carbinol (I3C) in rats. 22129741 2011
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.600 AlteredExpression group BEFREE We found that RB inactivation has minimal effects on the cell cycle, cell death, and differentiation features of liver tumors driven by increased levels of c-MYC. 21573126 2011
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.600 Biomarker group BEFREE The molecular profile of the HCV-associated HCC confirmed central roles for MYC and TGFbeta1 in liver tumor development. 20380719 2010
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.600 AlteredExpression group LHGDN E2F1 inhibits c-Myc-driven apoptosis via PIK3CA/Akt/mTOR and COX-2 in a mouse model of human liver cancer. 18722373 2008
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.600 Biomarker group LHGDN Hepatic stem-like phenotype and interplay of Wnt/beta-catenin and Myc signaling in aggressive childhood liver cancer. 19061838 2008
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.600 AlteredExpression group BEFREE Consistent with the recently reported association between c-MYC overexpression and induction of telomerase activity, we find here that GA treatment of a human hepatoma cell line SMMC-7721 significantly reduced the expression of c-MYC in a time- and concentration-dependent manner accompanied with the down-regulation of the hTERT transcription and the ultimate reduction in telomerase activity. 16257012 2006
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.600 Biomarker group CTD_human Hence, chloroform prevented the hypomethylation and increased mRNA expression of the c-myc gene and the promotion of liver tumors by DCA, while enhancing DCA-promotion of kidney tumors. 11532874 2001
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.600 Biomarker group CTD_human Transgenic mouse models in carcinogenesis: interaction of c-myc with transforming growth factor alpha and hepatocyte growth factor in hepatocarcinogenesis. 8807143 1996
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.600 AlteredExpression group BEFREE The expression of the c-myc gene has previously been shown to be elevated and deregulated in the human hepatoma cell line Hep G2 (B. E. Huber and S. S. Thorgeirsson, Cancer Res., 47: 3414-3420, 1987). 2154325 1990
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.600 AlteredExpression group BEFREE Expression of c-myc gene in human hepatoma. 2415125 1985
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.600 Biomarker group MGD